Desmin Monoclonal Antibody (D33) | Invitrogen MA5-13259 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Desmin Monoclonal Antibody (D33)

catalog :

MA5-13259

quantity :

500 µL

price :

US 431

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

D33

reactivity :

Chinese hamsters, human, mouse, rat, dogs, chicken, bovine, cat, domestic sheep, domestic rabbit, rhesus macaque

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 78

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:50; loading ...	Li H, Shen P, Liang Y, Zhang F. Fibroblastic reticular cell tumor of the breast: A case report and review of the literature. Exp Ther Med. 2016;11:561-564 pubmed
immunohistochemistry; human; 1:50	Tasli F, Vardar E, Argon A, Kabat T, Deniz S, Nart A, et al. Histochemical and immunohistochemical characteristics of elastofibromas. Pol J Pathol. 2014;65:120-4 pubmed
immunocytochemistry; human	Yuan S, Guo Y, Zhou X, Shen W, Chen H. PDGFR-? (+) perivascular cells from infantile hemangioma display the features of mesenchymal stem cells and show stronger adipogenic potential in vitro and in vivo. Int J Clin Exp Pathol. 2014;7:2861-70 pubmed
immunohistochemistry; human	Altinay S, Kusaslan R. Gastrointestinal autonomic nerve tumour of jejunum presenting as a perforated mass. J Pak Med Assoc. 2014;64:461-4 pubmed
immunohistochemistry; human	Yoshioka N, Gros E, Li H, Kumar S, Deacon D, Maron C, et al. Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013;13:246-54 pubmed publisher
immunohistochemistry; human; 1:40	Kara T, Serinsoz E, Arpaci R, Gubur O, Orekici G, Ata A, et al. Contribution of DOG1 expression to the diagnosis of gastrointestinal stromal tumors. Pathol Res Pract. 2013;209:413-7 pubmed publisher
immunohistochemistry; dogs; 1:100	Kimura M, Suzuki K, Fujii Y, Yamamoto R, Shibutani M, Mitsumori K. Gingival rhabdomyosarcoma accompanied by an immature myogenic population immunoreactive for ?-smooth muscle actin in a dog. J Comp Pathol. 2013;149:48-52 pubmed publisher
immunocytochemistry; human	Hasegawa K, Yasuda S, Teo J, Nguyen C, McMillan M, Hsieh C, et al. Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med. 2012;1:18-28 pubmed publisher
immunohistochemistry; human	Zhou Z, Yu M, Yang S, Zhou J, Sun R, Yang G. Dural angioleiomyoma of the middle cranial fossa: a case report and review of the literature. Brain Tumor Pathol. 2013;30:117-21 pubmed publisher
immunohistochemistry; human; 1:50	Wang H, Li K, Wang J. Sclerosing angiomatoid nodular transformation of the spleen: report of five cases and review of literature. Chin Med J (Engl). 2012;125:2386-9 pubmed
immunohistochemistry; cat; 1:10	Yamamoto R, Suzuki K, Uchida K, Onda N, Shibutani M, Mitsumori K. Pancreatic carcinosarcoma in a cat. J Comp Pathol. 2012;147:223-6 pubmed publisher
immunohistochemistry; human; 1:200; fig 1	Zeng M, Southern P, Reilly C, Beilman G, Chipman J, Schacker T, et al. Lymphoid tissue damage in HIV-1 infection depletes naïve T cells and limits T cell reconstitution after antiretroviral therapy. PLoS Pathog. 2012;8:e1002437 pubmed publisher
immunocytochemistry; human; 1:100	Wei Y, Zeng W, Wan R, Wang J, Zhou Q, Qiu S, et al. Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix. Eur Cell Mater. 2012;23:1-12 pubmed
immunohistochemistry; dogs	Tsuchiya T, Suzuki K, Hojo Y, Shiraki A, Imaoka M, Shibutani M, et al. Low-grade myofibroblastic sarcoma of the maxillary region in a dog. J Comp Pathol. 2012;147:42-5 pubmed publisher
immunohistochemistry; human	Ersoz S, Turgutalp H, Mungan S, Güvendı G, Guven S. Cotyledonoid leiomyoma of uterus: a case report. Turk Patoloji Derg. 2011;27:257-60 pubmed publisher
immunocytochemistry; human; 1:100	Stadler G, Chen J, Wagner K, Robin J, Shay J, Emerson C, et al. Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population. Skelet Muscle. 2011;1:12 pubmed publisher
immunohistochemistry; domestic sheep; 1:50	Gulbahar M, Kabak Y, Karayigit M, Yarim M, Guvenc T, Parlak U. The expressions of HSP70 and αB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs. J Vet Sci. 2011;12:65-73 pubmed
immunohistochemistry; human; 1:200	Clay M, Gibson P, Lowell J, Cooper K. Microscopic uterine lymphangioleiomyomatosis perivascular epithelioid cell neoplasm: a case report with the earliest manifestation of this enigmatic neoplasm. Int J Gynecol Pathol. 2011;30:71-5 pubmed publisher
immunohistochemistry; human	Angiero F. Ectomesenchymal chondromyxoid tumour of the tongue. A review of histological and immunohistochemical features. Anticancer Res. 2010;30:4685-9 pubmed
immunohistochemistry; rat	Karaoz E, Okcu A, Saglam O, Genc Z, Ayhan S, Kasap M. Pancreatic islet derived stem cells can express co-stimulatory molecules of antigen-presenting cells. Transplant Proc. 2010;42:3663-70 pubmed publisher
immunohistochemistry; rat	Adas G, Arikan S, Karatepe O, Kemik O, Ayhan S, Karaoz E, et al. Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study). Langenbecks Arch Surg. 2011;396:115-26 pubmed publisher
immunocytochemistry; human; 1:1	Karaoz E, Okçu A, Gacar G, Sağlam O, Yuruker S, Kenar H. A comprehensive characterization study of human bone marrow mscs with an emphasis on molecular and ultrastructural properties. J Cell Physiol. 2011;226:1367-82 pubmed publisher
immunohistochemistry; human; 1:100	Giordano G, Lombardi M, Brigati F, Mancini C, Silini E. Clinicopathologic features of 2 new cases of uterine tumors resembling ovarian sex cord tumors. Int J Gynecol Pathol. 2010;29:459-67 pubmed publisher
immunohistochemistry; human	Suzuki M, Tominaga N, Ide Y, Ohyama A, Nakahara T, Ishikawa H, et al. Establishment and characterization of the rhabdomyosarcoma cell line designated NUTOS derived from the human tongue sarcoma: Special reference to the susceptibility of anti-cancer drugs. Hum Cell. 2010;23:65-73 pubmed publisher
immunocytochemistry; human; 1:100	Carvajal Vergara X, Sevilla A, D Souza S, Ang Y, Schaniel C, Lee D, et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature. 2010;465:808-12 pubmed publisher
immunohistochemistry; human	Merfeld Clauss S, Gollahalli N, March K, Traktuev D. Adipose tissue progenitor cells directly interact with endothelial cells to induce vascular network formation. Tissue Eng Part A. 2010;16:2953-66 pubmed publisher
immunocytochemistry; human; 1:100	Vermeulen L, De Sousa E Melo F, van der Heijden M, Cameron K, de Jong J, Borovski T, et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol. 2010;12:468-76 pubmed publisher
immunohistochemistry; human; 1:100	Behzatoglu K, Durak H, Canberk S, Aydin O, Huq G, Oznur M, et al. Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma?. Diagn Pathol. 2009;4:48 pubmed publisher
immunohistochemistry; rhesus macaque	Starost M. Adenomyofibroma of the fimbria in a cynomolgus monkey (Macaca fascicularis). J Vet Diagn Invest. 2009;21:892-4 pubmed
immunohistochemistry; human	Türköz H, Alkan I, Sişman S, Ozcan D. Cyclooxygenase-2 expression and connection with tumor recurrence and histopathologic parameters in gastrointestinal stromal tumors. APMIS. 2009;117:825-30 pubmed publisher
immunohistochemistry; human	Ou M, Kim T, Yockman J, Borden B, Bull D, Kim S. Polymer transfected primary myoblasts mediated efficient gene expression and angiogenic proliferation. J Control Release. 2010;142:61-9 pubmed publisher
immunocytochemistry; human	Karaoz E, Doğan B, Aksoy A, Gacar G, Akyuz S, Ayhan S, et al. Isolation and in vitro characterisation of dental pulp stem cells from natal teeth. Histochem Cell Biol. 2010;133:95-112 pubmed publisher
immunocytochemistry; rat	Karaoz E, Aksoy A, Ayhan S, Sariboyaci A, Kaymaz F, Kasap M. Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers. Histochem Cell Biol. 2009;132:533-46 pubmed publisher
immunohistochemistry; human; 1:50	Kapucuoglu N, Percinel S, Ventura T, Lang R, Al Daraji W, Eusebi V. Dendritic cell sarcomas/tumours of the breast: report of two cases. Virchows Arch. 2009;454:333-9 pubmed publisher
immunohistochemistry; human	Gasparotto D, Rossi S, Bearzi I, Doglioni C, Marzotto A, Hornick J, et al. Multiple primary sporadic gastrointestinal stromal tumors in the adult: an underestimated entity. Clin Cancer Res. 2008;14:5715-21 pubmed publisher
immunohistochemistry; human	Russell M, Flynt F, Harroff A, Fadare O. Dedifferentiated Liposarcoma of the Retroperitoneum with Extensive Leiomyosarcomatous Differentiation and beta-Human Chorionic Gonadotropin Production. Sarcoma. 2008;2008:658090 pubmed publisher
immunohistochemistry; human; 1:50	Yorulmaz G, Erdogan G, Pestereli H, Savas B, Karaveli F. Epithelioid leiomyosarcoma with rhabdoid features. Wien Klin Wochenschr. 2007;119:557-60 pubmed
immunocytochemistry; mouse; 1:100	Xiang A, Mao F, Li W, Park D, Ma B, Wang T, et al. Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent host. Hum Mol Genet. 2008;17:27-37 pubmed
immunocytochemistry; human	Chi J, Rodriguez E, Wang Z, Nuyten D, Mukherjee S, van de Rijn M, et al. Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers. PLoS Genet. 2007;3:1770-84 pubmed
immunohistochemistry; cat; 1:75	Firat I, Haktanir Yatkin D, Sontas B, Ekici H. Vulvar leiomyosarcoma in a cat. J Feline Med Surg. 2007;9:435-8 pubmed
immunohistochemistry; human; 1:40	Gun B, Bahadir B, Behzatoglu K, Gun M, Ozdamar S. Elastofibroma: a clinicopathologic and immunohistochemical study of seven cases and literature review. APMIS. 2007;115:115-9 pubmed
immunohistochemistry; human	Vardar E, Gunlusoy B, Arslan M, Kececi S. Myointimoma of the glans penis. Pathol Int. 2007;57:158-61 pubmed
immunohistochemistry; human	Diniz G, Aktas S, Ortac R, Tunakan M, Unlu I, Vergin C. Kit expression in spindle cell rhabdomyosarcoma can possibly create a different approach for its tumorigenesis and therapy. Pathol Res Pract. 2006;202:671-7 pubmed
immunohistochemistry; domestic rabbit; 1:25	Karaboga R, Kilic O, Yaman O, Percinel S, Anafarta K. Long-term effect of experimental hypercholesterolemia on cavernosal tissues. Urology. 2006;67:431-4 pubmed
immunohistochemistry; human	Yesim G, Gupse T, Zafer U, Ahmet A. Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients. J Hepatobiliary Pancreat Surg. 2005;12:502-7 pubmed
immunohistochemistry - paraffin section; human immunohistochemistry; human	Guarino M, Ballabio G, Rubino B, Nebuloni M, Tosoni A. Soft tissue sacrococcygeal chordoma with intracytoplasmic filamentous inclusions. Pathol Res Pract. 2005;201:699-704 pubmed
immunohistochemistry; human; 1:50	Usubutun A, Karaman N, Ayhan A, Kucukali T. Atypical endometrial stromal cells related with a polypoid leiomyoma with bizarre nuclei: a case report. Int J Gynecol Pathol. 2005;24:352-4 pubmed
immunohistochemistry; human; 1:150	Saglam E, Usubutun A, Kart C, Ayhan A, Kucukali T. Reactive nodular fibrous pseudotumor involving the pelvic and abdominal cavity: a case report and review of literature. Virchows Arch. 2005;447:879-82 pubmed
immunohistochemistry; human	Uluoglu O, Akyurek N, Uner A, Coskun U, Ozdemir A, Gokcora N. Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature. Virchows Arch. 2005;446:546-54 pubmed
immunohistochemistry; human; 1:150	Ozguc H, Yilmazlar T, Yerci O, Soylu R, Tümay V, Filiz G, et al. Analysis of prognostic and immunohistochemical factors in gastrointestinal stromal tumors with malignant potential. J Gastrointest Surg. 2005;9:418-29 pubmed
immunohistochemistry - paraffin section; human; 1:50	Damiani S, Eusebi V, Peterse J. Malignant neoplasms infiltrating pseudoangiomatous' stromal hyperplasia of the breast: an unrecognized pathway of tumour spread. Histopathology. 2002;41:208-15 pubmed
	Albrecht N, Jiang D, Akhanov V, Hobson R, Speer C, Robichaux M, et al. Rapid 3D-STORM imaging of diverse molecular targets in tissue. Cell Rep Methods. 2022;2:100253 pubmed publisher
	Zhao Y, Vuckovic M, Yoo H, Fox N, Rodriguez A, McKessy K, et al. Retinoic acid exerts sexually dimorphic effects on muscle energy metabolism and function. J Biol Chem. 2021;297:101101 pubmed publisher
	Cha M, Seo J, Kim H, Kim M, Yoon H, Jo S, et al. Early Changes in Rat Heart After High-Dose Irradiation: Implications for Antiarrhythmic Effects of Cardiac Radioablation. J Am Heart Assoc. 2021;10:e019072 pubmed publisher
	An J, Li L, Lee J, Yu S, Kim J, Lee J, et al. Urinary cMet as a prognostic marker in immunoglobulin A nephropathy. J Cell Mol Med. 2020;24:11158-11169 pubmed publisher
	Tachtsis B, Whitfield J, Hawley J, Hoffman N. Omega-3 Polyunsaturated Fatty Acids Mitigate Palmitate-Induced Impairments in Skeletal Muscle Cell Viability and Differentiation. Front Physiol. 2020;11:563 pubmed publisher
	Lv F, Li N, Kong M, Wu J, Fan Z, Miao D, et al. CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels. Front Cell Dev Biol. 2020;8:176 pubmed publisher
	Swärd K, Krawczyk K, Morén B, Zhu B, Matic L, Holmberg J, et al. Identification of the intermediate filament protein synemin/SYNM as a target of myocardin family coactivators. Am J Physiol Cell Physiol. 2019;317:C1128-C1142 pubmed publisher
	Takahashi A, Loo T, Okada R, Kamachi F, Watanabe Y, Wakita M, et al. Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells. Nat Commun. 2018;9:1249 pubmed publisher
	Hernandez D, Bennett C, Dunina Barkovskaya L, Wedig T, Capetanaki Y, Herrmann H, et al. Nebulette is a powerful cytolinker organizing desmin and actin in mouse hearts. Mol Biol Cell. 2016;27:3869-3882 pubmed
	Ertoy Baydar D, Kosemehmetoglu K, Aydin O, Bridge J, Buyukeren B, Aki F. Primary sclerosing epithelioid fibrosarcoma of kidney with variant histomorphologic features: report of 2 cases and review of the literature. Diagn Pathol. 2015;10:186 pubmed publisher
	Sauter J, Ambaye A, Mount S. Increased utilization, verification, and clinical implications of immunocytochemistry: Experience in a northern New England hospital. Diagn Cytopathol. 2015;43:688-95 pubmed publisher
	Ohlmann C, Brecht I, Junker K, van der Zee J, Nistor A, Bohle R, et al. Sclerosing epithelioid fibrosarcoma of the kidney: clinicopathologic and molecular study of a rare neoplasm at a novel location. Ann Diagn Pathol. 2015;19:221-5 pubmed publisher
	Baker L, Gillis D, Sharma S, Ambrus A, Herrmann H, Conover G. Nebulin binding impedes mutant desmin filament assembly. Mol Biol Cell. 2013;24:1918-32 pubmed publisher
	Cui J, Chen S, Zhang C, Meng F, Wu W, Hu R, et al. Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia. Mol Neurodegener. 2012;7:21 pubmed publisher
	Martínez Fernández B, Garcia Iglesias M, Borragán Santos S, Espinosa Alvarez J, Perez Martinez C. Undifferentiated high-grade pleomorphic sarcoma in a California sea lion (Zalophus californianus). J Comp Pathol. 2011;144:200-3 pubmed publisher
	Mucciarini C, Rossi G, Bertolini F, Valli R, Cirilli C, Rashid I, et al. Incidence and clinicopathologic features of gastrointestinal stromal tumors. A population-based study. BMC Cancer. 2007;7:230 pubmed
	Gorbe A, Becker D, Dux L, Stelkovics E, Krenacs L, Bagdi E, et al. Transient upregulation of connexin43 gap junctions and synchronized cell cycle control precede myoblast fusion in regenerating skeletal muscle in vivo. Histochem Cell Biol. 2005;123:573-83 pubmed
	Dagli M, Eryilmaz A, Acar A, Kulacoglu S, Akmansu H. Collagenous fibroma (desmoplastic fibroblastoma). Yonsei Med J. 2004;45:941-3 pubmed
	Pai S, Zaveri S. Intra-abdominal fibromatosis of the jejunum and mesentery. J Clin Pathol. 2004;57:1119 pubmed
	Bildirici K, Donmez T, Gürlek E. Inflammatory pseudotumor of the kidney. Int Urol Nephrol. 2004;36:141-3 pubmed
	Chi J, Chang H, Haraldsen G, Jahnsen F, Troyanskaya O, Chang D, et al. Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci U S A. 2003;100:10623-8 pubmed
	Di Tommaso L, Pasquinelli G, Damiani S. Smooth muscle cell differentiation in mammary stromo-epithelial lesions with evidence of a dual origin: stromal myofibroblasts and myoepithelial cells. Histopathology. 2003;42:448-56 pubmed
	Kadner A, Hoerstrup S, Tracy J, Breymann C, Maurus C, Melnitchouk S, et al. Human umbilical cord cells: a new cell source for cardiovascular tissue engineering. Ann Thorac Surg. 2002;74:S1422-8 pubmed
	Hoerstrup S, Kadner A, Melnitchouk S, Trojan A, Eid K, Tracy J, et al. Tissue engineering of functional trileaflet heart valves from human marrow stromal cells. Circulation. 2002;106:I143-50 pubmed
	Cinel L, Dusmez D, Nabaei S, Taner D, Pata O. Two intraligamentary lipomatous tumors with immunohistochemical features. Acta Obstet Gynecol Scand. 2002;81:786-7 pubmed
	Hoerstrup S, Kadner A, Breymann C, Maurus C, Guenter C, Sodian R, et al. Living, autologous pulmonary artery conduits tissue engineered from human umbilical cord cells. Ann Thorac Surg. 2002;74:46-52; discussion 52 pubmed
	Kadner A, Hoerstrup S, Zund G, Eid K, Maurus C, Melnitchouk S, et al. A new source for cardiovascular tissue engineering: human bone marrow stromal cells. Eur J Cardiothorac Surg. 2002;21:1055-60 pubmed

image

image 1 :

Formalin-fixed, paraffin-embedded human leiomyoma stained with Desmin antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of muscle cells.

image 2 :

Formalin-fixed, paraffin-embedded rat bladder stained with Desmin antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of muscle cells.

image 3 :

product information

Product Type :

Antibody

Product Name :

Desmin Monoclonal Antibody (D33)

Catalog # :

MA5-13259

Quantity :

500 µL

Price :

US 431

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Bovine, Canine, Chicken, Feline, Hamster, Human, Non-human primate, Rat

Applications :

Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:50-1:100

Species :

Bovine, Canine, Chicken, Feline, Hamster, Human, Non-human primate, Rat

Clone :

D33

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.

Immunogen :

Desmin from human muscle

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:50-1:100

Aliases :

CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin

more info or order :

Invitrogen product webpage