CD30 Monoclonal Antibody (Ber-H2) | Invitrogen MA5-13219 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD30 Monoclonal Antibody (Ber-H2)

catalog :

MA5-13219

quantity :

500 µL

price :

US 421

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Ber-H2

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:50	Yang Y, Li Y, Liu Y, Yang M, Liu K. CD30+ extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report. Oncol Lett. 2014;7:1419-1421 pubmed
immunohistochemistry; human; 1:50	Wang T, Xu C, Liu S, Kan B, Ran Y, Liu W, et al. Clinicopathology, immunophenotype, T cell receptor gene rearrangement, Epstein-Barr virus status and p53 gene mutation of cutaneous extranodal NK/T-cell lymphoma, nasal-type. Chin Med J (Engl). 2013;126:1281-7 pubmed
immunohistochemistry; human; 1:100	Yu G, Kong L, Qu G, Zhang Q, Wang W, Jiang L. Composite lymphoma in the anterior mediastinum: a case report and review of the literature. Diagn Pathol. 2011;6:60 pubmed publisher
immunohistochemistry; human; 1:40	Jung S, Yim S, Hu H, Jung C, Lee S, Kim D, et al. Copy number alterations and expression profiles of candidate genes in a pulmonary inflammatory myofibroblastic tumor. Lung Cancer. 2010;70:152-7 pubmed publisher
immunohistochemistry; human	Horváth E, Mezei T, Pávai Z, Turcu M, Demian S, Toth E, et al. Diagnostic and differential diagnostic criteria of lymphoid neoplasms in bone marrow trephine biopsies: a study of 87 cases. Rom J Morphol Embryol. 2009;50:399-406 pubmed
immunohistochemistry; human	Cattoretti G, Büttner M, Shaknovich R, Kremmer E, Alobeid B, Niedobitek G. Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells. Blood. 2006;107:3967-75 pubmed
immunohistochemistry; human; 1 ug/ml	Cattoretti G, Angelin Duclos C, Shaknovich R, Zhou H, Wang D, Alobeid B. PRDM1/Blimp-1 is expressed in human B-lymphocytes committed to the plasma cell lineage. J Pathol. 2005;206:76-86 pubmed
	Wurster K, Hummel F, Richter J, Giefing M, Hartmann S, Hansmann M, et al. Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma. Leukemia. 2017;31:602-613 pubmed publisher
	Torres Cabala C, Curry J, Li Ning Tapia E, Ramos C, Tetzlaff M, Prieto V, et al. HTLV-1-associated infective dermatitis demonstrates low frequency of FOXP3-positive T-regulatory lymphocytes. J Dermatol Sci. 2015;77:150-5 pubmed publisher
	Oz Puyan F, Bilgi S, Unlu E, Yalcin O, Altaner S, Demir M, et al. Inflammatory pseudotumor of the spleen with EBV positivity: report of a case. Eur J Haematol. 2004;72:285-91 pubmed

image

image 1 :

Formalin-fixed, paraffin-embedded human Hodgkin’s lymphoma stained with CD30 antibody using peroxidase-conjugate and AEC chromogen. Note membrane and cytoplasmic staining of Reedternberg’s cells.

product information

Product Type :

Antibody

Product Name :

CD30 Monoclonal Antibody (Ber-H2)

Catalog # :

MA5-13219

Quantity :

500 µL

Price :

US 421

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:40-1:80

Species :

Human

Clone :

Ber-H2

Isotype :

IgG1, kappa

Storage :

4° C

Description :

CD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. CD30 is a positive regulator of apoptosis, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. CD30 is expressed by mononuclear cells in Hodgkin's lymphoma, Reed Sternberg cells and most Anaplastic Large Cell Lymphomas (ALCL). CD30 is also expressed by embryonal carcinomas.

Immunogen :

Co cells

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:40-1:80

Aliases :

Ber-H2; Cd30; CD30 antigen; CD30 molecule; CD30L receptor; cytokine receptor CD30; D1S166E; Ki; Ki-1; Ki-1 antigen; Lymphocyte activation antigen CD30; sCD30; soluble CD30; TNF receptor superfamily member 8; TNFRSF8; Tumor necrosis factor receptor superfamily member 8; tumor necrosis factor receptor superfamily, member 8; Tumor necrosis factor superfamily member 8; tumor necrosis factor superfamily, member CD30

more info or order :

Invitrogen product webpage