CD45 Antibody Cocktail | Invitrogen MA5-13197 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD45 Antibody Cocktail

catalog :

MA5-13197

quantity :

500 uL

price :

US 371.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PD7/26/16, 2B11

reactivity :

human, mouse

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; 1:500; fig 2e	Lim K, Dayem A, Choi Y, Lee Y, An J, Gil M, et al. High Therapeutic and Esthetic Properties of Extracellular Vesicles Produced from the Stem Cells and Their Spheroids Cultured from Ocular Surgery-Derived Waste Orbicularis Oculi Muscle Tissues. Antioxidants (Basel). 2021;10: pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig 1a	Szalayova G, Ogrodnik A, Spencer B, Wade J, Bunn J, Ambaye A, et al. Human breast cancer biopsies induce eosinophil recruitment and enhance adjacent cancer cell proliferation. Breast Cancer Res Treat. 2016;157:461-74 pubmed publisher
immunohistochemistry; mouse	Singh M, Singh P, Gaudray G, Musumeci L, Thielen C, Vaira D, et al. An improved protocol for efficient engraftment in NOD/LTSZ-SCIDIL-2R?null mice allows HIV replication and development of anti-HIV immune responses. PLoS ONE. 2012;7:e38491 pubmed publisher
immunohistochemistry; human; 1:100	Yu G, Kong L, Qu G, Zhang Q, Wang W, Jiang L. Composite lymphoma in the anterior mediastinum: a case report and review of the literature. Diagn Pathol. 2011;6:60 pubmed publisher
flow cytometry; human	Proia T, Keller P, Gupta P, Klebba I, Jones A, Sedic M, et al. Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell. 2011;8:149-63 pubmed publisher
flow cytometry; human; 1:50	Zhao J, Gao Z, Mei H, Li Y, Wang Y. Differentiation of human mesenchymal stem cells: the potential mechanism for estrogen-induced preferential osteoblast versus adipocyte differentiation. Am J Med Sci. 2011;341:460-8 pubmed publisher
immunohistochemistry; human	Balci S, Engiz O, Okten G, Sipahier M, Gursu G, Kandemir B. A 19-year follow-up of a patient with type 3 ectrodactyly-ectodermal dysplasia-clefting syndrome who developed non-Hodgkin lymphoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:e91-5 pubmed publisher
flow cytometry; human	He X, Li Y, Wang X, Guo X, Niu Y. [Mesenchymal stem cells transduced by PLEGFP-N1 retroviral vector maintain their biological features and differentiation]. Chin Med J (Engl). 2005;118:1728-34 pubmed
immunohistochemistry; human	Gucer F, Altaner S, Mulayim N, Yapicier O. Invasive inflammatory pseudotumor of uterine cervix: a case report. Gynecol Oncol. 2005;98:325-8 pubmed
immunohistochemistry; human	Zhang Y, Yuan F, Jia G, Zhang J, Hu L, Huang L, et al. CIK cells from patients with HCC possess strong cytotoxicity to multidrug-resistant cell line Bel-7402/R. World J Gastroenterol. 2005;11:3339-45 pubmed
	Masuda T, Maeda S, Shimada S, Sakuramoto N, Morita K, Koyama A, et al. RUNX1 transactivates BCR-ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia. Cancer Sci. 2022;113:529-539 pubmed publisher
	Beccard I, Hofmann L, Schroeder J, Ludwig S, Laban S, Brunner C, et al. Immune Suppressive Effects of Plasma-Derived Exosome Populations in Head and Neck Cancer. Cancers (Basel). 2020;12: pubmed publisher
	Pinto A, Ilinykh A, Ivey M, Kuwabara J, D Antoni M, Debuque R, et al. Revisiting Cardiac Cellular Composition. Circ Res. 2016;118:400-9 pubmed publisher
	Kersemaekers A, Van Weeren P, Oosterhuis J, Looijenga L. Involvement of the Fas/FasL pathway in the pathogenesis of germ cell tumours of the adult testis. J Pathol. 2002;196:423-9 pubmed

product information

Product Type :

Antibody

Product Name :

CD45 Antibody Cocktail

Catalog # :

MA5-13197

Quantity :

500 uL

Price :

US 371.00

Clonality :

Cocktail

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.5 ug/test, Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:10-1:100

Species :

Human

Clone :

PD7/26/16, 2B11

Isotype :

IgG1, kappa

Storage :

4 C

Description :

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.

Immunogen :

PD7/26/16: human peripheral blood lymphocytes maintained in T cell growth factor. 2B11: isolated neoplastic cells from T cell lymphoma.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test, Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:10-1:100

Aliases :

B220; cd45; CD45 antigen; CD45 antigen isoform 1 precursor; CD45 antigen isoform 2 precursor; CD45 antigen isoform 3 precursor; CD45 antigen isoform 4 precursor; CD45 antigen isoform 5 precursor; CD45 antigen isoform 6 precursor; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; leukocyte common antigen, CD45; loc; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase lambda; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; protein tyrosine phosphatase; alternatively spliced; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen; T220 and B220

more info or order :

Invitrogen product webpage