This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Estrogen Receptor alpha Monoclonal Antibody (1D5)
catalog :
MA5-13191
quantity :
500 µL
price :
US 646
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1D5
reactivity :
African green monkey, human, mouse, rat, chicken, cat, domestic rabbit, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, EMSA, immunohistochemistry - paraffin section
citations: 82
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:50; loading ...
Carvajal Hausdorf D, Mani N, Velcheti V, Schalper K, Rimm D. Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer. J Immunother Cancer. 2017;5:81 pubmed publisher
  • immunocytochemistry; human; 1:25; fig 6
Hopkinson B, Klitgaard M, Petersen O, Villadsen R, Rønnov Jessen L, Kim J. Establishment of a normal-derived estrogen receptor-positive cell line comparable to the prevailing human breast cancer subtype. Oncotarget. 2017;8:10580-10593 pubmed publisher
  • western blot; human; 1:500; loading ...; tbl 1
Cardoso R, Burns A, Moeller J, Skinner D, Padmanabhan V. Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS. Endocrinology. 2016;157:4641-4653 pubmed
  • immunohistochemistry; human; 1:300; fig 2
Lu B, Chen Q, Zhang X, Cheng L. Serous carcinoma arising from uterine adenomyosis/adenomyotic cyst of the cervical stump: a report of 3 cases. Diagn Pathol. 2016;11:46 pubmed publisher
  • immunohistochemistry; human; 1:200
Khandakar B, Mathur S, Kumar L, Kumar S, Datta Gupta S, Iyer V, et al. Tissue biomarkers in prognostication of serous ovarian cancer following neoadjuvant chemotherapy. Biomed Res Int. 2014;2014:401245 pubmed publisher
  • EMSA; human
Kruer T, Cummins T, Powell D, Wittliff J. Characterization of estrogen response element binding proteins as biomarkers of breast cancer behavior. Clin Biochem. 2013;46:1739-46 pubmed publisher
  • immunohistochemistry; human; 1:50
Grosso S, Katayama M, Roela R, Nonogaki S, Soares F, Brentani H, et al. Breast cancer tissue slices as a model for evaluation of response to rapamycin. Cell Tissue Res. 2013;352:671-84 pubmed publisher
  • western blot; human
Endoh T, Kawasaki Y, Sugimoto N. Stability of RNA quadruplex in open reading frame determines proteolysis of human estrogen receptor ?. Nucleic Acids Res. 2013;41:6222-31 pubmed publisher
  • immunohistochemistry; human; tbl 1
Zhao Y, Li W, Lang R, Yang Y, Gao X, Zheng Y, et al. Primary acinic cell carcinoma of the breast: a case report and review of the literature. Int J Surg Pathol. 2014;22:177-81 pubmed publisher
  • immunohistochemistry; human
  • western blot; human
Li Y, Meeran S, Patel S, Chen H, Hardy T, Tollefsbol T. Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. Mol Cancer. 2013;12:9 pubmed publisher
  • immunohistochemistry; human; 1:500
Laliotis A, Vrekoussis T, Kafousi M, Sanidas E, Askoxilakis J, Melissas J, et al. Immunohistochemical study of pElk-1 expression in human breast cancer: association with breast cancer biologic profile and clinicopathologic features. Breast. 2013;22:89-95 pubmed publisher
  • immunocytochemistry; human; 1:35
Marinšek Z, Nolde N, Kardum Skelin I, Nizzoli R, Onal B, Rezanko T, et al. Multinational study of oestrogen and progesterone receptor immunocytochemistry on breast carcinoma fine needle aspirates. Cytopathology. 2013;24:7-20 pubmed publisher
  • immunohistochemistry; human; 1:100
Marian C, Boilă A, Soanca D, Malau M, Podeanu D, Resetkova E, et al. Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature. APMIS. 2013;121:272-9 pubmed publisher
  • immunohistochemistry; human
Gill M, Paish E, Ronan J, Green A, Ellis I, Lee A. Comparison of the PharmDx immunohistochemical system with standard methods for assessing estrogen and progesterone receptors in invasive carcinoma of the breast. Appl Immunohistochem Mol Morphol. 2013;21:90-3 pubmed publisher
  • immunohistochemistry; chicken; 1:200
Machado S, Bahr J, Hales D, Braundmeier A, Quade B, Nowak R. Validation of the aging hen (Gallus gallus domesticus) as an animal model for uterine leiomyomas. Biol Reprod. 2012;87:86 pubmed publisher
  • immunohistochemistry; rhesus macaque
Almeida Francia C, Keator C, Mah K, Holden L, Hergert C, Slayden O. Localization and hormonal regulation of endometrial matrix metalloproteinase-26 in the rhesus macaque. Hum Reprod. 2012;27:1723-34 pubmed publisher
  • immunohistochemistry; human; 1:100
Hovanessian Larsen L, Taylor D, Hawes D, Spicer D, Press M, Wu A, et al. Lowering oral contraceptive norethindrone dose increases estrogen and progesterone receptor levels with no reduction in proliferation of breast epithelium: a randomized trial. Contraception. 2012;86:238-43 pubmed publisher
  • immunohistochemistry; human
Maae E, Olsen D, Steffensen K, Jakobsen E, Brandslund I, Sørensen F, et al. Prognostic impact of placenta growth factor and vascular endothelial growth factor A in patients with breast cancer. Breast Cancer Res Treat. 2012;133:257-65 pubmed publisher
  • immunohistochemistry; rat; 1:150
Einbond L, Soffritti M, Degli Esposti D, Tibaldi E, Lauriola M, Bua L, et al. Chemopreventive potential of black cohosh on breast cancer in Sprague-Dawley rats. Anticancer Res. 2012;32:21-30 pubmed
  • immunohistochemistry; human; 1:100
Chung K, Hovanessian Larsen L, Hawes D, Taylor D, Downey S, Spicer D, et al. Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation. Breast Cancer Res Treat. 2012;132:653-60 pubmed publisher
  • immunohistochemistry; human; 1:50
Rijlaarsdam M, van Herk H, Gillis A, Stoop H, Jenster G, Martens J, et al. Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours. Br J Cancer. 2011;105:854-63 pubmed publisher
  • immunohistochemistry; human
Shatalova E, Klein Szanto A, Devarajan K, Cukierman E, Clapper M. Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis. Cancer Prev Res (Phila). 2011;4:107-15 pubmed publisher
  • immunohistochemistry; human; 1:100
Gschwantler Kaulich D, Fink Retter A, Czerwenka K, Hudelist G, Kaulich A, Kubista E, et al. Differential expression pattern of estrogen receptors, aromatase, and sulfotransferase in breast cancer tissue and corresponding lymph node metastases. Tumour Biol. 2011;32:501-8 pubmed publisher
  • immunohistochemistry; rat; 1:100
WIEHLE R, Lantvit D, Yamada T, Christov K. CDB-4124, a progesterone receptor modulator, inhibits mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis. Cancer Prev Res (Phila). 2011;4:414-24 pubmed publisher
  • immunohistochemistry; human; 1:50
Joosse S, Brandwijk K, Mulder L, Wesseling J, Hannemann J, Nederlof P. Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors. Genes Chromosomes Cancer. 2011;50:71-81 pubmed publisher
  • immunohistochemistry; mouse
Habib F, Zaki M, El Aal A, Safwat M, Domiaty M. Immunohistochemical expression of oestrogen and progesterone receptors during experimental acute and chronic murine Schistosomiasis mansoni. Rev Soc Bras Med Trop. 2010;43:531-5 pubmed
  • western blot; human; 1:250
Byer S, Eckert J, Brossier N, Clodfelder Miller B, Turk A, Carroll A, et al. Tamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptor-independent manner. Neuro Oncol. 2011;13:28-41 pubmed publisher
  • immunohistochemistry; human; 1:50
Holstege H, van Beers E, Velds A, Liu X, Joosse S, Klarenbeek S, et al. Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers. BMC Cancer. 2010;10:455 pubmed publisher
  • immunohistochemistry; human; 1:50
Joosse S, Brandwijk K, Devilee P, Wesseling J, Hogervorst F, Verhoef S, et al. Prediction of BRCA2-association in hereditary breast carcinomas using array-CGH. Breast Cancer Res Treat. 2012;132:379-89 pubmed publisher
  • immunohistochemistry; human; 1:100
Balci S, Saglam A, Usubutun A. Primary signet-ring cell carcinoma of the cervix: case report and review of the literature. Int J Gynecol Pathol. 2010;29:181-4 pubmed publisher
  • immunohistochemistry; human
Ko E, Lee B, Kim H, Noh W, Kim M, Lee S. Triple-negative breast cancer: correlation between imaging and pathological findings. Eur Radiol. 2010;20:1111-7 pubmed publisher
  • immunohistochemistry; human; 1:200
  • western blot; human; 1:200
Jung J, Chae Y, Moon J, Kang B, Kim J, Sohn S, et al. TNF superfamily gene polymorphism as prognostic factor in early breast cancer. J Cancer Res Clin Oncol. 2010;136:685-94 pubmed publisher
  • immunohistochemistry; human; 1:50
Roepman P, Horlings H, Krijgsman O, Kok M, Bueno de Mesquita J, Bender R, et al. Microarray-based determination of estrogen receptor, progesterone receptor, and HER2 receptor status in breast cancer. Clin Cancer Res. 2009;15:7003-11 pubmed publisher
  • immunohistochemistry; human; 1:200
Hahn H, Yoon S, Hong J, Hong S, Park S, Lim J, et al. Conservative treatment with progestin and pregnancy outcomes in endometrial cancer. Int J Gynecol Cancer. 2009;19:1068-73 pubmed publisher
  • immunohistochemistry; human; 1:50
  • western blot; human; 1:500
Raso M, Behrens C, Herynk M, Liu S, Prudkin L, Ozburn N, et al. Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation. Clin Cancer Res. 2009;15:5359-68 pubmed publisher
  • immunohistochemistry; human; 1:200
Bueno de Mesquita J, Nuyten D, Wesseling J, VAN Tinteren H, Linn S, van de Vijver M. The impact of inter-observer variation in pathological assessment of node-negative breast cancer on clinical risk assessment and patient selection for adjuvant systemic treatment. Ann Oncol. 2010;21:40-7 pubmed publisher
  • immunohistochemistry; cat
Misirlioglu D, Nak D, Ozyigit M, Nak Y, Akkoc A. HER-2/neu (c-erbB-2) oncoprotein in hyperplastic endometrial polyps detected in two cats. J Feline Med Surg. 2009;11:885-8 pubmed publisher
  • immunohistochemistry; mouse
Chen J, Kwon C, Lin L, Li Y, Parada L. Inducible site-specific recombination in neural stem/progenitor cells. Genesis. 2009;47:122-31 pubmed publisher
  • immunohistochemistry; human; 1:50
Pietersen A, Horlings H, Hauptmann M, Langerød A, Ajouaou A, Cornelissen Steijger P, et al. EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer. Breast Cancer Res. 2008;10:R109 pubmed publisher
  • immunohistochemistry; human; 1:100
Ceausu M, Terzea D, Georgescu A, Dobrea C, Mihai M, Iosif C, et al. Transitional cell tumors of the ovary: a compact group with a heterogeneous histological and immunophenotypical pattern. Rom J Morphol Embryol. 2008;49:513-6 pubmed
  • immunohistochemistry; rat
Matagne V, Mastronardi C, Shapiro R, Dorsa D, Ojeda S. Hypothalamic expression of Eap1 is not directly controlled by ovarian steroids. Endocrinology. 2009;150:1870-8 pubmed publisher
  • immunohistochemistry; human; 1:400
Wang R, Wen M, Wang J, Ho S, Jan Y. Osteosarcoma arising in a long-standing uterine leiomyoma: a case report and literature review. Int J Surg Pathol. 2011;19:99-103 pubmed publisher
  • immunohistochemistry; human; 1:400
Zhou M, Kort E, Hoekstra P, Westphal M, Magi Galluzzi C, Sercia L, et al. Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence. Am J Surg Pathol. 2009;33:72-80 pubmed publisher
  • immunohistochemistry; human; 1:100
Chakravarty D, Srinivasan R, Ghosh S, Rajwanshi A, Gopalan S. Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma. Appl Immunohistochem Mol Morphol. 2008;16:535-42 pubmed publisher
  • immunohistochemistry; human; 1:50
Joosse S, van Beers E, Tielen I, Horlings H, Peterse J, Hoogerbrugge N, et al. Prediction of BRCA1-association in hereditary non-BRCA1/2 breast carcinomas with array-CGH. Breast Cancer Res Treat. 2009;116:479-89 pubmed publisher
  • immunohistochemistry; domestic rabbit; 1:50
Onal B, Levin R, Kogan B, Whitbeck C, Chichester P, Walebowa O, et al. The effect of maturation and age on oestrogen-induced functional hypertrophy of the female rabbit bladder. BJU Int. 2007;99:674-9 pubmed
  • immunohistochemistry; human; 1:100
Singer C, Fink Retter A, Gschwantler Kaulich D, Thalhammer T, Hudelist G, Mueller R, et al. Selective spatial upregulation of intratumoral stromal aromatase in breast cancer patients: evidence for imbalance of local estrogen metabolism. Endocr Relat Cancer. 2006;13:1101-7 pubmed
  • immunohistochemistry; human
Schmidt M, Tollenaar R, de Kemp S, Broeks A, Cornelisse C, Smit V, et al. Breast cancer survival and tumor characteristics in premenopausal women carrying the CHEK2*1100delC germline mutation. J Clin Oncol. 2007;25:64-9 pubmed
  • immunohistochemistry; human; 1:50
Hannemann J, Kristel P, VAN Tinteren H, Bontenbal M, van Hoesel Q, Smit W, et al. Molecular subtypes of breast cancer and amplification of topoisomerase II alpha: predictive role in dose intensive adjuvant chemotherapy. Br J Cancer. 2006;95:1334-41 pubmed
  • immunohistochemistry; human
Wang M, Pan J, Song G, Chen H, An L, Qu S. Altered expression of estrogen receptor alpha and beta in advanced gastric adenocarcinoma: correlation with prothymosin alpha and clinicopathological parameters. Eur J Surg Oncol. 2007;33:195-201 pubmed
  • immunohistochemistry; human; 1:200
Amant F, Woestenborghs H, Vandenbroucke V, Berteloot P, Neven P, Moerman P, et al. Transition of endometrial stromal sarcoma into high-grade sarcoma. Gynecol Oncol. 2006;103:1137-40 pubmed
  • immunohistochemistry - paraffin section; human; 1:200
Rao K, Alper O, Opheim K, Bonnet G, Wolfe K, Bryant E, et al. Cytogenetic characterization and H-ras associated transformation of immortalized human mammary epithelial cells. Cancer Cell Int. 2006;6:15 pubmed
  • western blot; human; 1:100
Turbyville T, Wijeratne E, Liu M, Burns A, Seliga C, Luevano L, et al. Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. J Nat Prod. 2006;69:178-84 pubmed
  • immunohistochemistry; human; 1:400
Tse G, Tan P, Putti T, Lui P, Chaiwun B, Law B. Metaplastic carcinoma of the breast: a clinicopathological review. J Clin Pathol. 2006;59:1079-83 pubmed
  • immunohistochemistry; mouse; 1:50
Wang R, Zhang H, Balasenthil S, Medina D, Kumar R. PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene. 2006;25:2931-6 pubmed
  • western blot; human; 1:750
  • immunocytochemistry; African green monkey; 1:200
Lipfert L, Fisher J, Wei N, Scafonas A, Su Q, Yudkovitz J, et al. Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation. Mol Endocrinol. 2006;20:516-33 pubmed
  • immunohistochemistry; human
Saylam G, Yücel O, Sungur A, Onerci M. Proliferation, angiogenesis and hormonal markers in juvenile nasopharyngeal angiofibroma. Int J Pediatr Otorhinolaryngol. 2006;70:227-34 pubmed
  • immunohistochemistry; human; 1:100
Saglam E, Usubutun A, Kart C, Ayhan A, Kucukali T. Reactive nodular fibrous pseudotumor involving the pelvic and abdominal cavity: a case report and review of literature. Virchows Arch. 2005;447:879-82 pubmed
  • immunohistochemistry; human; 1:100
Akhan S, Yavuz E, Tecer A, Iyibozkurt C, Topuz S, Tuzlali S, et al. The expression of Ki-67, p53, estrogen and progesterone receptors affecting survival in uterine leiomyosarcomas. A clinicopathologic study. Gynecol Oncol. 2005;99:36-42 pubmed
  • western blot; human
Wittmann B, Fujinaga K, Deng H, Ogba N, Montano M. The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1. Oncogene. 2005;24:5576-88 pubmed
  • immunohistochemistry; mouse; 1:200
Dinulescu D, Ince T, Quade B, Shafer S, Crowley D, Jacks T. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med. 2005;11:63-70 pubmed
McGlade E, Herrera G, Stephens K, Olsen S, Winuthayanon S, Guner J, et al. Cell-type specific analysis of physiological action of estrogen in mouse oviducts. FASEB J. 2021;35:e21563 pubmed publisher
Griffiths R, Pru C, Behura S, Cronrath A, McCallum M, Kelp N, et al. AMPK is required for uterine receptivity and normal responses to steroid hormones. Reproduction. 2020;159:707-717 pubmed publisher
Dunphy K, Black A, Roberts A, Sharma A, Li Z, Suresh S, et al. Inter-Individual Variation in Response to Estrogen in Human Breast Explants. J Mammary Gland Biol Neoplasia. 2020;25:51-68 pubmed publisher
Herrera G, Lierz S, Harris E, Donoghue L, Hewitt S, Rodriguez K, et al. Oviductal Retention of Embryos in Female Mice Lacking Estrogen Receptor α in the Isthmus and the Uterus. Endocrinology. 2020;161: pubmed publisher
Li S, Herrera G, Tam K, Lizarraga J, Beedle M, Winuthayanon W. Estrogen Action in the Epithelial Cells of the Mouse Vagina Regulates Neutrophil Infiltration and Vaginal Tissue Integrity. Sci Rep. 2018;8:11247 pubmed publisher
Papachristou E, Kishore K, Holding A, Harvey K, Roumeliotis T, Chilamakuri C, et al. A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes. Nat Commun. 2018;9:2311 pubmed publisher
Mungenast F, Aust S, Vergote I, Vanderstichele A, Sehouli J, Braicu E, et al. Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer. Oncol Lett. 2017;13:4047-4054 pubmed publisher
Li S, Garcia M, Gewiss R, Winuthayanon W. Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo. PLoS Genet. 2017;13:e1006743 pubmed publisher
Choi E, Kim D, Kim J, Kim D, Kim J, Seol O, et al. Estrogen-dependent transcription of the NEL-like 2 (NELL2) gene and its role in protection from cell death. J Biol Chem. 2010;285:25074-84 pubmed publisher
Flötotto T, Niederacher D, Hohmann D, Heimerzheim T, Dall P, Djahansouzi S, et al. Molecular mechanism of estrogen receptor (ER)alpha-specific, estradiol-dependent expression of the progesterone receptor (PR) B-isoform. J Steroid Biochem Mol Biol. 2004;88:131-42 pubmed
Guler G, Uner A, Guler N, Han S, Iliopoulos D, Hauck W, et al. The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. Cancer. 2004;100:1605-14 pubmed
Kapucuoglu N, Coban T, Raunio H, Pelkonen O, Edwards R, Boobis A, et al. Expression of CYP3A4 in human breast tumour and non-tumour tissues. Cancer Lett. 2003;202:17-23 pubmed
Beliakoff J, Bagatell R, Paine Murrieta G, Taylor C, Lykkesfeldt A, Whitesell L. Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors. Clin Cancer Res. 2003;9:4961-71 pubmed
Wittmann B, Wang N, Montano M. Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors. Cancer Res. 2003;63:5151-8 pubmed
Wang H, Mahadevappa M, Yamamoto K, Wen Y, Chen B, Warrington J, et al. Distinctive proliferative phase differences in gene expression in human myometrium and leiomyomata. Fertil Steril. 2003;80:266-76 pubmed
Bethea C, Lu N, Reddy A, Shlaes T, Streicher J, Whittemore S. Characterization of reproductive steroid receptors and response to estrogen in a rat serotonergic cell line. J Neurosci Methods. 2003;127:31-41 pubmed
Hudelist G, Czerwenka K, Kubista E, Marton E, Pischinger K, Singer C. Expression of sex steroid receptors and their co-factors in normal and malignant breast tissue: AIB1 is a carcinoma-specific co-activator. Breast Cancer Res Treat. 2003;78:193-204 pubmed
Seth P, Porter D, Lahti Domenici J, Geng Y, Richardson A, Polyak K. Cellular and molecular targets of estrogen in normal human breast tissue. Cancer Res. 2002;62:4540-4 pubmed
Suzuki T, Darnel A, Akahira J, Ariga N, Ogawa S, Kaneko C, et al. 5alpha-reductases in human breast carcinoma: possible modulator of in situ androgenic actions. J Clin Endocrinol Metab. 2001;86:2250-7 pubmed
El Khissiin A, Journe F, Laios I, Seo H, Leclercq G. Evidence of an estrogen receptor form devoid of estrogen binding ability in MCF-7 cells. Steroids. 2000;65:903-13 pubmed
Lu N, Shlaes T, Gundlah C, Dziennis S, Lyle R, Bethea C. Ovarian steroid action on tryptophan hydroxylase protein and serotonin compared to localization of ovarian steroid receptors in midbrain of guinea pigs. Endocrine. 1999;11:257-67 pubmed
product information
Product Type :
Antibody
Product Name :
Estrogen Receptor alpha Monoclonal Antibody (1D5)
Catalog # :
MA5-13191
Quantity :
500 µL
Price :
US 646
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human
Applications :
Immunocytochemistry: 1:500-1:1000, Immunofluorescence: 1:500-1:1000, Immunohistochemistry (Paraffin): 0.4-0.8 µg/mL, Western Blot: 0.5-1.0 µg/mL
Species :
Human
Clone :
1D5
Isotype :
IgG1, kappa
Storage :
4° C
Description :
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
Immunogen :
Recombinant human estrogen receptor protein
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:500-1:1000, Immunofluorescence: 1:500-1:1000, Immunohistochemistry (Paraffin): 0.4-0.8 µg/mL, Western Blot: 0.5-1.0 µg/mL
Aliases :
DKFZp686N23123; ER; Er alpha; ER36; ERa; ERALPHA; ER-alpha; ESR; esr 1; Esr1; esr-1; ESRA; Estr; Estra; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor; estrogen receptor 1; estrogen receptor 1 (alpha); estrogen receptor alpha; estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha splice variant, CTERP-1; estrogen receptor alpha splice variant, ERalphaDup5; estrogen receptor alpha splice variant, ERalphai45a; estrogen receptor alpha splice variant, ERalphai45bL; estrogen receptor alpha splice variant, ERalphai45bS; estrogen receptor alpha splice variant, ERalphai45c; estrogen receptor alpha splice variant, ERalphai56; estrogen receptor alpha splice variant, ERalphai67; estrogen receptor alpha variant delta 4; estrogen receptor alpha-like; estrogen receptor protein; estrogen receptor, alpha; ESTRR; hER-alpha36; I79_001166; LOC100351261; Nr3a1; nuclear receptor; Nuclear receptor subfamily 3 group A member 1; RNESTROR; RP1-130E4.1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA