This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
MUC1 Monoclonal Antibody (GP1.4)
catalog :
MA5-13168
quantity :
500µL
price :
US 305
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
GP1.4
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 14
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 1f
Kato K, Uchino R, Lillehoj E, Knox K, Lin Y, Kim K. Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages. Am J Respir Cell Mol Biol. 2016;54:515-23 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 5
  • flow cytometry; human; fig 1
  • western blot; human; fig 1
Li Q, Liu G, Yuan H, Wang J, Guo Y, Chen T, et al. Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21(WAF1) pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells. Oncotarget. 2015;6:4253-65 pubmed
  • immunohistochemistry; human; 1:400
BaÅŸak K, KiroÄŸlu K. Multiple oncocytic cystadenoma with intraluminal crystalloids in parotid gland: case report. Medicine (Baltimore). 2014;93:e246 pubmed publisher
  • immunohistochemistry - paraffin section; human
Abdelzaher E, Abdallah D. Expression of mesothelioma-related markers in meningiomas: an immunohistochemical study. Biomed Res Int. 2014;2014:968794 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse; 1:2000
Wang F, Li Q, Ni W, Fang F, Sun X, Xie F, et al. Expression of human full-length MUC1 inhibits the proliferation and migration of a B16 mouse melanoma cell line. Oncol Rep. 2013;30:260-8 pubmed publisher
  • immunohistochemistry; human; 1:500
Lau P, Lui P, Lau G, Yau D, Cheung E, Chan J. EWSR1-CREB3L1 gene fusion: a novel alternative molecular aberration of low-grade fibromyxoid sarcoma. Am J Surg Pathol. 2013;37:734-8 pubmed publisher
  • immunohistochemistry; human; 1:500
Lau P, Yau D, Lau W, Mak L, Chan J. Multinodular reticular schwannoma in the head and neck region: a potential diagnostic pitfall. Int J Surg Pathol. 2013;21:54-8 pubmed publisher
  • immunocytochemistry; human
Hisatsune A, Nakayama H, Kawasaki M, Horie I, Miyata T, Isohama Y, et al. Anti-MUC1 antibody inhibits EGF receptor signaling in cancer cells. Biochem Biophys Res Commun. 2011;405:377-81 pubmed publisher
  • immunohistochemistry; human
Metallo C, Azarin S, Moses L, Ji L, de Pablo J, Palecek S. Human embryonic stem cell-derived keratinocytes exhibit an epidermal transcription program and undergo epithelial morphogenesis in engineered tissue constructs. Tissue Eng Part A. 2010;16:213-23 pubmed publisher
  • immunohistochemistry; human; 1:100
Kelten C, Kabukcu S, Sen N, Teke Z, Yaren A, Erdem E, et al. Secondary involvement of the breast in T-cell non-Hodgkin lymphoma, an unusual example mimicking inflammatory breast carcinoma. Arch Gynecol Obstet. 2009;280:149-52 pubmed publisher
  • immunohistochemistry; human
Vardar E, Gunlusoy B, Arslan M, Kececi S. Myointimoma of the glans penis. Pathol Int. 2007;57:158-61 pubmed
  • immunohistochemistry; human; 1:1000
Yilmazbayhan D, Ates L, Dilege S, Gulluoglu M, Tanju S, Kalayci G. Pulmonary large cell carcinoma with rhabdoid phenotype. Ann Diagn Pathol. 2005;9:223-6 pubmed
Gruber H, Ingram J, Hoelscher G, Marrero E, Hanley E. Mucin 1, a signal transduction membrane-bound mucin, is present in human disc tissue and is downregulated in vitro by exposure to IL-1ß or TNF-α. BMC Musculoskelet Disord. 2017;18:182 pubmed publisher
Stanley C, Phillips T. Selective secretion and replenishment of discrete mucin glycoforms from intestinal goblet cells. Am J Physiol. 1999;277:G191-200 pubmed publisher
product information
Product Type :
Antibody
Product Name :
MUC1 Monoclonal Antibody (GP1.4)
Catalog # :
MA5-13168
Quantity :
500µL
Price :
US 305
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Flow Cytometry: 1-2 µg/test, Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunohistochemistry (Paraffin): 0.1-0.2 µg/mL
Species :
Human, Mouse
Clone :
GP1.4
Isotype :
IgG1
Storage :
4° C
Description :
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM and EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. MUC1 is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis, and sequential addition and processing of numerous O-linked glycans that are heavily sialylated. MUC1 is highly polymorphic and each allele encodes a product that contains a different number of repeats (between 30 and 90) leading to large differences in molecular weight of the protein. MUC1 is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells, and is expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. Overexpression, aberrant intracellular localization, and changes in glycosylation of the MUC1 protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of the MUC1 gene have been reported, but the full-length nature of only some has been determined. Transgenic MUC-1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
Immunogen :
Human milk fat globule membranes
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1-2 µg/test, Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunohistochemistry (Paraffin): 0.1-0.2 µg/mL
Aliases :
Epithelial Membrane Antigen, EMA, CD227, Episialin, CD227, EMA, H23AG, KL-6, MAM6, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, DF3 antigen, H23 antigen, breast carcinoma-associated antigen DF3
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA