Cytokeratin Pan Type I Monoclonal Antibody (AE1) | Invitrogen MA5-13144 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cytokeratin Pan Type I Monoclonal Antibody (AE1)

catalog :

MA5-13144

quantity :

500 µL

price :

US 341

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AE1

reactivity :

human, mouse, rat, chicken, bovine, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:100; fig s6	Zheng L, Cardaci S, Jerby L, MacKenzie E, Sciacovelli M, Johnson T, et al. Fumarate induces redox-dependent senescence by modifying glutathione metabolism. Nat Commun. 2015;6:6001 pubmed publisher
immunohistochemistry; human; ready-to-use	BaÅŸak K, KiroÄŸlu K. Multiple oncocytic cystadenoma with intraluminal crystalloids in parotid gland: case report. Medicine (Baltimore). 2014;93:e246 pubmed publisher
immunohistochemistry; human; 1:200	Xu S, Jiang J, Yu X, Sheng D, Zhu T, Jin M. Association of Merkel cell polyomavirus infection with EGFR mutation status in Chinese non-small cell lung cancer patients. Lung Cancer. 2014;83:341-6 pubmed publisher
immunohistochemistry; human; 1:100	Lin J, Lu C, Lin W, Wu Y, Huang Y, Shih F, et al. A clinicopathological study of the significance of the proportion of choroid morphology in chordoid meningioma. J Clin Neurosci. 2012;19:836-43 pubmed publisher
immunohistochemistry; human; 1:100	Lin J, Wu Y, Chang I. The prognostic impact of O6-methylguanine DNA methyltransferase and epidermal growth factor receptor expressions on primary gliosarcoma: a clinicopathologic and immunohistochemical study of seven cases at a single institution. Indian J Pathol Microbiol. 2011;54:683-7 pubmed publisher
immunohistochemistry; human; 1:100	Wu Y, Ho J, Lin Y, Lin J. Rhabdoid papillary meningioma: a clinicopathologic case series study. Neuropathology. 2011;31:599-605 pubmed publisher
immunohistochemistry; human; 1:100	Chen H, Wu Y, Lin Y, Lin J. Clear cell meningioma with frequent chordoid features and aggressive behavior: a clinicopathologic study of ten cases at a single institution. J Neurooncol. 2011;103:551-9 pubmed publisher
immunohistochemistry; human; 1:50	Balic M, Rapp N, Stanzer S, Lin H, Strutz J, Szkandera J, et al. Novel immunofluorescence protocol for multimarker assessment of putative disseminating breast cancer stem cells. Appl Immunohistochem Mol Morphol. 2011;19:33-40 pubmed publisher
immunohistochemistry; human; 1:100	Lin J, Ho J, Lin Y, Wu Y. Chordoid meningioma: a clinicopathologic study of 11 cases at a single institution. J Neurooncol. 2010;100:465-73 pubmed publisher
immunohistochemistry; human; 1:100	Chang I, Huang H, Sung M. Melanotic Xp11 translocation renal cancer: a case with PSF-TFE3 gene fusion and up-regulation of melanogenetic transcripts. Am J Surg Pathol. 2009;33:1894-901 pubmed publisher
western blot; human; 1:1000	Chang C, Chiou P, Chen W, Li Y, Yiu J, Cheng Y, et al. Assessment of the tumorigenesis and drug susceptibility of three new canine mammary tumor cell lines. Res Vet Sci. 2010;88:285-93 pubmed publisher
immunohistochemistry - paraffin section; human; 1:300; tbl 2	Gil da Costa R, Santos M, Amorim I, Lopes C, Pereira P, Faustino A. An immunohistochemical study of feline endometrial adenocarcinoma. J Comp Pathol. 2009;140:254-9 pubmed publisher
immunohistochemistry; rat; 1:100	Esendagli G, Yilmaz G, Canpinar H, Gunel Ozcan A, Guc M, Guc D. Coexistence of different tissue tumourigenesis in an N-methyl-N-nitrosourea-induced mammary carcinoma model: a histopathological report in Sprague-Dawley rats. Lab Anim. 2009;43:60-4 pubmed publisher
immunohistochemistry; human	Yagci G, Unlu A, Kurt B, Can M, Kaymakcioglu N, Cetiner S, et al. Detection of micrometastases and skip metastases with ex vivo sentinel node mapping in carcinoma of the colon and rectum. Int J Colorectal Dis. 2007;22:167-73 pubmed
immunohistochemistry; human	Atinkaya C, Ozlem Küçük N, Koparal H, Aras G, Sak S, Ozdemir N. Mediastinal intraoperative radioisotope sentinel lymph node mapping in non-small-cell lung cancer. Nucl Med Commun. 2005;26:717-20 pubmed
	Favia G, Kanduc D, Lo Muzio L, Lucchese A, Serpico R. Possible association between HPV16 E7 protein level and cytokeratin 19. Int J Cancer. 2004;111:795-7 pubmed
	Ihtiyar E, Isiksoy S, Algin C, Sahin A, Erkasap S, Yasar B. Ectopic thyroid in the gallbladder: report of a case. Surg Today. 2003;33:777-80 pubmed

image

image 1 :

Formalin-fixed, paraffin-embedded human squamous cell carcinoma of lung stained with Keratin, LMW antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.

product information

Product Type :

Antibody

Product Name :

Cytokeratin Pan Type I Monoclonal Antibody (AE1)

Catalog # :

MA5-13144

Quantity :

500 µL

Price :

US 341

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine, Chicken, Human, Mouse, Non-human primate, Rabbit, Rat

Applications :

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1:2,000

Species :

Bovine, Chicken, Human, Mouse, Non-human primate, Rabbit, Rat

Clone :

AE1

Isotype :

IgG1

Storage :

4° C

Description :

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

Immunogen :

Human epidermal keratin

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1:2,000

Aliases :

40-kDa keratin intermediate filament; 56 kDa cytokeratin; 67 kDa cytokeratin; AA960620; AI324768; AI528832; AI626930; AI663979; AL022697; alpha keratin; AU019895; BCIE; BIE; Card2; Cell proliferation-inducing gene 46 protein; CK1; CK-1; CK10; CK-10; CK14; CK-14; CK15; CK-15; CK16; CK-16; CK18; CK-18; CK19; CK-19; CK8; CK-8; CK-9; CYK18; CYK8; CYKER; cytokeratin 1; cytokeratin 10; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 8; cytokeratin 8 (370 AA); cytokeratin 9; cytokeratin endo A; Cytokeratin endo B; cytokeratin VIB; cytokeratin VII; Cytokeratin-1; Cytokeratin-10; cytokeratin-14; Cytokeratin-15; cytokeratin-16; Cytokeratin-18; cytokeratin-19; Cytokeratin-6B; cytokeratin-7; cytokeratin-8; Cytokeratin-9; cytokeratin-A; D130054E02Rik; EBS3; EBS4; EGK_03685; EHK; EHK1; Endo B; EndoA; EndoC; epidermal keratin 10; epidermal keratin VII; epidermolysis bullosa simplex, Dowling-Meara, Koebner; epidermolytic hyperkeratosis 1; epidermolytic hyperkeratosis; keratosis palmaris et plantaris; epithelial keratin 1; epithelial keratin 10; Epithelial keratin-1; EPPK; FNEPPK; focal non-epidermolytic palmoplantar keratoderma; GK-19; Hair alpha protein; HMWCK; intermediate filament protein; K1; K10; K14; K15; K16; K18; K19; K1C1; K1CO; K1CP; K1CS; K2C8; K8; K9; Ka10; Ka14; Ka15; Ka16; Ka19; Kb1; KER1; Ker10; KERA; keratin 1; keratin 1 (epidermolytic hyperkeratosis); keratin 1, type II; keratin 10; keratin 10 (epidermolytic hyperkeratosis); keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris); keratin 10, type I; keratin 13; keratin 14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 15; keratin 15, type I; keratin 16; keratin 16 (focal non-epidermolytic palmoplantar keratoderma); keratin 16, type I; keratin 18; keratin 18, type I; keratin 19; keratin 19, type I; keratin 24; keratin 8; keratin 8, type II; keratin 86; keratin 9; keratin 9 (epidermolytic palmoplantar keratoderma); keratin 9, type I; keratin complex 1, acidic, gene 10; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 15; keratin complex 1, acidic, gene 16; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; keratin complex 1, acidic, gene 9; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 8; keratin D; keratin intermediate filament 16a; keratin intermediate filament 16b; keratin, type I cytoskeletal 10; keratin, type I cytoskeletal 10-like; keratin, type I cytoskeletal 13; keratin, type I cytoskeletal 14; keratin, type I cytoskeletal 14; keratin, type I cytoskeletal 16; keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; keratin, type I cytoskeletal 59 kDa; Keratin, type I cytoskeletal 9; keratin, type I, 40-kd; keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 8; keratin-1; Keratin-10; keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; keratin-16; Keratin-18; keratin-19; Keratin-8; keratin-9; Kerd; KO; KPP; KRT1; krt1 {ECO:0000250; Krt-1.10; Krt-1.14; Krt-1.19; KRT10; krt10 {ECO:0000250; Krt1-10; Krt1-14; Krt1-15; Krt1-16; Krt1-18; Krt1-19; KRT13; KRT14; Krt15; krt15 {ECO:0000250; Krt16; KRT16A; KRT18; krt18 {ECO:0000250; KRT19; Krt1-9; KRT1A; Krt-2.1; Krt-2.8; Krt2-1; KRT24; Krt2-8; Krt8; Krt86; krt9; KRTA; KRTB; LOW QUALITY PROTEIN: keratin, type I cytoskeletal 15; NEPPK; NFJ; pan keratin; pankeratin; PC1; PIG46; Spermatid perinuclear ring manchette protein K9; suprabasal cytokeratin 10; type I alpha-keratin 14; type I alpha-keratin 15; type I cytoskeletal 15; type I cytoskeletal 9; type I keratin KA10; Type I keratin Ka14; type I keratin KA15; type I keratin KA16; Type I keratin Ka19; type II cytokeratin A (no.8); type II keratin Kb1; type-II keratin Kb1; Type-II keratin Kb8; UniProtKB:P04264}; UniProtKB:P05783}; UniProtKB:P13645}; UniProtKB:P19012}; unnamed protein product

more info or order :

Invitrogen product webpage