Cyclin B1 Monoclonal Antibody (V152) | Invitrogen MA5-13128 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cyclin B1 Monoclonal Antibody (V152)

catalog :

MA5-13128

quantity :

500 µL

price :

US 496

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

V152

reactivity :

Chinese hamsters, human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 18

Reference
Bona A, Calcagno D, Ribeiro H, Muniz J, Pinto G, Rocha C, et al. Menadione reduces CDC25B expression and promotes tumor shrinkage in gastric cancer. Therap Adv Gastroenterol. 2020;13:1756284819895435 pubmed publisher
Ganesh S, Horvat F, Drutovic D, Efenberková M, Pinkas D, Jindrova A, et al. The most abundant maternal lncRNA Sirena1 acts post-transcriptionally and impacts mitochondrial distribution. Nucleic Acids Res. 2020;48:3211-3227 pubmed publisher
Kruiswijk F, Hasenfuss S, Sivapatham R, Baar M, Putavet D, Naipal K, et al. Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling. Oncogene. 2016;35:2166-77 pubmed publisher
Komrskova P, Susor A, Malik R, Procházková B, Liskova L, Supolikova J, et al. Aurora kinase A is not involved in CPEB1 phosphorylation and cyclin B1 mRNA polyadenylation during meiotic maturation of porcine oocytes. PLoS ONE. 2014;9:e101222 pubmed publisher
Woo G, Takahashi M, Inoue K, Fujimoto H, Igarashi K, Kanno J, et al. Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model. Cancer Sci. 2009;100:617-25 pubmed publisher
Whittaker S, te Poele R, Chan F, Linardopoulos S, Walton M, Garrett M, et al. The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis. Cell Cycle. 2007;6:3114-31 pubmed
Ersvaer E, Zhang J, McCormack E, Olsnes A, Anensen N, Tan E, et al. Cyclin B1 is commonly expressed in the cytoplasm of primary human acute myelogenous leukemia cells and serves as a leukemia-associated antigen associated with autoantibody response in a subset of patients. Eur J Haematol. 2007;79:210-25 pubmed
Hall J, Kow E, Nevis K, Lu C, Luce K, Zhong Q, et al. Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. Mol Biol Cell. 2007;18:3340-50 pubmed
Zhang J, Eguchi J, Kruse C, Gomez G, Fakhrai H, Schroter S, et al. Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. Clin Cancer Res. 2007;13:566-575 pubmed publisher
Davy C, Ayub M, Jackson D, Das P, McIntosh P, Doorbar J. HPV16 E1--E4 protein is phosphorylated by Cdk2/cyclin A and relocalizes this complex to the cytoplasm. Virology. 2006;349:230-44 pubmed publisher
Nakamura N, Yamamoto H, Yao T, Oda Y, Nishiyama K, Imamura M, et al. Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk grade. Hum Pathol. 2005;36:828-37 pubmed
Raynaud F, Whittaker S, Fischer P, McClue S, Walton M, Barrie S, et al. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clin Cancer Res. 2005;11:4875-87 pubmed
Petermann A, Pippin J, Hiromura K, Monkawa T, Durvasula R, Couser W, et al. Mitotic cell cycle proteins increase in podocytes despite lack of proliferation. Kidney Int. 2003;63:113-22 pubmed
Liu H, Di Cunto F, Imarisio S, Reid L. Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes. J Biol Chem. 2003;278:2541-8 pubmed
Carow C, Fox N, Kaushansky K. Kinetics of endomitosis in primary murine megakaryocytes. J Cell Physiol. 2001;188:291-303 pubmed
Leoncini L, Lazzi S, Scano D, Mura A, Onida A, Massarelli G, et al. Expression of the ALK protein by anaplastic large-cell lymphomas correlates with high proliferative activity. Int J Cancer. 2000;86:777-81 pubmed
Leoncini L, Bellan C, Cossu A, Claudio P, Lazzi S, Cinti C, et al. Retinoblastoma-related p107 and pRb2/p130 proteins in malignant lymphomas: distinct mechanisms of cell growth control. Clin Cancer Res. 1999;5:4065-72 pubmed
Leoncini L, Cossu A, Megha T, Bellan C, Lazzi S, Luzi P, et al. Expression of p34(cdc2) and cyclins A and B compared to other proliferative features of non-Hodgkin's lymphomas: a multivariate cluster analysis. Int J Cancer. 1999;83:203-9 pubmed

product information

Product Type :

Antibody

Product Name :

Cyclin B1 Monoclonal Antibody (V152)

Catalog # :

MA5-13128

Quantity :

500 µL

Price :

US 496

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Hamster, Human, Mouse

Applications :

Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1-3 µg/mL

Species :

Hamster, Human, Mouse

Clone :

V152

Isotype :

IgG1

Storage :

4° C

Description :

Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs). Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis. It is essential for the control of the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis. Destruction of Cyclin B1 is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.

Immunogen :

Hamster cyclin B1 protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1-3 µg/mL

Aliases :

Ccn-2; CCNB; Ccnb1; Ccnb1-rs1; Ccnb1-rs13; Cycb; CycB1; Cycb1-rs1; Cycb-4; Cycb-5; cyclin B; cyclin B1; cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; I79_013589; OTTHUMP00000221981; OTTHUMP00000223023