CD35 Monoclonal Antibody (E11) | Invitrogen MA5-13122 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD35 Monoclonal Antibody (E11)

catalog :

MA5-13122

quantity :

500 µL

price :

US 464

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

E11

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 1k	Bell L, Lenhart A, Rosenwald A, Monoranu C, Berberich Siebelt F. Lymphoid Aggregates in the CNS of Progressive Multiple Sclerosis Patients Lack Regulatory T Cells. Front Immunol. 2019;10:3090 pubmed publisher
immunohistochemistry; human; 1:100	Tasca S, Zhuang K, Gettie A, Knight H, Blanchard J, Westmoreland S, et al. Effect of B-cell depletion on coreceptor switching in R5 simian-human immunodeficiency virus infection of rhesus macaques. J Virol. 2011;85:3086-94 pubmed publisher
	Riba M, Campo Sabariz J, Tena I, Molina Porcel L, Ximelis T, Calvo M, et al. Wasteosomes (corpora amylacea) of human brain can be phagocytosed and digested by macrophages. Cell Biosci. 2022;12:177 pubmed publisher
	Harada Y, Kato Y, Miyaji T, Omote H, Moriyama Y, Hiasa M. Vesicular nucleotide transporter mediates ATP release and migration in neutrophils. J Biol Chem. 2018;293:3770-3779 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD35 Monoclonal Antibody (E11)

Catalog # :

MA5-13122

Quantity :

500 µL

Price :

US 464

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1 µg/test, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:50-1:100

Species :

Human

Clone :

E11

Isotype :

IgG1

Storage :

4° C

Description :

CD35 (CR1, Complement Receptor 1) is a cell membrane-bound, monomeric glycoprotein and its primary function is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. CD35 protein mediates cellular binding to particles and immune complexes that have activated complement. The CD35 complex is four different allotypes (C,A,B,D) C is 160 kDa; A is 190 kDa; B is 220 kDa and D is 250 kDa. CD35 is involved in the processing of immune complexes, promoting of binding and phagocytosis of C3b complexes and inhibition of complement activation. CD35 is on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, follicular dendritic reticulum cells and is negative on basophils. Decreases in expression of CD35 protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in the CD35 gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants encoding different isoforms of CD35 have been characterized. An additional secreted form of CD35 have also been described but has not been fully characterized.

Immunogen :

Intact human monocytes

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:50-1:100

Aliases :

C3 binding protein; C3b/C4b receptor; C3-binding protein; C3BR; C4BR; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); Complement Component (3b/4b) receptor 1 including Knops blood group system; complement component 3b/4b receptor 1 (Knops blood group); complement receptor type 1; CR1; KN; Knops blood group antigen