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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Chromogranin A Monoclonal Antibody (LK2H10)
catalog :
MA5-13096
quantity :
500 uL
price :
US 434.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
LK2H10
reactivity :
guinea pig, human, rat, pigs , domestic rabbit
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 45
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; fig 7a
Chang Y, Lin T, Campbell M, Pan C, Lee S, Lee H, et al. REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer. Sci Rep. 2017;7:42795 pubmed publisher
  • western blot; human; loading ...; fig 1c
Maina P, Shao P, Liu Q, Fazli L, Tyler S, Nasir M, et al. c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer. Oncotarget. 2016;7:75585-75602 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; fig 2
Edfeldt K, Hellman P, Westin G, Stalberg P. A plausible role for actin gamma smooth muscle 2 (ACTG2) in small intestinal neuroendocrine tumorigenesis. BMC Endocr Disord. 2016;16:19 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:800; fig 5
Sei Y, Feng J, Zhao X, Forbes J, Tang D, Nagashima K, et al. Polyclonal Crypt Genesis and Development of Familial Small Intestinal Neuroendocrine Tumors. Gastroenterology. 2016;151:140-51 pubmed publisher
  • immunohistochemistry; human; 1:150; fig 1
Korsgren E, Korsgren O. An Apparent Deficiency of Lymphatic Capillaries in the Islets of Langerhans in the Human Pancreas. Diabetes. 2016;65:1004-8 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
Lu J, Adam B, Jack A, Lam A, Broad R, Chik C. Immune Cell Infiltrates in Pituitary Adenomas: More Macrophages in Larger Adenomas and More T Cells in Growth Hormone Adenomas. Endocr Pathol. 2015;26:263-72 pubmed publisher
  • immunohistochemistry - paraffin section; guinea pig; 1:800
Hussein O, Elgamal D, Elgayar S. Structure of the secretory cells of male and female adult guinea pigs Harderian gland. Tissue Cell. 2015;47:323-35 pubmed publisher
  • immunohistochemistry; human; 1:800
Berruti A, Fazio N, Ferrero A, Brizzi M, Volante M, Nobili E, et al. Bevacizumab plus octreotide and metronomic capecitabine in patients with metastatic well-to-moderately differentiated neuroendocrine tumors: the XELBEVOCT study. BMC Cancer. 2014;14:184 pubmed publisher
  • immunohistochemistry; human; 1:800
Rapa I, Volante M, Migliore C, Farsetti A, Berruti A, Vittorio Scagliotti G, et al. Human ASH-1 promotes neuroendocrine differentiation in androgen deprivation conditions and interferes with androgen responsiveness in prostate cancer cells. Prostate. 2013;73:1241-9 pubmed publisher
  • immunohistochemistry; human; 1:4000
Hanna J, Reimann J, Haddad R, Krane J. Human papillomavirus-associated adenocarcinoma of the base of the tongue. Hum Pathol. 2013;44:1516-23 pubmed publisher
  • immunohistochemistry; human; 1:800
Volante M, Daniele L, Asioli S, Cassoni P, Comino A, Coverlizza S, et al. Tumor staging but not grading is associated with adverse clinical outcome in neuroendocrine tumors of the appendix: a retrospective clinical pathologic analysis of 138 cases. Am J Surg Pathol. 2013;37:606-12 pubmed publisher
  • immunohistochemistry; human; 1:800
Gündoğan M, Calli Demirkan N, Tekin K, Aybek H. Gastric histopathological findings and ghrelin expression in morbid obesity. Turk Patoloji Derg. 2013;29:19-26 pubmed publisher
  • immunohistochemistry; human; 1:800
Righi L, Rapa I, Votta A, Papotti M, Sapino A. Human achaete-scute homolog-1 expression in neuroendocrine breast carcinoma. Virchows Arch. 2012;460:415-21 pubmed publisher
  • immunohistochemistry; human; 1:4000
Kraft S, Faquin W, Krane J. HPV-associated neuroendocrine carcinoma of the oropharynx: a rare new entity with potentially aggressive clinical behavior. Am J Surg Pathol. 2012;36:321-30 pubmed publisher
  • immunohistochemistry; human; 1:100
Agarwal S, Sharma M, Sarkar C, Suri V, Jain A, Sharma M, et al. Extraventricular neurocytomas: a morphological and histogenetic consideration. A study of six cases. Pathology. 2011;43:327-34 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 1
Yong Jiang -, Huawei Liu -, Hu Long -, Yingying Yang -, Dianying Liao -, Xiuhui Zhang -. Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. Int J Surg Pathol. 2010;18:488-92 pubmed publisher
  • immunohistochemistry; human
Park S, Park C, Kim S, Jang S, Chi H, Kim M, et al. Detection of bone marrow metastases of neuroblastoma with immunohistochemical staining of CD56, chromogranin A, and synaptophysin. Appl Immunohistochem Mol Morphol. 2010;18:348-52 pubmed publisher
  • immunohistochemistry; human; 1:2000
Inzani F, Rindi G, Tamborrino E, Cobelli R, Bordi C. Extra-adrenal composite paraganglioma with ganglioneuroma component presenting as a pancreatic mass. Endocr Pathol. 2009;20:191-5 pubmed publisher
  • immunohistochemistry; human; 1:300
Mukhopadhyay S, El Zammar O, Katzenstein A. Pulmonary meningothelial-like nodules: new insights into a common but poorly understood entity. Am J Surg Pathol. 2009;33:487-95 pubmed publisher
  • western blot; human
Schrott Fischer A, Bitsche M, Humpel C, Walcher C, Maier H, Jellinger K, et al. Chromogranin peptides in amyotrophic lateral sclerosis. Regul Pept. 2009;152:13-21 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Han L, Suda M, Tsuzuki K, Wang R, Ohe Y, Hirai H, et al. A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells. Mol Endocrinol. 2008;22:1935-49 pubmed publisher
  • immunohistochemistry; human; 1:1000
Yaren A, Kelten C, Akbulut M, Teke Z, Duzcan E, Erdem E. Primary neuroendocrine carcinoma of the breast: a case report. Tumori. 2007;93:496-8 pubmed
  • immunohistochemistry; human; 1:1000
Marci V, Volante M, Cappia S, Righi L, Novello C, Scagliotti G, et al. Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma. Virchows Arch. 2007;451:729-36 pubmed
  • immunohistochemistry; human
Dilbaz B, Bayoglu Y, Oral S, Cavusoglu D, Uluoglu O, Dilbaz S. Laparoscopic resection of urinary bladder paraganglioma: a case report. Surg Laparosc Endosc Percutan Tech. 2006;16:58-61 pubmed
  • immunohistochemistry; human; 1:100
Yilmazbayhan D, Ates L, Dilege S, Gulluoglu M, Tanju S, Kalayci G. Pulmonary large cell carcinoma with rhabdoid phenotype. Ann Diagn Pathol. 2005;9:223-6 pubmed
  • western blot; human; 1:300
Filleur S, Volz K, Nelius T, Mirochnik Y, Huang H, Zaichuk T, et al. Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer. Cancer Res. 2005;65:5144-52 pubmed
  • immunohistochemistry; human; 1:50
Erdogan G, Ozel E, Pestereli H, Salar Z, Tirak B, Karaveli S. Ovarian ependymoma. APMIS. 2005;113:301-3 pubmed
Saini S, Sreekumar A, Nathani S, Asante D, Simmons M. A novel exosome based therapeutic intervention against neuroendocrine prostate cancer. Sci Rep. 2024;14:2816 pubmed publisher
Chang C, Cheng T, Yeh W, Luo Y, Campbell M, Kuo T, et al. REST-repressed lncRNA LINC01801 induces neuroendocrine differentiation in prostate cancer via transcriptional activation of autophagy. Am J Cancer Res. 2023;13:3983-4002 pubmed
Georgakopoulou V, Zygouris E, Papalexis P, Gkoufa A, Damaskos C, Pierrakou A, et al. Simultaneous pathological findings in biopsy specimens of patients with surgically resected lung carcinoids and their role in survival. Oncol Lett. 2022;24:313 pubmed publisher
Tran C, Borbon L, Mudd J, Abusada E, AghaAmiri S, Ghosh S, et al. Establishment of Novel Neuroendocrine Carcinoma Patient-Derived Xenograft Models for Receptor Peptide-Targeted Therapy. Cancers (Basel). 2022;14: pubmed publisher
Beumer J, Puschhof J, Yengej F, Zhao L, Martínez Silgado A, Blotenburg M, et al. BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states. Cell Rep. 2022;38:110438 pubmed publisher
Ear P, Li G, Wu M, Abusada E, Bellizzi A, Howe J. Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids. J Vis Exp. 2019;: pubmed publisher
Wang G, Lou H, Salit J, Leopold P, Driscoll S, Schymeinsky J, et al. Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity. Respir Res. 2019;20:196 pubmed publisher
Barazeghi E, Prabhawa S, Norlén O, Hellman P, Stalberg P, Westin G. Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors. BMC Cancer. 2018;18:764 pubmed publisher
Taurozzi A, Beekharry R, Wantoch M, Labarthe M, Walker H, Seed R, et al. Spontaneous development of Epstein-Barr Virus associated human lymphomas in a prostate cancer xenograft program. PLoS ONE. 2017;12:e0188228 pubmed publisher
Noble A, Maitland N, Berney D, Rumsby M. Phospholipase D inhibitors reduce human prostate cancer cell proliferation and colony formation. Br J Cancer. 2017;: pubmed publisher
Haberal H, Tonyali S, Baydar D, Bilen C. Acute renal failure due to small cell neuroendocrine carcinoma of the left kidney: A case report. Oncol Lett. 2017;14:6117-6120 pubmed publisher
Pages M, Lacroix L, Tauziède Espariat A, Castel D, Daudigeos Dubus E, Ridola V, et al. Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion. Acta Neuropathol Commun. 2015;3:85 pubmed publisher
Hedborg F, Fischer Colbrie R, Ostlin N, Sandstedt B, Tran M, Maxwell P. Differentiation in neuroblastoma: diffusion-limited hypoxia induces neuro-endocrine secretory protein 55 and other markers of a chromaffin phenotype. PLoS ONE. 2010;5: pubmed publisher
Barbareschi M, Roldo C, Zamboni G, Capelli P, Cavazza A, Macri E, et al. CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors. Am J Surg Pathol. 2004;28:1169-76 pubmed
Deveci M, Deveci G. Altered distribution of metaplastic Paneth, gastrin and pancreatic acinar cells in atrophic gastritic mucosa with endocrine cell lesions. Tohoku J Exp Med. 2004;202:13-22 pubmed
Papi G, Corrado S, Pomponi M, Carapezzi C, Cesinaro A, LiVolsi V. Concurrent lymph node metastases of medullary and papillary thyroid carcinoma in a case with RET oncogene germline mutation. Endocr Pathol. 2003;14:269-76 pubmed
van Eeden S, Quaedvlieg P, Taal B, Offerhaus G, Lamers C, van Velthuysen M. Classification of low-grade neuroendocrine tumors of midgut and unknown origin. Hum Pathol. 2002;33:1126-32 pubmed
Adam R, Kim J, Lin J, Orsola A, Zhuang L, Rice D, et al. Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function. Endocrinology. 2002;143:4599-608 pubmed
product information
Product Type :
Antibody
Product Name :
Chromogranin A Monoclonal Antibody (LK2H10)
Catalog # :
MA5-13096
Quantity :
500 uL
Price :
US 434.00
Clonality :
Monoclonal
Purity :
Protein A/G
Host :
Mouse
Reactivity :
Human, Non-human primate, Porcine, Rabbit, Rat
Applications :
Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:800, Western Blot: 1-2 ug/mL
Species :
Human, Non-human primate, Porcine, Rabbit, Rat
Clone :
LK2H10
Isotype :
IgG1, kappa
Storage :
4 C
Description :
Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
Immunogen :
Human pheochromocytoma
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:800, Western Blot: 1-2 ug/mL
Aliases :
AL-11; AL26; Beta-granin; betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; CHGA; ChrA; chromofungin; chromogranin A; chromogranin A (parathyroid secretory protein 1); chromogranin A precursor; chromogranin-A; CTNNB; DKFZp686D02253; EA-92; ER-37; ES-43; FLJ25606; FLJ37923; GE-25; GR-44; GV-19; LF-19; LOW QUALITY PROTEIN: chromogranin-A; MGC105435; Pancreastatin; Parastatin; parathyroid secretory protein 1; p-Glu serpinin precursor; pituitary secretory protein I; Serpinin; Serpinin-RRG; SL21; SP-I; SS-18; Vasostatin I; Vasostatin II; Vasostatin-1; Vasostatin-2; WA-8; WE-14
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA