Chromogranin A Monoclonal Antibody (LK2H10), Biotin | Invitrogen MA5-13093 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Chromogranin A Monoclonal Antibody (LK2H10), Biotin

catalog :

MA5-13093

quantity :

500 µL

price :

US 410.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

LK2H10

reactivity :

human, rat, pigs , domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 27

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:800	Berruti A, Fazio N, Ferrero A, Brizzi M, Volante M, Nobili E, et al. Bevacizumab plus octreotide and metronomic capecitabine in patients with metastatic well-to-moderately differentiated neuroendocrine tumors: the XELBEVOCT study. BMC Cancer. 2014;14:184 pubmed publisher
immunohistochemistry; human; 1:800	Rapa I, Volante M, Migliore C, Farsetti A, Berruti A, Vittorio Scagliotti G, et al. Human ASH-1 promotes neuroendocrine differentiation in androgen deprivation conditions and interferes with androgen responsiveness in prostate cancer cells. Prostate. 2013;73:1241-9 pubmed publisher
immunohistochemistry; human; 1:4000	Hanna J, Reimann J, Haddad R, Krane J. Human papillomavirus-associated adenocarcinoma of the base of the tongue. Hum Pathol. 2013;44:1516-23 pubmed publisher
immunohistochemistry; human; 1:800	Volante M, Daniele L, Asioli S, Cassoni P, Comino A, Coverlizza S, et al. Tumor staging but not grading is associated with adverse clinical outcome in neuroendocrine tumors of the appendix: a retrospective clinical pathologic analysis of 138 cases. Am J Surg Pathol. 2013;37:606-12 pubmed publisher
immunohistochemistry; human; 1:800	Gündoğan M, Calli Demirkan N, Tekin K, Aybek H. Gastric histopathological findings and ghrelin expression in morbid obesity. Turk Patoloji Derg. 2013;29:19-26 pubmed publisher
immunocytochemistry; human immunohistochemistry; human	Cortés M, Cariaga Martínez A, Lobo M, Martín Orozco R, Motiño O, Rodríguez Ubreva F, et al. EGF promotes neuroendocrine-like differentiation of prostate cancer cells in the presence of LY294002 through increased ErbB2 expression independent of the phosphatidylinositol 3-kinase-AKT pathway. Carcinogenesis. 2012;33:1169-77 pubmed publisher
immunohistochemistry; human; 1:800	Righi L, Rapa I, Votta A, Papotti M, Sapino A. Human achaete-scute homolog-1 expression in neuroendocrine breast carcinoma. Virchows Arch. 2012;460:415-21 pubmed publisher
immunohistochemistry; human; 1:5000	Curradi G, Walters M, Ding B, Rafii S, Hackett N, Crystal R. Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells. Cell Mol Life Sci. 2012;69:2217-31 pubmed publisher
immunohistochemistry; human; 1:4000	Kraft S, Faquin W, Krane J. HPV-associated neuroendocrine carcinoma of the oropharynx: a rare new entity with potentially aggressive clinical behavior. Am J Surg Pathol. 2012;36:321-30 pubmed publisher
immunohistochemistry; human; 1:100	Agarwal S, Sharma M, Sarkar C, Suri V, Jain A, Sharma M, et al. Extraventricular neurocytomas: a morphological and histogenetic consideration. A study of six cases. Pathology. 2011;43:327-34 pubmed publisher
immunohistochemistry; human	Park S, Park C, Kim S, Jang S, Chi H, Kim M, et al. Detection of bone marrow metastases of neuroblastoma with immunohistochemical staining of CD56, chromogranin A, and synaptophysin. Appl Immunohistochem Mol Morphol. 2010;18:348-52 pubmed publisher
immunohistochemistry; human; 1:2000	Inzani F, Rindi G, Tamborrino E, Cobelli R, Bordi C. Extra-adrenal composite paraganglioma with ganglioneuroma component presenting as a pancreatic mass. Endocr Pathol. 2009;20:191-5 pubmed publisher
immunohistochemistry; human; 1:300	Mukhopadhyay S, El Zammar O, Katzenstein A. Pulmonary meningothelial-like nodules: new insights into a common but poorly understood entity. Am J Surg Pathol. 2009;33:487-95 pubmed publisher
western blot; human	Schrott Fischer A, Bitsche M, Humpel C, Walcher C, Maier H, Jellinger K, et al. Chromogranin peptides in amyotrophic lateral sclerosis. Regul Pept. 2009;152:13-21 pubmed publisher
immunocytochemistry; human western blot; human	Han L, Suda M, Tsuzuki K, Wang R, Ohe Y, Hirai H, et al. A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells. Mol Endocrinol. 2008;22:1935-49 pubmed publisher
immunohistochemistry; human; 1:1000	Yaren A, Kelten C, Akbulut M, Teke Z, Duzcan E, Erdem E. Primary neuroendocrine carcinoma of the breast: a case report. Tumori. 2007;93:496-8 pubmed
immunohistochemistry; human; 1:1000	Marci V, Volante M, Cappia S, Righi L, Novello C, Scagliotti G, et al. Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma. Virchows Arch. 2007;451:729-36 pubmed
immunohistochemistry; human	Dilbaz B, Bayoglu Y, Oral S, Cavusoglu D, Uluoglu O, Dilbaz S. Laparoscopic resection of urinary bladder paraganglioma: a case report. Surg Laparosc Endosc Percutan Tech. 2006;16:58-61 pubmed
immunohistochemistry; human; 1:100	Yilmazbayhan D, Ates L, Dilege S, Gulluoglu M, Tanju S, Kalayci G. Pulmonary large cell carcinoma with rhabdoid phenotype. Ann Diagn Pathol. 2005;9:223-6 pubmed
western blot; human; 1:300	Filleur S, Volz K, Nelius T, Mirochnik Y, Huang H, Zaichuk T, et al. Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer. Cancer Res. 2005;65:5144-52 pubmed
immunohistochemistry; human; 1:50	Erdogan G, Ozel E, Pestereli H, Salar Z, Tirak B, Karaveli S. Ovarian ependymoma. APMIS. 2005;113:301-3 pubmed
	Hedborg F, Fischer Colbrie R, Ostlin N, Sandstedt B, Tran M, Maxwell P. Differentiation in neuroblastoma: diffusion-limited hypoxia induces neuro-endocrine secretory protein 55 and other markers of a chromaffin phenotype. PLoS ONE. 2010;5: pubmed publisher
	Barbareschi M, Roldo C, Zamboni G, Capelli P, Cavazza A, Macri E, et al. CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors. Am J Surg Pathol. 2004;28:1169-76 pubmed
	Deveci M, Deveci G. Altered distribution of metaplastic Paneth, gastrin and pancreatic acinar cells in atrophic gastritic mucosa with endocrine cell lesions. Tohoku J Exp Med. 2004;202:13-22 pubmed
	Papi G, Corrado S, Pomponi M, Carapezzi C, Cesinaro A, LiVolsi V. Concurrent lymph node metastases of medullary and papillary thyroid carcinoma in a case with RET oncogene germline mutation. Endocr Pathol. 2003;14:269-76 pubmed
	van Eeden S, Quaedvlieg P, Taal B, Offerhaus G, Lamers C, van Velthuysen M. Classification of low-grade neuroendocrine tumors of midgut and unknown origin. Hum Pathol. 2002;33:1126-32 pubmed
	Adam R, Kim J, Lin J, Orsola A, Zhuang L, Rice D, et al. Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function. Endocrinology. 2002;143:4599-608 pubmed

image

image 1 :

image 2 :

Formalin-fixed, paraffin-embedded rat pancreas stained with Chromogranin A antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of islet cells.

image 3 :

product information

Product Type :

Antibody

Product Name :

Chromogranin A Monoclonal Antibody (LK2H10), Biotin

Catalog # :

MA5-13093

Quantity :

500 µL

Price :

US 410.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Non-human primate, Porcine, Rabbit, Rat

Applications :

Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:800, Western Blot: 1-2 µg/mL

Species :

Human, Non-human primate, Porcine, Rabbit, Rat

Clone :

LK2H10

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.

Immunogen :

Human pheochromocytoma

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:800, Western Blot: 1-2 µg/mL

Aliases :

AL-11; AL26; Beta-granin; betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; CHGA; ChrA; chromofungin; chromogranin A; chromogranin A (parathyroid secretory protein 1); chromogranin A precursor; chromogranin-A; CTNNB; DKFZp686D02253; EA-92; ER-37; ES-43; FLJ25606; FLJ37923; GE-25; GR-44; GV-19; LF-19; LOW QUALITY PROTEIN: chromogranin-A; MGC105435; Pancreastatin; Parastatin; parathyroid secretory protein 1; p-Glu serpinin precursor; pituitary secretory protein I; Serpinin; Serpinin-RRG; SL21; SP-I; SS-18; Vasostatin I; Vasostatin II; Vasostatin-1; Vasostatin-2; WA-8; WE-14

more info or order :

Invitrogen product webpage