ErbB3 Monoclonal Antibody (H3.105.5 (Ab105)) | Invitrogen MA5-13008 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ErbB3 Monoclonal Antibody (H3.105.5 (Ab105))

catalog :

MA5-13008

quantity :

500 µL

price :

US 450

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

H3.105.5 (Ab105)

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, blocking or activating experiments

citations: 19

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:50; loading ...; fig 1	El Maassarani M, Barbarin A, Fromont G, Kaissi O, Lebbe M, Vannier B, et al. Integrated and Functional Genomics Analysis Validates the Relevance of the Nuclear Variant ErbB380kDa in Prostate Cancer Progression. PLoS ONE. 2016;11:e0155950 pubmed publisher
flow cytometry; human	Parente Pereira A, Whilding L, Brewig N, van der Stegen S, Davies D, Wilkie S, et al. Synergistic Chemoimmunotherapy of Epithelial Ovarian Cancer Using ErbB-Retargeted T Cells Combined with Carboplatin. J Immunol. 2013;191:2437-45 pubmed publisher
flow cytometry; human	Davies D, Foster J, van der Stegen S, Parente Pereira A, Chiapero Stanke L, Delinassios G, et al. Flexible targeting of ErbB dimers that drive tumorigenesis by using genetically engineered T cells. Mol Med. 2012;18:565-76 pubmed publisher
blocking or activating experiments; human	Zhang K, Wong P, Zhang L, Jacobs B, Borden E, Aster J, et al. A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth. Oncogene. 2012;31:4609-18 pubmed publisher
blocking or activating experiments; rat	Minor K, Bournat J, Toscano N, Giger R, Davies S. Decorin, erythroblastic leukaemia viral oncogene homologue B4 and signal transducer and activator of transcription 3 regulation of semaphorin 3A in central nervous system scar tissue. Brain. 2011;134:1140-55 pubmed publisher
blocking or activating experiments; human; 10 ug/ml immunoprecipitation; human; 10 ug/ml	Forsberg S, Rollman O. Re-epithelialization from human skin explant cultures is promoted by ligand-activated HER3 receptor. J Dermatol Sci. 2010;59:7-15 pubmed publisher
blocking or activating experiments; human	Hernandez L, Smirnova T, Kedrin D, Wyckoff J, Zhu L, Stanley E, et al. The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12. Cancer Res. 2009;69:3221-7 pubmed publisher
immunocytochemistry; human	Proietti C, Rosemblit C, Beguelin W, Rivas M, Díaz Flaqué M, Charreau E, et al. Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth. Mol Cell Biol. 2009;29:1249-65 pubmed publisher
immunocytochemistry; rat western blot; rat	Zscheppang K, Liu W, Volpe M, Nielsen H, Dammann C. ErbB4 regulates fetal surfactant phospholipid synthesis in primary fetal rat type II cells. Am J Physiol Lung Cell Mol Physiol. 2007;293:L429-35 pubmed
immunocytochemistry; mouse	Zscheppang K, Korenbaum E, Bueter W, Ramadurai S, Nielsen H, Dammann C. ErbB receptor dimerization, localization, and co-localization in mouse lung type II epithelial cells. Pediatr Pulmonol. 2006;41:1205-12 pubmed
immunocytochemistry; human western blot; human	Ramsauer V, Pino V, Farooq A, Carothers Carraway C, Salas P, Carraway K. Muc4-ErbB2 complex formation and signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2. Mol Biol Cell. 2006;17:2931-41 pubmed
immunohistochemistry; human; 1:20	Edwards J, Traynor P, Munro A, Pirret C, Dunne B, Bartlett J. The role of HER1-HER4 and EGFRvIII in hormone-refractory prostate cancer. Clin Cancer Res. 2006;12:123-30 pubmed
blocking or activating experiments; rat; 10 ug/ml	Chen J, Tseng H, Dichter M, Zhang H, Greene M. Differential localization of ErbB receptor ensembles influences their signaling in hippocampal neurons. DNA Cell Biol. 2005;24:553-62 pubmed
	Mitchell R, Mikolajczak M, Kersten C, Fleetwood Walker S. ErbB1-dependent signalling and vesicular trafficking in primary afferent nociceptors associated with hypersensitivity in neuropathic pain. Neurobiol Dis. 2020;142:104961 pubmed publisher
	Sims J, Taguiam J, Alonso Valenteen F, Markman J, Agadjanian H, Chu D, et al. Resistance to receptor-blocking therapies primes tumors as targets for HER3-homing nanobiologics. J Control Release. 2018;271:127-138 pubmed publisher
	O charoenrat P, Wongkajornsilp A, Rhys Evans P, Eccles S. Signaling pathways required for matrix metalloproteinase-9 induction by betacellulin in head-and-neck squamous carcinoma cells. Int J Cancer. 2004;111:174-83 pubmed
	Gilmour L, MacLeod K, McCaig A, Sewell J, Gullick W, Smyth J, et al. Neuregulin expression, function, and signaling in human ovarian cancer cells. Clin Cancer Res. 2002;8:3933-42 pubmed
	Shirakawa K, Tsuda H, Heike Y, Kato K, Asada R, Inomata M, et al. Absence of endothelial cells, central necrosis, and fibrosis are associated with aggressive inflammatory breast cancer. Cancer Res. 2001;61:445-51 pubmed
	O charoenrat P, Modjtahedi H, Rhys Evans P, Court W, Box G, Eccles S. Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells. Cancer Res. 2000;60:1121-8 pubmed

product information

Product Type :

Antibody

Product Name :

ErbB3 Monoclonal Antibody (H3.105.5 (Ab105))

Catalog # :

MA5-13008

Quantity :

500 µL

Price :

US 450

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 0.5 µg/test, Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1:1-1:100

Species :

Human, Mouse

Clone :

H3.105.5 (Ab105)

Isotype :

IgG1

Storage :

4° C

Description :

ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents. The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6. 2kb mRNA which is translated into a 160/180 kDa glycoprotein. The ErbB3 gene encodes a transmembrane receptor tyrosine kinase due to alternative splicing and forms heterodimers with other EGF receptor family members that have kinase activity. Heterodimerization leads to the activation of pathways that lead to cell proliferation or differentiation. Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized. One ErbB3 isoform lacks the intermembrane region, is secreted outside the cell, and acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Immunogen :

Extracellular domain of recombinant human c-erbB-3/HER-3 oncoprotein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1:1-1:100

Aliases :

avian erythroblastosis oncogene B 3; avian erythroblastosis oncogene B 3 receptor; C76256; c-erbB3; c-erbB-3; C-errB-3; erb-b2 receptor tyrosine kinase 3; ERBB3; ErbB-3; Erbb3r; erbB3-S; Glial growth factor receptor; HER3; human epidermal growth factor receptor 3; LCCS2; MDA BF 1; MDA-BF-1; MGC88033; nuc-ErbB3; p180 ErbB3; p180-ErbB3; p45 sErbB3; p45-sErbB3; p85 sErbB3; p85-sErbB3; Proto-oncogene-like protein c-ErbB-3; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-3; Tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)