RPSA Monoclonal Antibody (MLuC5) | Invitrogen MA5-12840 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RPSA Monoclonal Antibody (MLuC5)

catalog :

MA5-12840

quantity :

500 µL

price :

US 408.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MLuC5

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 20,000 ng/ml; loading ...; fig 6b western blot; human; loading ...; fig 6a	Wang Q, Wang H, Li Y, Xie Z, Ma Y, Yan J, et al. Inhibition of EMMPRIN and MMP-9 Expression by Epigallocatechin-3-Gallate through 67-kDa Laminin Receptor in PMA-Induced Macrophages. Cell Physiol Biochem. 2016;39:2308-2319 pubmed
western blot; mouse; fig 3 western blot; human; fig 3	Chang A, Krishnan S, Prasadarao N. The effects of cytotoxic necrotizing factor 1 expression in the uptake of Escherichia coli K1 by macrophages and the onset of meningitis in newborn mice. Virulence. 2016;7:806-18 pubmed publisher
blocking or activating experiments; human; 20 ug/ml	Wang Z, Gao W, Wang H, Zhao D, Nie Z, Shi J, et al. Green tea polyphenol epigallocatechin-3-gallate inhibits TNF-α-induced production of monocyte chemoattractant protein-1 in human umbilical vein endothelial cells. Cell Physiol Biochem. 2014;33:1349-58 pubmed publisher
western blot; mouse	Hinojosa C, Mgbemena V, Van Roekel S, Austad S, Miller R, Bose S, et al. Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Exp Gerontol. 2012;47:958-65 pubmed publisher
blocking or activating experiments; human; 5 ug/ml	Li J, Ye L, Wang X, Liu J, Wang Y, Zhou Y, et al. (-)-Epigallocatechin gallate inhibits endotoxin-induced expression of inflammatory cytokines in human cerebral microvascular endothelial cells. J Neuroinflammation. 2012;9:161 pubmed publisher
western blot; human	Fujimura Y, Sumida M, Sugihara K, Tsukamoto S, Yamada K, Tachibana H. Green tea polyphenol EGCG sensing motif on the 67-kDa laminin receptor. PLoS ONE. 2012;7:e37942 pubmed publisher
blocking or activating experiments; mouse	Byun E, Omura T, Yamada K, Tachibana H. Green tea polyphenol epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor. FEBS Lett. 2011;585:814-20 pubmed publisher
flow cytometry; human	Ando K, Miyazaki Y, Sawayama Y, Tominaga S, Matsuo E, Yamasaki R, et al. High expression of 67-kDa laminin receptor relates to the proliferation of leukemia cells and increases expression of GM-CSF receptor. Exp Hematol. 2011;39:179-186.e4 pubmed publisher
blocking or activating experiments; human; 0.1-10 ug/ml western blot; human	Britschgi A, Simon H, Tobler A, Fey M, Tschan M. Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2. Br J Haematol. 2010;149:55-64 pubmed publisher
immunohistochemistry; human; 1:50	Branca M, Giorgi C, Ciotti M, Santini D, Di Bonito L, Costa S, et al. Relationship of up-regulation of 67-kd laminin receptor to grade of cervical intraepithelial neoplasia and to high-risk HPV types and prognosis in cervical cancer. Acta Cytol. 2006;50:6-15 pubmed
	Christie P, Jonas M, Tsai C, Chi E, Henderson W. Increase in laminin expression in allergic airway remodelling and decrease by dexamethasone. Eur Respir J. 2004;24:107-15 pubmed
	Ganor Y, Besser M, Ben Zakay N, Unger T, Levite M. Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration. J Immunol. 2003;170:4362-72 pubmed

image

image 1 :

Formalin-fixed, paraffin-embedded human breast carcinoma stained with Laminin Receptor antibody using peroxidase-conjugate and DAB chromogen. Note cell membrane with some cytoplasmic staining of tumor cells.

product information

Product Type :

Antibody

Product Name :

RPSA Monoclonal Antibody (MLuC5)

Catalog # :

MA5-12840

Quantity :

500 µL

Price :

US 408.00

Clonality :

Monoclonal

Purity :

Ammonium sulfate precipitation

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:10-1:200, Immunohistochemistry (Paraffin): 4-8 µg/mL, Western Blot: 1:10-1:200

Species :

Human

Clone :

MLuC5

Isotype :

IgM

Storage :

4° C

Description :

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Immunogen :

Small cell lung carcinoma N592 live cells

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:10-1:200, Immunohistochemistry (Paraffin): 4-8 µg/mL, Western Blot: 1:10-1:200

Aliases :

37 kDa laminin receptor; 37 kDa laminin receptor precursor; 37 kDa laminin receptor precursor {ECO:0000255; 37 kDa oncofetal antigen; 37/67 kDa laminin receptor; 37/67 kDa laminin receptor {ECO:0000255; 37LRP; 37LRP {ECO:0000255; 40S ribosomal protein SA; 40S ribosomal protein SA {ECO:0000255; 67 kDa laminin receptor; 67 kDa laminin receptor {ECO:0000255; 67kDa; 67LR; 67LR {ECO:0000255; AL022858; colon carcinoma laminin-binding protein; HAMAP-Rule:MF_03016}; ICAS; LAMBR; Laminin receptor 1; laminin receptor 1 (67kD, ribosomal protein SA); laminin receptor 1 (ribosomal protein SA); laminin receptor 1 {ECO:0000255; laminin-binding protein precursor p40; laminin-binding protein precursor p40 {ECO:0000255; LamR; lamR {ECO:0000255; LAMR1; Lamrl1; LBP; LBP/p40; LBP/p40 {ECO:0000255; LRP; LRP/LR; LRP/LR {ECO:0000255; MLR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; OFA/iLRP; p40; P40-3; P40-3, functional; P40-8; P40-8, functional; ribosomal protein SA; Rpsa; rssa; SA; Small ribosomal subunit protein uS2

more info or order :

Invitrogen product webpage