This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
MAP2 Monoclonal Antibody (AP18)
catalog :
MA5-12826
quantity :
500 µL
price :
US 496.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
AP18
reactivity :
guinea pig, human, mouse, rat, dogs, bovine, Xenopus laevis
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 41
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; loading ...; fig 3f
Gao J, Wu Y, He D, Zhu X, Li H, Liu H, et al. Anti-aging effects of Ribes meyeri anthocyanins on neural stem cells and aging mice. Aging (Albany NY). 2020;12:17738-17753 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig st11
  • immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig st11
  • immunohistochemistry - paraffin section; dogs; 1:200; loading ...; fig st11
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
  • immunocytochemistry; human; 1:300; fig 3a
Begum A, Aguilar J, Elias L, Hong Y. Silver nanoparticles exhibit coating and dose-dependent neurotoxicity in glutamatergic neurons derived from human embryonic stem cells. Neurotoxicology. 2016;57:45-53 pubmed publisher
  • immunocytochemistry; human; fig 1
Watanabe Y, Sakuma C, Yaginuma H. NRP1-mediated Sema3A signals coordinate laminar formation in the developing chick optic tectum. Development. 2014;141:3572-82 pubmed publisher
  • immunohistochemistry; mouse
Baek I, Kim T, Seo J, Lee K, Lee Y, Cho J, et al. AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease. Exp Neurobiol. 2013;22:31-7 pubmed publisher
  • immunohistochemistry; human; 1:200
Park J, Kim M, Kim C, Kim J. Intracranial extraskeletal myxoid chondrosarcoma : case report and literature review. J Korean Neurosurg Soc. 2012;52:246-9 pubmed publisher
  • immunocytochemistry; human; 1:200
Nishiyama M, Togashi K, von Schimmelmann M, Lim C, Maeda S, Yamashita N, et al. Semaphorin 3A induces CaV2.3 channel-dependent conversion of axons to dendrites. Nat Cell Biol. 2011;13:676-85 pubmed publisher
  • immunohistochemistry; human; 1:3000
Dulai M, Caccamo D, Briley A, Edwards M, Fisher P, Lehman N. Intramedullary papillary ependymoma with choroid plexus differentiation and cerebrospinal fluid dissemination to the brain. J Neurosurg Pediatr. 2010;5:511-7 pubmed publisher
  • immunocytochemistry; human; 1:300
Esposito G, Scuderi C, Lu J, Savani C, De Filippis D, Iuvone T, et al. S100B induces tau protein hyperphosphorylation via Dickopff-1 up-regulation and disrupts the Wnt pathway in human neural stem cells. J Cell Mol Med. 2008;12:914-27 pubmed publisher
  • immunocytochemistry; human
Raso A, Negri F, Gregorio A, Nozza P, Mascelli S, De Marco P, et al. Successful isolation and long-term establishment of a cell line with stem cell-like features from an anaplastic medulloblastoma. Neuropathol Appl Neurobiol. 2008;34:306-15 pubmed
  • immunohistochemistry; rat
van Vliet E, Stoppini L, Balestrino M, Eskes C, Griesinger C, Sobanski T, et al. Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects. Neurotoxicology. 2007;28:1136-46 pubmed
  • immunocytochemistry; mouse
Mitsui S, Yamaguchi N, Osako Y, Yuri K. Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation. Brain Res. 2007;1136:1-12 pubmed
  • immunohistochemistry; mouse; 1:1000
Tian G, Lai L, Guo H, Lin Y, Butchbach M, Chang Y, et al. Translational control of glial glutamate transporter EAAT2 expression. J Biol Chem. 2007;282:1727-37 pubmed
  • immunocytochemistry; rat
Chen J, Tseng H, Dichter M, Zhang H, Greene M. Differential localization of ErbB receptor ensembles influences their signaling in hippocampal neurons. DNA Cell Biol. 2005;24:553-62 pubmed
  • immunohistochemistry; guinea pig; 1:100
Kan R, Pleva C, Hamilton T, Petrali J. Immunolocalization of MAP-2 in routinely formalin-fixed, paraffin-embedded guinea pig brain sections using microwave irradiation: a comparison of different combinations of antibody clones and antigen retrieval buffer solutions. Microsc Microanal. 2005;11:175-80 pubmed
Telesford K, Smith C, Mettlen M, Davis M, COWELL L, Kittles R, et al. Neuron-binding antibody responses are associated with Black ethnicity in multiple sclerosis during natalizumab treatment. Brain Commun. 2023;5:fcad218 pubmed publisher
Zoabi S, Andreyanov M, Heinrich R, Ron S, Carmi I, Gutfreund Y, et al. A custom-made AAV1 variant (AAV1-T593K) enables efficient transduction of Japanese quail neurons in vitro and in vivo. Commun Biol. 2023;6:337 pubmed publisher
Pediaditakis I, Kodella K, Manatakis D, Le C, Barthakur S, Sorets A, et al. A microengineered Brain-Chip to model neuroinflammation in humans. iScience. 2022;25:104813 pubmed publisher
Tashiro R, Bautista Garrido J, Ozaki D, Sun G, Obertas L, Mobley A, et al. Transplantation of astrocytic mitochondria modulates neuronal antioxidant defense and neuroplasticity and promotes functional recovery after intracerebral hemorrhage. J Neurosci. 2022;42:7001-14 pubmed publisher
Kim J, Kim Y, Lee S, Jung C, Kim M, Kim D. Neuroprotective Effect of Macrophage Migration Inhibitory Factor (MIF) in a Mouse Model of Ischemic Stroke. Int J Mol Sci. 2022;23: pubmed publisher
Tsui M, Biro J, Chan J, Min W, Dobbs K, Notarangelo L, et al. Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced pluripotent stem cell-derived neurons. Sci Rep. 2022;12:9084 pubmed publisher
Scalise S, Zannino C, Lucchino V, Lo Conte M, Scaramuzzino L, Cifelli P, et al. Human iPSC Modeling of Genetic Febrile Seizure Reveals Aberrant Molecular and Physiological Features Underlying an Impaired Neuronal Activity. Biomedicines. 2022;10: pubmed publisher
Lu V, Roy I, Torres A, Joly J, Ahsan F, Graham N, et al. Glutamine-dependent signaling controls pluripotent stem cell fate. Dev Cell. 2022;57:610-623.e8 pubmed publisher
Urrutia Cabrera D, Hsiang Chi Liou R, Lin J, Shi Y, Liu K, Hung S, et al. Combinatorial Approach of Binary Colloidal Crystals and CRISPR Activation to Improve Induced Pluripotent Stem Cell Differentiation into Neurons. ACS Appl Mater Interfaces. 2022;14:8669-8679 pubmed publisher
Challagundla N, Agrawal Rajput R. microRNAs (miR 9, 124, 155 and 224) transdifferentiate mouse macrophages to neurons. Exp Cell Res. 2021;402:112563 pubmed publisher
Chlebowski A, Kisby G. Protocol for High-Throughput Screening of Neural Cell or Brain Tissue Protein Using a Dot-Blot Technique with Near-Infrared Imaging. STAR Protoc. 2020;1: pubmed publisher
Bae S, Yoo M, Kim Y, Hong I, Kim M, Lee S, et al. Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation. Neural Regen Res. 2020;15:1483-1489 pubmed publisher
Drobnik J, Pietrucha K, Janczar K, Polis L, Polis B, Safandowska M, et al. Intra-cerebral implantation of a variety of collagenous scaffolds with nervous embryonic cells. Exp Ther Med. 2019;18:4758-4764 pubmed publisher
Itoh K, Murata D, Kato T, Yamada T, Araki Y, Saito A, et al. Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division. elife. 2019;8: pubmed publisher
Gill S, Kumara V. Detecting Neurodevelopmental Toxicity of Domoic Acid and Ochratoxin A Using Rat Fetal Neural Stem Cells. Mar Drugs. 2019;17: pubmed publisher
Navarro González C, Huerga Gómez A, Fazzari P. Nrg1 Intracellular Signaling Is Neuroprotective upon Stroke. Oxid Med Cell Longev. 2019;2019:3930186 pubmed publisher
Dominguez G, Maddelein M, Pucelle M, Nicaise Y, Maurage C, Duyckaerts C, et al. Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain. Acta Neuropathol Commun. 2018;6:25 pubmed publisher
Repar N, Li H, Aguilar J, Li Q, Drobne D, Hong Y. Silver nanoparticles induce neurotoxicity in a human embryonic stem cell-derived neuron and astrocyte network. Nanotoxicology. 2018;12:104-116 pubmed publisher
Gumy L, Katrukha E, Grigoriev I, Jaarsma D, Kapitein L, Akhmanova A, et al. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Neuron. 2017;94:347-362.e7 pubmed publisher
Begum A, Guoynes C, Cho J, Hao J, Lutfy K, Hong Y. Rapid generation of sub-type, region-specific neurons and neural networks from human pluripotent stem cell-derived neurospheres. Stem Cell Res. 2015;15:731-741 pubmed publisher
Zurich M, Honegger P, Schilter B, Costa L, Monnet Tschudi F. Involvement of glial cells in the neurotoxicity of parathion and chlorpyrifos. Toxicol Appl Pharmacol. 2004;201:97-104 pubmed
Wang Y, Bai Y, Li X, Hu Q, Lin C, Xiao Z, et al. Fetal human neural progenitors can be the target for tumor transformation. Neuroreport. 2004;15:1907-12 pubmed
Eskes C, Juillerat Jeanneret L, Leuba G, Honegger P, Monnet Tschudi F. Involvement of microglia-neuron interactions in the tumor necrosis factor-alpha release, microglial activation, and neurodegeneration induced by trimethyltin. J Neurosci Res. 2003;71:583-90 pubmed
Farah C, Nguyen M, Julien J, Leclerc N. Altered levels and distribution of microtubule-associated proteins before disease onset in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2003;84:77-86 pubmed
Dobashi Y, Shoji M, Kitagawa M, Noguchi T, Kameya T. Simultaneous suppression of cdc2 and cdk2 activities induces neuronal differentiation of PC12 cells. J Biol Chem. 2000;275:12572-80 pubmed
Lin S, Constantine Paton M. Suppression of sprouting: An early function of NMDA receptors in the absence of AMPA/kainate receptor activity. J Neurosci. 1998;18:3725-37 pubmed
product information
Product Type :
Antibody
Product Name :
MAP2 Monoclonal Antibody (AP18)
Catalog # :
MA5-12826
Quantity :
500 µL
Price :
US 496.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Avian, Bovine, Human, Mouse, Rat, Xenopus laevis
Applications :
Immunocytochemistry: 1:500-1:1,000, Immunohistochemistry (Paraffin): 1-2 µg/mL, Western Blot: 1-2 µg/mL
Species :
Avian, Bovine, Human, Mouse, Rat, Xenopus laevis
Clone :
AP18
Isotype :
IgG1
Storage :
4° C
Description :
MAP2 (Microtubule Associated Protein 2) exists in two high molecular weight forms (MAP2a & MAP2b) and a low molecular weight form. The expression of MAP2 is developmentally regulated and its multiple forms arise by alternative splicing of a single gene. MAP2 is involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. MAP2 is useful in studies of neuron structure in normal and malignant brain tissue as well as in degenerative diseases such as Alzheimer's Disease (AD).
Immunogen :
Bovine brain microtubule associated protein 2
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:500-1:1,000, Immunohistochemistry (Paraffin): 1-2 µg/mL, Western Blot: 1-2 µg/mL
Aliases :
a730034c02; AC091465.1; DKFZp686I2148; G1-397-34; MAP 2; Map2; MAP-2; map2.S; map2a; map-2a; map2ab; MAP2B; MAP2C; MAP2R; microtubule associated protein 2; microtubule associated protein 2 S homeolog; microtubule associated protein 2; microtubule-associated protein 2; microtubule associated protein 2C; microtubule-associated protein 2; microtubule-associated protein-2; Mtap2; Mtap-2; OTTHUMP00000163916; OTTHUMP00000208143; repro4; XELAEV_18047318mg; xmap2
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA