MAP2 Monoclonal Antibody (AP20) | Invitrogen MA5-12823 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MAP2 Monoclonal Antibody (AP20)

catalog :

MA5-12823

quantity :

500 µL

price :

US 446.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AP20

reactivity :

Epinephelus, African green monkey, human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 29

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig s7a	Tamaki Y, Shodai A, Morimura T, Hikiami R, Minamiyama S, Ayaki T, et al. Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals. Sci Rep. 2018;8:6030 pubmed publisher
immunocytochemistry; Epinephelus; fig 1a	Chiang Y, Wu Y, Chi S. Interleukin-1Î² secreted from betanodavirus-infected microglia caused the death of neurons in giant grouper brains. Dev Comp Immunol. 2017;70:19-26 pubmed publisher
immunocytochemistry; mouse; 1:200; tbl 1	Buren C, Tu G, Parsons M, Sepers M, Raymond L. Influence of cortical synaptic input on striatal neuronal dendritic arborization and sensitivity to excitotoxicity in corticostriatal coculture. J Neurophysiol. 2016;116:380-90 pubmed publisher
immunohistochemistry - paraffin section; human; 1:400	Yarchoan M, Toledo J, Lee E, Arvanitakis Z, Kazi H, Han L, et al. Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta Neuropathol. 2014;128:679-89 pubmed publisher
immunohistochemistry; rat; tbl 1	Cakici C, Buyrukcu B, Duruksu G, Haliloglu A, Aksoy A, Isik A, et al. Recovery of fertility in azoospermia rats after injection of adipose-tissue-derived mesenchymal stem cells: the sperm generation. Biomed Res Int. 2013;2013:529589 pubmed publisher
immunohistochemistry; human	Sarnat H, Flores Sarnat L. Precocious and delayed neocortical synaptogenesis in fetal holoprosencephaly. Clin Neuropathol. 2013;32:255-68 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:6000; fig 7	Karasinska J, de Haan W, Franciosi S, Ruddle P, Fan J, Kruit J, et al. ABCA1 influences neuroinflammation and neuronal death. Neurobiol Dis. 2013;54:445-55 pubmed publisher
immunohistochemistry; human	Sarnat H, Flores Sarnat L, Crino P, Hader W, Bello Espinosa L. Hemimegalencephaly: foetal tauopathy with mTOR hyperactivation and neuronal lipidosis. Folia Neuropathol. 2012;50:330-45 pubmed
immunocytochemistry; human	Raso A, Vecchio D, Cappelli E, Ropolo M, Poggi A, Nozza P, et al. Characterization of glioma stem cells through multiple stem cell markers and their specific sensitization to double-strand break-inducing agents by pharmacological inhibition of ataxia telangiectasia mutated protein. Brain Pathol. 2012;22:677-88 pubmed publisher
immunocytochemistry; rat; 1:500	Sheng H, Xu Y, Chen Y, Zhang Y, Xu X, He C, et al. CRH-R1 and CRH-R2 differentially modulate dendritic outgrowth of hippocampal neurons. Endocrine. 2012;41:458-64 pubmed publisher
immunocytochemistry; rat; 1:200	Zhou Z, Xu Y, Zhong Q, Zheng J. Phenotypic characteristics of hybrid cells generated by transferring neuronal nuclei into bone marrow stromal cell cytoplasts. Brain Res Bull. 2012;87:303-11 pubmed publisher
immunohistochemistry; rat	Adas G, Arikan S, Karatepe O, Kemik O, Ayhan S, Karaoz E, et al. Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study). Langenbecks Arch Surg. 2011;396:115-26 pubmed publisher
immunohistochemistry; human; 1:100	Cardoso C, Bornstein S, Hornsby P. Optimizing orthotopic cell transplantation in the mouse adrenal gland. Cell Transplant. 2010;19:565-72 pubmed publisher
immunohistochemistry; mouse	Jiang Z, Belforte J, Lu Y, Yabe Y, Pickel J, Smith C, et al. eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation. J Neurosci. 2010;30:2582-94 pubmed publisher
immunohistochemistry; human; 1:200	Bai Y, Du L, Shen L, Zhang Y, Zhang L. GPR56 is highly expressed in neural stem cells but downregulated during differentiation. Neuroreport. 2009;20:918-22 pubmed publisher
immunohistochemistry; mouse	Fitzgerald D, Cole S, Hammond A, Seaman C, Cooper H. Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain. Neuroscience. 2006;142:703-16 pubmed
immunohistochemistry; human; 1:200	Garbelli R, Meroni A, Magnaghi G, Beolchi M, Ferrario A, Tassi L, et al. Architectural (Type IA) focal cortical dysplasia and parvalbumin immunostaining in temporal lobe epilepsy. Epilepsia. 2006;47:1074-8 pubmed
immunocytochemistry; rat; 1:200	Xu X, He C, Zhang Z, Chen Y. MKLP1 requires specific domains for its dendritic targeting. J Cell Sci. 2006;119:452-8 pubmed
immunocytochemistry; human	Denham M, Huynh T, Dottori M, Allen G, Trounson A, Mollard R. Neural stem cells express non-neural markers during embryoid body coculture. Stem Cells. 2006;24:918-27 pubmed
immunocytochemistry; African green monkey; 1:400	Hu Q, Saegusa H, Hayashi Y, Tanabe T. The carboxy-terminal tail region of human Cav2.1 (P/Q-type) channel is not an essential determinant for its subcellular localization in cultured neurones. Genes Cells. 2005;10:87-96 pubmed
flow cytometry; human; 1:100 immunocytochemistry; human; 1:100	Li X, Xu J, Bai Y, Wang X, Dai X, Liu Y, et al. Isolation and characterization of neural stem cells from human fetal striatum. Biochem Biophys Res Commun. 2005;326:425-34 pubmed
	Li C, Coffey E, Dall Agnese A, Hannett N, Tang X, Henninger J, et al. MeCP2 links heterochromatin condensates and neurodevelopmental disease. Nature. 2020;586:440-444 pubmed publisher
	Le Large T, El Hassouni B, Funel N, Kok B, Piersma S, Pham T, et al. Proteomic analysis of gemcitabine-resistant pancreatic cancer cells reveals that microtubule-associated protein 2 upregulation associates with taxane treatment. Ther Adv Med Oncol. 2019;11:1758835919841233 pubmed publisher
	Karaoz E, Tepekoy F, Yılmaz I, Subasi C, Kabatas S. Reduction of Inflammation and Enhancement of Motility after Pancreatic Islet Derived Stem Cell Transplantation Following Spinal Cord Injury. J Korean Neurosurg Soc. 2019;62:153-165 pubmed publisher
	Schmidt M, Buren C, Mackay J, Cheung D, Dal Cengio L, Raymond L, et al. Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease. BMC Biol. 2018;16:58 pubmed publisher
	Tsutsui K, Grabenhorst F, Kobayashi S, Schultz W. A dynamic code for economic object valuation in prefrontal cortex neurons. Nat Commun. 2016;7:12554 pubmed publisher
	Karaoz E, Kabatas S, Duruksu G, Okçu A, Subasi C, Ay B, et al. Reduction of lesion in injured rat spinal cord and partial functional recovery of motility after bone marrow derived mesenchymal stem cell transplantation. Turk Neurosurg. 2012;22:207-17 pubmed publisher
	Marcinkiewicz M. BetaAPP and furin mRNA concentrates in immature senile plaques in the brain of Alzheimer patients. J Neuropathol Exp Neurol. 2002;61:815-29 pubmed
	Lin S, Constantine Paton M. Suppression of sprouting: An early function of NMDA receptors in the absence of AMPA/kainate receptor activity. J Neurosci. 1998;18:3725-37 pubmed

image

image 1 :

Formalin-fixed, paraffin-embedded human brain stained with Microtubulessociated Protein 2a,b antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of the neurons and dendrites.

product information

Product Type :

Antibody

Product Name :

MAP2 Monoclonal Antibody (AP20)

Catalog # :

MA5-12823

Quantity :

500 µL

Price :

US 446.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Bovine, Human

Applications :

Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 1:100-200, Western Blot: 1:20-50

Species :

Bovine, Human

Clone :

AP20

Isotype :

IgG1

Storage :

4° C

Description :

MAP2 (Microtubule Associated Protein 2) exists in two high molecular weight forms (MAP2a & MAP2b) and a low molecular weight form. The expression of MAP2 is developmentally regulated and its multiple forms arise by alternative splicing of a single gene. MAP2 is involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. MAP2 is useful in studies of neuron structure in normal and malignant brain tissue as well as in degenerative diseases such as Alzheimer's Disease (AD).

Immunogen :

Bovine brain microtubule associated protein 2

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 1:100-200, Western Blot: 1:20-50

Aliases :

a730034c02; AC091465.1; DKFZp686I2148; G1-397-34; MAP 2; Map2; MAP-2; map2.S; map2a; map-2a; map2ab; MAP2B; MAP2C; MAP2R; microtubule associated protein 2; microtubule associated protein 2 S homeolog; microtubule associated protein 2; microtubule-associated protein 2; microtubule associated protein 2C; microtubule-associated protein 2; microtubule-associated protein-2; Mtap2; Mtap-2; OTTHUMP00000163916; OTTHUMP00000208143; repro4; XELAEV_18047318mg; xmap2

more info or order :

Invitrogen product webpage