This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Fibrillin 1 Monoclonal Antibody (11C1.3)
catalog :
MA5-12770
quantity :
500 µL
price :
US 456.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
11C1.3
reactivity :
human, bovine, pigs
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
citations: 27
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; fig 1
Zoppi N, Chiarelli N, Cinquina V, Ritelli M, Colombi M. GLUT10 deficiency leads to oxidative stress and non-canonical αvβ3 integrin-mediated TGFβ signalling associated with extracellular matrix disarray in arterial tortuosity syndrome skin fibroblasts. Hum Mol Genet. 2015;24:6769-87 pubmed publisher
  • immunocytochemistry; human; 1:1000
  • western blot; human; 1:5000
Fujita T, Tsuruga E, Yamanouchi K, Sawa Y, Ishikawa H. Microfibril-associated glycoprotein-1 controls human ciliary zonule development in vitro. Acta Histochem Cytochem. 2014;47:11-7 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:1000
  • immunohistochemistry; human; 1:1000
Langton A, Sherratt M, Sellers W, Griffiths C, Watson R. Geographical ancestry is a key determinant of epidermal morphology and dermal composition. Br J Dermatol. 2014;171:274-82 pubmed publisher
  • immunocytochemistry; human; 1:1000
Kawagoe M, Tsuruga E, Oka K, Sawa Y, Ishikawa H. Matrix metalloproteinase-2 degrades fibrillin-1 and fibrillin-2 of oxytalan fibers in the human eye and periodontal ligaments in vitro. Acta Histochem Cytochem. 2013;46:153-9 pubmed publisher
  • immunohistochemistry; human; 1:1000
Tsuruga E, Oka K, Hatakeyama Y, Isokawa K, Sawa Y. Latent transforming growth factor-? binding protein 2 negatively regulates coalescence of oxytalan fibers induced by stretching stress. Connect Tissue Res. 2012;53:521-7 pubmed publisher
  • immunohistochemistry; human; 1:100
Rizwan M, Rodriguez Blanco I, Harbottle A, Birch Machin M, Watson R, Rhodes L. Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial. Br J Dermatol. 2011;164:154-62 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Wipff J, Avouac J, Le Charpentier M, Varret M, Houtteman A, Ruiz B, et al. Dermal tissue and cellular expression of fibrillin-1 in diffuse cutaneous systemic sclerosis. Rheumatology (Oxford). 2010;49:657-61 pubmed publisher
  • immunocytochemistry; human
  • immunohistochemistry; human
Bertram C, Hass R. Cellular senescence of human mammary epithelial cells (HMEC) is associated with an altered MMP-7/HB-EGF signaling and increased formation of elastin-like structures. Mech Ageing Dev. 2009;130:657-69 pubmed publisher
  • immunohistochemistry; human; 1:100
Watson R, Ogden S, Cotterell L, Bowden J, Bastrilles J, Long S, et al. Effects of a cosmetic 'anti-ageing' product improves photoaged skin [corrected]. Br J Dermatol. 2009;161:419-26 pubmed publisher
  • western blot; human; 1:100
Lee D, Yang J, Park K. A dermal equivalent developed from fibroblast culture alone: effect of EGF and insulin. Wound Repair Regen. 2007;15:936-9 pubmed
  • immunohistochemistry; pigs
Lin C, Lai L, Lin J, Sun Y, Hsu C, Chen C, et al. Increased expression of extracellular matrix proteins in rapid atrial pacing-induced atrial fibrillation. Heart Rhythm. 2007;4:938-49 pubmed
  • immunocytochemistry; human; 1:100
Ahmed S, Tan F, Arnett F, Jin L, Geng Y. Induction of apoptosis and fibrillin 1 expression in human dermal endothelial cells by scleroderma sera containing anti-endothelial cell antibodies. Arthritis Rheum. 2006;54:2250-62 pubmed
  • immunohistochemistry; human
Kim H, Cho S, Lee S, Kim K, Cho K, Eun H, et al. Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo. J Lipid Res. 2006;47:921-30 pubmed
  • immunohistochemistry; human
Natoli A, Medley T, Ahimastos A, Drew B, Thearle D, Dilley R, et al. Sex steroids modulate human aortic smooth muscle cell matrix protein deposition and matrix metalloproteinase expression. Hypertension. 2005;46:1129-34 pubmed
  • immunohistochemistry; human; 1:500
Kim M, Lee S, Rho H, Kim D, Chang I, Chung J. The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo. Clin Chim Acta. 2005;362:161-9 pubmed
  • immunohistochemistry; human; 1:100
  • western blot; human
Chen Z, Seo J, Kim Y, Lee S, Kim K, Cho K, et al. Heat modulation of tropoelastin, fibrillin-1, and matrix metalloproteinase-12 in human skin in vivo. J Invest Dermatol. 2005;124:70-8 pubmed
Ceccacci S, Lucia A, Tortora A, Colantuono A, Carotenuto G, Tito A, et al. Jasminum sambac Cell Extract as Antioxidant Booster against Skin Aging. Antioxidants (Basel). 2022;11: pubmed publisher
Wang X, Shi X, Lu H, Zhang C, Li X, Zhang T, et al. Succinylation Inhibits the Enzymatic Hydrolysis of the Extracellular Matrix Protein Fibrillin 1 and Promotes Gastric Cancer Progression. Adv Sci (Weinh). 2022;9:e2200546 pubmed publisher
Huang K, Wang Y, Siu K, Zhang Y, Cai H. Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics. Redox Biol. 2020;38:101757 pubmed publisher
Danalache M, Erler A, Wolfgart J, Schwitalle M, Hofmann U. Biochemical changes of the pericellular matrix and spatial chondrocyte organization-Two highly interconnected hallmarks of osteoarthritis. J Orthop Res. 2020;38:2170-2180 pubmed publisher
Gerhart J, Withers C, Gerhart C, Werner L, Mamalis N, Bravo Nuevo A, et al. Myo/Nog cells are present in the ciliary processes, on the zonule of Zinn and posterior capsule of the lens following cataract surgery. Exp Eye Res. 2018;171:101-105 pubmed publisher
Chiarelli N, Carini G, Zoppi N, Ritelli M, Colombi M. Transcriptome analysis of skin fibroblasts with dominant negative COL3A1 mutations provides molecular insights into the etiopathology of vascular Ehlers-Danlos syndrome. PLoS ONE. 2018;13:e0191220 pubmed publisher
Bogdanowicz P, Haure M, Ceruti I, Bessou Touya S, Castex Rizzi N. Results from in vitro and ex vivo skin aging models assessing the antiglycation and anti-elastase MMP-12 potential of glycylglycine oleamide. Clin Cosmet Investig Dermatol. 2016;9:143-50 pubmed publisher
Lepreux S, Desmouliere A, Rosenbaum J, Balabaud C, Bioulac Sage P. Expression of fibrillin-1 in focal nodular hyperplasia of the liver: a role in microcirculation adaptability. Comp Hepatol. 2004;3 Suppl 1:S57 pubmed
Bax D, Bernard S, Lomas A, Morgan A, Humphries J, Shuttleworth C, et al. Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins. J Biol Chem. 2003;278:34605-16 pubmed
Lamireau T, Dubuisson L, Lepreux S, Bioulac Sage P, Fabre M, Rosenbaum J, et al. Abnormal hepatic expression of fibrillin-1 in children with cholestasis. Am J Surg Pathol. 2002;26:637-46 pubmed
Baldock C, Koster A, Ziese U, Rock M, Sherratt M, Kadler K, et al. The supramolecular organization of fibrillin-rich microfibrils. J Cell Biol. 2001;152:1045-56 pubmed
product information
Product Type :
Antibody
Product Name :
Fibrillin 1 Monoclonal Antibody (11C1.3)
Catalog # :
MA5-12770
Quantity :
500 µL
Price :
US 456.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Bovine, Human
Applications :
Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Immunomicroscopy: Assay-dependent, Western Blot: 1-2 µg/mL
Species :
Bovine, Human
Clone :
11C1.3
Isotype :
IgG1, kappa
Storage :
4° C
Description :
Fibrillin 1 is an extracellular acidic protein with a high cysteine content and an extended thread-like shape with mosaic composition of different types of extracellular modules. Most of the fibrillin molecule is contributed by 47 epidermal growth factor-like (EGF-like) repeats; 43 of them have a consensus sequence for calcium binding (cb). Other modules including 8-cysteine motifs (seven), hybrid motifs (two), and unique domains (three) are interspersed throughout the molecule[3-7]. Fibrillin 1 contains a proline-rich region close to the N-terminus that is replaced by a glycine-rich region in Fibrillin 2. The fibrillins are found throughout the connective tissue as integral components of extended fibrils.
Immunogen :
Microfibrils from zonular apparatus of bovine eye
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Immunomicroscopy: Assay-dependent, Western Blot: 1-2 µg/mL
Aliases :
ACMICD; AI536462; Asprosin; B430209H23; ECTOL1; FBN; Fbn1; Fbn-1; Fib-1; fibrillin 1; fibrillin 15; fibrillin-1; GPHYSD2; MASS; MFLS; MFS1; MP340; OCTD; putative; SGS; SSKS; tight skin; Tsk; WMS; WMS2
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA