Cyclin D2 Antibody Cocktail | Invitrogen MA5-12731 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cyclin D2 Antibody Cocktail

catalog :

MA5-12731

quantity :

500µL

price :

US 345

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DCS-3.1 + DCS-5.2

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 16

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...	Turner J, Kashyap T, Dawson J, Gomez J, Bauer A, Grant S, et al. XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IÎºBÎ± and overcomes acquired proteasome inhibitor resistance in human multiple myeloma. Oncotarget. 2016;7:78896-78909 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:100	Mirzaa G, Parry D, Fry A, Giamanco K, Schwartzentruber J, Vanstone M, et al. De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. Nat Genet. 2014;46:510-515 pubmed publisher
immunohistochemistry; mouse	Komada M, Iguchi T, Takeda T, Ishibashi M, Sato M. Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortex. Neurosci Lett. 2013;547:87-91 pubmed publisher
western blot; mouse; 1:400	Yang Y, Chang B, Chan L. Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults. EMBO Mol Med. 2013;5:92-104 pubmed publisher
immunoprecipitation; mouse western blot; mouse	Zhang Q, Sakamoto K, Liu C, Triplett A, Lin W, Rui H, et al. Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression. Cancer Res. 2011;71:7513-24 pubmed publisher
western blot; human	Stein J, Milewski W, Hara M, Steiner D, Dey A. GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1). Islets. 2011;3:21-34 pubmed
immunohistochemistry; mouse western blot; mouse	He L, Sartori D, Teta M, Opare Addo L, Rankin M, Long S, et al. Cyclin D2 protein stability is regulated in pancreatic beta-cells. Mol Endocrinol. 2009;23:1865-75 pubmed publisher
western blot; mouse	Rankin M, Kushner J. Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes. 2009;58:1365-72 pubmed publisher
immunohistochemistry; mouse; 1:1000	Glickstein S, Moore H, Slowinska B, Racchumi J, Suh M, Chuhma N, et al. Selective cortical interneuron and GABA deficits in cyclin D2-null mice. Development. 2007;134:4083-93 pubmed
immunohistochemistry; mouse; 1:500	Pogoriler J, Millen K, Utset M, Du W. Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation. Development. 2006;133:3929-37 pubmed
western blot; rat; 1:200; loading ...; fig 1b	Friedrichsen B, Richter H, Hansen J, Rhodes C, Nielsen J, Billestrup N, et al. Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells. Mol Endocrinol. 2003;17:945-58 pubmed
	Jirawatnotai S, Aziyu A, Osmundson E, Moons D, Zou X, Kineman R, et al. Cdk4 is indispensable for postnatal proliferation of the anterior pituitary. J Biol Chem. 2004;279:51100-6 pubmed
	Chen B, Pollard J. Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation. Mol Endocrinol. 2003;17:1368-81 pubmed
	Clark W, Black E, MacLaren A, Kruse U, LaThangue N, Vogt P, et al. v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity. Mol Cell Biol. 2000;20:2529-42 pubmed
	Tsutsui T, Hesabi B, Moons D, Pandolfi P, Hansel K, Koff A, et al. Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Mol Cell Biol. 1999;19:7011-9 pubmed
	Ladha M, Lee K, Upton T, Reed M, Ewen M. Regulation of exit from quiescence by p27 and cyclin D1-CDK4. Mol Cell Biol. 1998;18:6605-15 pubmed

product information

Product Type :

Antibody

Product Name :

Cyclin D2 Antibody Cocktail

Catalog # :

MA5-12731

Quantity :

500µL

Price :

US 345

Clonality :

Cocktail

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1-2 µg/mL, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:20, Western Blot: Assay Dependent

Species :

Human, Mouse, Rat

Clone :

DCS-3.1 + DCS-5.2

Isotype :

IgG2a/IgG2b

Storage :

4° C

Description :

Cyclin D2 is a G1 cyclin required for G1 phase progression and is a strong candidate for a proto-oncogene. Cyclin D2 can phosphorylate pRB when associated with cdk 4 and / or cdk 6.

Immunogen :

Purified histidine-tagged human recombinant full length cyclin D2 protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1-2 µg/mL, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:20, Western Blot: Assay Dependent

Aliases :

2600016F06Rik; AI256817; BF642806; C86853; CCND2; cD2; cyclin D2; Cyl-2; G1/S-specific cyclin-D2; KIAK0002; MGC102758; MPPH3; Vin1; Vin-1; Vin-1 proto-oncogene