Cyclin D1 Monoclonal Antibody (DCS-6) | Invitrogen MA5-12702 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cyclin D1 Monoclonal Antibody (DCS-6)

catalog :

MA5-12702

quantity :

500µL

price :

US 309

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DCS-6

reactivity :

human, mouse, rat, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 123

Reference
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Chen B, Pollard J. Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation. Mol Endocrinol. 2003;17:1368-81 pubmed
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Vogt B, Rossman T. Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicity. Mutat Res. 2001;478:159-68 pubmed
Schulze A, Lehmann K, Jefferies H, McMahon M, Downward J. Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev. 2001;15:981-94 pubmed
Kirma N, Gill K, Mandava U, Tekmal R. Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice. Cancer Res. 2001;61:1910-8 pubmed
Dunphy C, Perkins S. Large cell variants of CD5+, CD23- B-cell lymphoma/leukemia. Arch Pathol Lab Med. 2001;125:513-8 pubmed
Maitra A, Roberts H, Weinberg A, Geradts J. Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. Int J Cancer. 2001;95:34-8 pubmed
Soria J, Morat L, Commo F, Dabit D, Perie S, Sabatier L, et al. Telomerase activation cooperates with inactivation of p16 in early head and neck tumorigenesis. Br J Cancer. 2001;84:504-11 pubmed
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product information

Product Type :

Antibody

Product Name :

Cyclin D1 Monoclonal Antibody (DCS-6)

Catalog # :

MA5-12702

Quantity :

500µL

Price :

US 309

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Non-human primate, Rat

Applications :

Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL

Species :

Canine, Human, Mouse, Non-human primate, Rat

Clone :

DCS-6

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL). In addition, cyclin D1 positively regulates protein phosphorylation, mammary gland epithelial cell proliferation, and fat cell differentiation. In humans, the CCND1 gene encoding cyclin D1 is present on chromosome 11. Cyclin D1 is a cytoplasmic and nuclear protein that is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation. D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation, and titrate CDK inhibitors such as p21Cip1 and p27Kip1. Without growth factor-mediated stimulation, Cyclin D1 is unstable, and undergoes ubiquitin-mediated degradation, which is triggered by its phosphorylation. Cyclin D1 destabilization participates in G1/S phase arrest. The Cyclin D1 protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The Cyclin D1 protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities.

Immunogen :

Human recombinant full length cyclin D1 protein

Format :

Liquid

Applications w/Dilutions :

Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL

Aliases :

B-cell CLL/lymphoma 1, B-cell lymphoma 1 protein, BCL-1 oncogene, G1/S-specific cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene