CD25 Monoclonal Antibody (IL2R.1) | Invitrogen MA5-12680 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD25 Monoclonal Antibody (IL2R.1)

catalog :

MA5-12680

quantity :

500 µL

price :

US 410.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

IL2R.1

reactivity :

human, mouse, cat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 12

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:200	Lu Z, Chen W, Ju C, Den J, Kuai S, Pei H, et al. CD25 is a novel marker of hepatic bile canaliculus. Int J Surg Pathol. 2012;20:455-61 pubmed
immunohistochemistry; human; 1:60	Tao X, Xia J, Chen X, Wang H, Dai Y, Rhodus N, et al. FOXP3 T regulatory cells in lesions of oral lichen planus correlated with disease activity. Oral Dis. 2010;16:76-82 pubmed publisher
immunohistochemistry; mouse	Miyazaki T, Doy M, Unno R, Honda A, Ikegami T, Itoh S, et al. Regulatory T cells and liver pathology in a murine graft versus host response model. Hepatol Res. 2009;39:585-94 pubmed publisher
western blot; human	Tricaud N, Perrin Tricaud C, BRUSES J, Rutishauser U. Adherens junctions in myelinating Schwann cells stabilize Schmidt-Lanterman incisures via recruitment of p120 catenin to E-cadherin. J Neurosci. 2005;25:3259-69 pubmed
immunohistochemistry; human; 1:20	Matsusaka T, Xin J, Niwa S, Kobayashi K, Akatsuka A, Hashizume H, et al. Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. J Am Soc Nephrol. 2005;16:1013-23 pubmed
western blot; cat	Willey C, Balasubramanian S, Rodríguez Rosas M, Ross R, Kuppuswamy D. Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src. J Mol Cell Cardiol. 2003;35:671-83 pubmed
	Nickl V, Eck J, Goedert N, H xfc bner J, Nerreter T, Hagemann C, et al. Characterization and Optimization of the Tumor Microenvironment in Patient-Derived Organotypic Slices and Organoid Models of Glioblastoma. Cancers (Basel). 2023;15: pubmed publisher
	Wang L, Rajavel M, Wu C, Zhang C, Poindexter M, Fulgar C, et al. Effects of life-stage and passive tobacco smoke exposure on pulmonary innate immunity and influenza infection in mice. J Toxicol Environ Health A. 2022;85:439-456 pubmed publisher
	Shaw A, Qasem A, Naser S. Modulation of PTPN2/22 Function by Spermidine in CRISPR-Cas9-Edited T-Cells Associated with Crohn's Disease and Rheumatoid Arthritis. Int J Mol Sci. 2021;22: pubmed publisher
	Costa A, Kieffer Y, Scholer Dahirel A, Pelon F, Bourachot B, Cardon M, et al. Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer. Cancer Cell. 2018;33:463-479.e10 pubmed publisher
	Zhou J, Bethune M, Malkova N, Sutherland A, Comin Anduix B, Su Y, et al. A kinetic investigation of interacting, stimulated T cells identifies conditions for rapid functional enhancement, minimal phenotype differentiation, and improved adoptive cell transfer tumor eradication. PLoS ONE. 2018;13:e0191634 pubmed publisher
	Gray C, Arosio P, Hersey P. Association of increased levels of heavy-chain ferritin with increased CD4+ CD25+ regulatory T-cell levels in patients with melanoma. Clin Cancer Res. 2003;9:2551-9 pubmed

product information

Product Type :

Antibody

Product Name :

CD25 Monoclonal Antibody (IL2R.1)

Catalog # :

MA5-12680

Quantity :

500 µL

Price :

US 410.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:100-1:500

Species :

Human, Mouse

Clone :

IL2R.1

Isotype :

IgG1, kappa

Storage :

4° C

Description :

CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.

Immunogen :

Recombinant human interleukin-2 receptor

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:100-1:500

Aliases :

ADA; ADA1; Adenosine aminohydrolase; adenosine deaminase; CD25; CD25 antigen; cytokine receptor; IDDM10; IL 2 RA; IL 2 receptor; IL 2R; IL 2R subunit alpha; IL2 RA; IL2 RA antibody; IL2 receptor; il-2 receptor alpha; IL-2 Receptor alpha chain; IL-2 receptor alpha subunit; IL2 receptor subunit alpha; IL-2 receptor subunit alpha; IL2R; IL-2R alpha; IL-2R alpha chain; IL2R subunit alpha; IL-2R subunit alpha; Il2ra; IL-2RA; IL-2-RA; IL2-RA; Il2ra antibody; IL2RAC; IMD41; interleukin 2 receptor; interleukin 2 receptor alpha chain; interleukin 2 receptor subunit alpha; interleukin 2 receptor, alpha; interleukin 2 receptor, alpha chain; interleukin-2 receptor alpha; interleukin-2 receptor alpha chain; interleukin-2 receptor alpha subunit; interleukin-2 receptor beta chain; Interleukin2 receptor subunit alpha; interleukin-2 receptor subunit alpha; Ly-43; p55; p55 chain; sIL 2R; soluble IL 2 receptor; TAC antigen; TCGFR