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company name :
Invitrogen
other brands :
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product type :
antibody
product name :
Cytokeratin 19 Monoclonal Antibody (A53-B/A2.26 (Ks19.1))
catalog :
MA5-12663
quantity :
500 µL
price :
US 315.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
A53-B/A2.26 (Ks19.1)
reactivity :
human, mouse, domestic sheep, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, reverse phase protein lysate microarray
more info or order :
Invitrogen product webpage
citations: 50
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; fig 6c
Hendricks Wenger A, Aycock K, Nagai Singer M, Coutermarsh Ott S, Lorenzo M, Gannon J, et al. Establishing an immunocompromised porcine model of human cancer for novel therapy development with pancreatic adenocarcinoma and irreversible electroporation. Sci Rep. 2021;11:7584 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig 7a
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 1c
  • western blot; human; 1:1000; loading ...; fig 2c
Britschgi A, Duss S, Kim S, Couto J, Brinkhaus H, Koren S, et al. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Nature. 2017;541:541-545 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 1c
Erdogan Durmus S, Ozcan D, Yarikkaya E, Kurt A, Arslan A. CD56, HBME-1 and cytokeratin 19 expressions in papillary thyroid carcinoma and nodular thyroid lesions. J Res Med Sci. 2016;21:49 pubmed
  • immunohistochemistry; human; 1:100
Cetin S, Kir G, Yilmaz M. Thyroid Paraganglioma Diagnosed by Fine-Needle Aspiration Biopsy, Correlated With Histopathological Findings: Report of a Case. Diagn Cytopathol. 2016;44:643-7 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2000; fig 4
  • western blot; human; fig 4
Fleury H, Communal L, Carmona E, Portelance L, Arcand S, Rahimi K, et al. Novel high-grade serous epithelial ovarian cancer cell lines that reflect the molecular diversity of both the sporadic and hereditary disease. Genes Cancer. 2015;6:378-398 pubmed
  • immunohistochemistry - paraffin section; human; fig s1
Labouba I, Le Page C, Communal L, Kristessen T, You X, Péant B, et al. Potential Cross-Talk between Alternative and Classical NF-κB Pathways in Prostate Cancer Tissues as Measured by a Multi-Staining Immunofluorescence Co-Localization Assay. PLoS ONE. 2015;10:e0131024 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1c
Trimboli P, Guidobaldi L, Amendola S, Nasrollah N, Romanelli F, Attanasio D, et al. Galectin-3 and HBME-1 improve the accuracy of core biopsy in indeterminate thyroid nodules. Endocrine. 2016;52:39-45 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 7
Huo C, Chew G, Hill P, Huang D, Ingman W, Hodson L, et al. High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium. Breast Cancer Res. 2015;17:79 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
Fatourou E, Koskinas J, Karandrea D, Palaiologou M, Syminelaki T, Karanikolas M, et al. Keratin 19 protein expression is an independent predictor of survival in human hepatocellular carcinoma. Eur J Gastroenterol Hepatol. 2015;27:1094-102 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 1
Hines W, Yaswen P, Bissell M. Modelling breast cancer requires identification and correction of a critical cell lineage-dependent transduction bias. Nat Commun. 2015;6:6927 pubmed publisher
  • immunohistochemistry; human
Yassin F. Diagnostic criteria of well differentiated thyroid tumor of uncertain malignant potential; a histomorphological and immunohistochemical appraisal. J Egypt Natl Canc Inst. 2015;27:59-67 pubmed publisher
  • immunohistochemistry - paraffin section; human
Chen Q, Gu Y, Liu B. Clinicopathological characteristics of kidney mucinous tubular and spindle cell carcinoma. Int J Clin Exp Pathol. 2015;8:1007-12 pubmed
  • immunohistochemistry; human
Pınarlı F, Okten G, Beden U, Fisgin T, Kefeli M, Kara N, et al. Keratinocyte growth factor-2 and autologous serum potentiate the regenerative effect of mesenchymal stem cells in cornea damage in rats. Int J Ophthalmol. 2014;7:211-9 pubmed publisher
  • immunohistochemistry; human; 1:100
Güney G, Tezel G, Kosemehmetoglu K, Yilmaz E, Balci S, Ersoy R, et al. Molecular features of follicular variant papillary carcinoma of thyroid: comparison of areas with or without classical nuclear features. Endocr Pathol. 2014;25:241-7 pubmed publisher
  • immunohistochemistry; human; 1:100
Ozer S, Kayahan B, Cabbarzade C, Buğdayci M, Kosemehmetoglu K, Yücel O. Thyroid-like papillary adenocarcinoma of the nasopharynx with focal thyroglobulin expression. Pathology. 2013;45:622-4 pubmed publisher
  • immunohistochemistry; human; 1:1500
Kim W, Ko Y, Hwang T, Han H, Lim S, Kim W, et al. A Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with BRAF K601E Mutation and Three Conventional Types with BRAF V600E Mutation. Korean J Pathol. 2013;47:293-8 pubmed publisher
  • immunohistochemistry; human; 1:400
Zhang X, Claerhout S, Prat A, Dobrolecki L, Petrovic I, Lai Q, et al. A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models. Cancer Res. 2013;73:4885-97 pubmed publisher
  • immunocytochemistry; human
Moffatt Jauregui C, Robinson B, de Moya A, Brockman R, Roman A, Cash M, et al. Establishment and characterization of a telomerase immortalized human gingival epithelial cell line. J Periodontal Res. 2013;48:713-21 pubmed publisher
  • western blot; human; fig 4
Takahashi Y, Kupferman M, Bell D, Jiffar T, Lee J, Xie T, et al. Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. Clin Cancer Res. 2012;18:6178-87 pubmed publisher
  • immunohistochemistry; human
  • western blot; human
Létourneau I, Quinn M, Wang L, Portelance L, Caceres K, Cyr L, et al. Derivation and characterization of matched cell lines from primary and recurrent serous ovarian cancer. BMC Cancer. 2012;12:379 pubmed publisher
  • immunohistochemistry; human; fig 1
Guimei M, Baddour N, Elkaffash D, Abdou L, Taher Y. Gremlin in the pathogenesis of hepatocellular carcinoma complicating chronic hepatitis C: an immunohistochemical and PCR study of human liver biopsies. BMC Res Notes. 2012;5:390 pubmed publisher
  • immunohistochemistry; human; 1:1500
Ko Y, Hwang T, Han H, Lim S, Kim W, Oh S. Primary pure squamous cell carcinoma of the thyroid: report and histogenic consideration of a case involving a BRAF mutation. Pathol Int. 2012;62:43-8 pubmed publisher
  • immunohistochemistry; human; 1:150
Sarsik B, Simsir A, Karaarslan S, Sen S. Mucinous tubular and spindle cell carcinoma of kidney and problems in diagnosis. Turk Patoloji Derg. 2011;27:116-26 pubmed publisher
  • immunohistochemistry; human
Eloy C, Vinagre J, Cameselle Teijeiro J, Paiva M, Soares P, Sobrinho Simoes M. Tumor-in-tumor of the thyroid with basaloid differentiation: a lesion with a solid cell nest neoplastic component?. Int J Surg Pathol. 2011;19:276-80 pubmed publisher
  • immunocytochemistry; human; 1:500
Sartoneva R, Haimi S, Miettinen S, Mannerström B, Haaparanta A, Sándor G, et al. Comparison of a poly-L-lactide-co-?-caprolactone and human amniotic membrane for urothelium tissue engineering applications. J R Soc Interface. 2011;8:671-7 pubmed publisher
  • immunohistochemistry; human; 1:1000
Moreira J, Cabezon T, Gromova I, Gromov P, Timmermans Wielenga V, Machado I, et al. Tissue proteomics of the human mammary gland: towards an abridged definition of the molecular phenotypes underlying epithelial normalcy. Mol Oncol. 2010;4:539-61 pubmed publisher
  • immunohistochemistry; human; 1:100
Huang S, Xu Y, Wu C, Sha D, Fu X. In vitro constitution and in vivo implantation of engineered skin constructs with sweat glands. Biomaterials. 2010;31:5520-5 pubmed publisher
  • immunohistochemistry; human; 1:50
Nasr M, Mukhopadhyay S, Zhang S, Katzenstein A. Absence of the BRAF mutation in HBME1+ and CK19+ atypical cell clusters in Hashimoto thyroiditis: supportive evidence against preneoplastic change. Am J Clin Pathol. 2009;132:906-12 pubmed publisher
  • western blot; human; 1:200
Chang C, Chiou P, Chen W, Li Y, Yiu J, Cheng Y, et al. Assessment of the tumorigenesis and drug susceptibility of three new canine mammary tumor cell lines. Res Vet Sci. 2010;88:285-93 pubmed publisher
  • immunocytochemistry; mouse; 1:50
Behbod F, Kittrell F, LaMarca H, Edwards D, Kerbawy S, Heestand J, et al. An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. Breast Cancer Res. 2009;11:R66 pubmed publisher
  • immunocytochemistry; human
  • immunohistochemistry; human
Metallo C, Azarin S, Moses L, Ji L, de Pablo J, Palecek S. Human embryonic stem cell-derived keratinocytes exhibit an epidermal transcription program and undergo epithelial morphogenesis in engineered tissue constructs. Tissue Eng Part A. 2010;16:213-23 pubmed publisher
  • immunocytochemistry; mouse
Kawashima M, Kawakita T, Yoshida S, Shimmura S, Tsubota K. Nucleostemin as a possible progenitor marker of corneal epithelial cells. Mol Vis. 2009;15:1162-8 pubmed
  • immunocytochemistry; human
  • immunohistochemistry; human
  • western blot; human
Celis J, Gromova I, Cabezon T, Gromov P, Shen T, Timmermans Wielenga V, et al. Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease. Mol Oncol. 2007;1:321-49 pubmed publisher
  • immunohistochemistry; human
  • western blot; human
Celis J, Moreira J, Gromova I, Cabezon T, Gromov P, Shen T, et al. Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia. Mol Oncol. 2007;1:97-119 pubmed publisher
  • immunohistochemistry; human; 1:100
Li H, Zhou G, Fu X, Zhang L. Antigen expression of human eccrine sweat glands. J Cutan Pathol. 2009;36:318-24 pubmed publisher
  • immunohistochemistry; human
Celis J, Gromov P, Cabezon T, Moreira J, Friis E, Jirstrom K, et al. 15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma. Mol Cell Proteomics. 2008;7:1795-809 pubmed publisher
  • immunocytochemistry; domestic sheep; 1:100
Liu Y, Zhou H, Gao F. Isolation and identification of stem cells from adult cashmere goat skin. Int J Dermatol. 2008;47:551-6 pubmed publisher
  • immunohistochemistry; human
Svoboda M, Sellner F, Ekmekcioglu C, Klimpfinger M, Jaeger W, Thalhammer T. Expression of estrogen-metabolizing enzymes and estrogen receptors in cholelithiasis gallbladder. Biomed Pharmacother. 2008;62:690-6 pubmed publisher
  • immunohistochemistry; rhesus macaque; 1:100
Wood C, Hester J, Cline J. Mammary gland development in early pubertal female macaques. Toxicol Pathol. 2007;35:795-805 pubmed
  • immunocytochemistry; domestic sheep
Islam M, Zhou H. Isolation and characterization of putative epidermal stem cells derived from Cashmere goat fetus. Eur J Dermatol. 2007;17:302-8 pubmed
  • immunohistochemistry; human
Gurbuz Y, Kose N, Aydin O, Ozturk M. An immunohistochemical profile of giant cell carcinoma of the larynx. Auris Nasus Larynx. 2007;34:413-6 pubmed
  • immunohistochemistry; human; 1:50
Nasr M, Mukhopadhyay S, Zhang S, Katzenstein A. Immunohistochemical markers in diagnosis of papillary thyroid carcinoma: Utility of HBME1 combined with CK19 immunostaining. Mod Pathol. 2006;19:1631-7 pubmed
  • immunohistochemistry; human
Yesim G, Gupse T, Zafer U, Ahmet A. Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients. J Hepatobiliary Pancreat Surg. 2005;12:502-7 pubmed
  • western blot; human
Moreira J, Ohlsson G, Rank F, Celis J. Down-regulation of the tumor suppressor protein 14-3-3sigma is a sporadic event in cancer of the breast. Mol Cell Proteomics. 2005;4:555-69 pubmed
Schreurs O, Karatsaidis A, Balta M, Grung B, Hals E, Schenck K. Expression of keratins 8, 18, and 19 in epithelia of atrophic oral lichen planus. Eur J Oral Sci. 2020;128:7-17 pubmed publisher
Shik Mun K, Arora K, Huang Y, Yang F, Yarlagadda S, Ramananda Y, et al. Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders. Nat Commun. 2019;10:3124 pubmed publisher
Aust S, Obrist P, Jaeger W, Klimpfinger M, Tucek G, Wrba F, et al. Subcellular localization of the ABCG2 transporter in normal and malignant human gallbladder epithelium. Lab Invest. 2004;84:1024-36 pubmed
Apaydin R, Gurbuz Y, Bayramgurler D, Muezzinoglu B, Bilen N. Cytokeratin expression in lichen amyloidosus and macular amyloidosis. J Eur Acad Dermatol Venereol. 2004;18:305-9 pubmed
Gudjonsson T, Villadsen R, Nielsen H, Rønnov Jessen L, Bissell M, Petersen O. Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev. 2002;16:693-706 pubmed
image
image 1 :
Invitrogen MA5-12663 image 1
image 2 :
Invitrogen MA5-12663 image 2
Formalin-fixed, paraffin-embedded human skin stained with Keratin 19 antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of epithelial cells in the sweat glands.
product information
Product Type :
Antibody
Product Name :
Cytokeratin 19 Monoclonal Antibody (A53-B/A2.26 (Ks19.1))
Catalog # :
MA5-12663
Quantity :
500 µL
Price :
US 315.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human
Applications :
Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 2 µg/mL
Species :
Human
Clone :
A53-B/A2.26 (Ks19.1)
Isotype :
IgG2a, lambda
Storage :
4° C
Description :
Cytokeratin 19 is part of a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight from 40-68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. For example, cytokeratin 19 is not expressed in hepatocytes, therefore, it is useful in the identification of liver metastasis.
Immunogen :
Human breast cancer MCF-7 cells
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 2 µg/mL
Aliases :
40-kDa keratin intermediate filament; AI663979; C K1CS; CK 19; CK19; CK-19; cytokeratin 19; cytokeratin-19; EndoC; K19; K1CS; Ka19; keratin 19; keratin 19, type I; keratin complex 1, acidic, gene 19; keratin, type I cytoskeletal 19; keratin, type I, 40-kd; keratin-19; Krt-1.19; Krt1-19; Krt19; LOC100344434; MGC15366; Type I keratin Ka19
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA