Progesterone Receptor Monoclonal Antibody (hPRa 6) | Invitrogen MA5-12653 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Progesterone Receptor Monoclonal Antibody (hPRa 6)

catalog :

MA5-12653

quantity :

500 µL

price :

US 413.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

hPRa 6

reactivity :

human, mouse, chicken, bovine, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; chicken; 4 ug/ml; fig 2	GonzÃ¡lez MorÃ¡n M. Immunohistochemical localization of progesterone receptor isoforms and estrogen receptor alpha in the chicken oviduct magnum during development. Acta Histochem. 2015;117:681-7 pubmed publisher
immunohistochemistry; human; 1:25 western blot; human	Kariagina A, Xie J, Leipprandt J, Haslam S. Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers. Horm Cancer. 2010;1:229-44 pubmed publisher
immunohistochemistry; mouse; 1:50	Zhang C, Mori M, Gao S, Li A, Hoshino I, Aupperlee M, et al. Tip30 deletion in MMTV-Neu mice leads to enhanced EGFR signaling and development of estrogen receptor-positive and progesterone receptor-negative mammary tumors. Cancer Res. 2010;70:10224-33 pubmed publisher
immunohistochemistry; mouse; 1:200 western blot; mouse; 2 ug/ml	Wargon V, Fernandez S, Goin M, Giulianelli S, Russo J, Lanari C. Hypermethylation of the progesterone receptor A in constitutive antiprogestin-resistant mouse mammary carcinomas. Breast Cancer Res Treat. 2011;126:319-32 pubmed publisher
western blot; mouse; 2 ug/ml	Wargon V, Helguero L, Bolado J, Rojas P, Novaro V, Molinolo A, et al. Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomas. Breast Cancer Res Treat. 2009;116:449-60 pubmed publisher
immunohistochemistry; human; 1:200	Bukulmez O, Hardy D, Carr B, Word R, Mendelson C. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. Endocrinology. 2008;149:1190-204 pubmed
immunohistochemistry; human; 1:40	Leslie K, Walter S, Torkko K, Stephens J, Thompson C, Singh M. Effect of tamoxifen on endometrial histology, hormone receptors, and cervical cytology: a prospective study with follow-up. Appl Immunohistochem Mol Morphol. 2007;15:284-93 pubmed
immunocytochemistry; human; 1:500	Velarde M, Zeng Z, McQuown J, Simmen F, Simmen R. Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells. Mol Endocrinol. 2007;21:2988-3001 pubmed
immunohistochemistry; human	Singh M, Zaino R, Filiaci V, Leslie K. Relationship of estrogen and progesterone receptors to clinical outcome in metastatic endometrial carcinoma: a Gynecologic Oncology Group Study. Gynecol Oncol. 2007;106:325-33 pubmed
immunohistochemistry; human; 1:20	Oh S, Kim C, Park I, Romero R, Sohn Y, Moon K, et al. Progesterone receptor isoform (A/B) ratio of human fetal membranes increases during term parturition. Am J Obstet Gynecol. 2005;193:1156-60 pubmed
immunoprecipitation; human; 5 ug/time immunohistochemistry; human; 1:25 western blot; human	Leslie K, Stein M, Kumar N, Dai D, Stephens J, Wandinger Ness A, et al. Progesterone receptor isoform identification and subcellular localization in endometrial cancer. Gynecol Oncol. 2005;96:32-41 pubmed
	Nagy A, Sathe S, Atta A, Hammam A, Hsu W. Characterization of Nuclear Progesterone Receptor Isoforms in the Term Equine Placenta. Front Vet Sci. 2021;8:660177 pubmed publisher
	González Morán G, Camacho Arroyo I. Changes in the presence of progesterone receptor isoforms in the oviduct magnum of newly-hatched chicks after gonadotropins treatment. Life Sci. 2003;73:871-82 pubmed
	González Morán G, García Izquierdo J, Camacho Arroyo I. Progesterone receptor isoforms in ovary of newly-hatched chick after gonadotropin treatment during embryonic development. Comp Biochem Physiol A Mol Integr Physiol. 2002;132:519-26 pubmed
	González Agüero G, Ondarza R, Gamboa Dominguez A, Cerbon M, Camacho Arroyo I. Progesterone receptor isoforms expression pattern in human astrocytomas. Brain Res Bull. 2001;56:43-8 pubmed

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product information

Product Type :

Antibody

Product Name :

Progesterone Receptor Monoclonal Antibody (hPRa 6)

Catalog # :

MA5-12653

Quantity :

500 µL

Price :

US 413.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Bovine, Chicken, Human, Rabbit

Applications :

Immunocytochemistry: Assay-dependent, Immunoprecipitation: 2 µg/mL

Species :

Bovine, Chicken, Human, Rabbit

Clone :

hPRa 6

Isotype :

IgG2b

Storage :

4° C

Description :

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.

Immunogen :

Partially purified PgR from a human endometrial carcinoma (EnCa 101) grown in athymic mice

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Immunoprecipitation: 2 µg/mL

Aliases :

9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product

more info or order :

Invitrogen product webpage