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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Progesterone Receptor Monoclonal Antibody (hPRa 2)
catalog :
MA5-12642
quantity :
500 µL
price :
US 453.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
hPRa 2
reactivity :
human, cat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 58
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; cat; loading ...; fig 1b
Granados Soler J, Bornemann Kolatzki K, Beck J, Brenig B, Schütz E, Betz D, et al. Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival. Sci Rep. 2020;10:1003 pubmed publisher
Grzegorzewska A, Grot E, Sechman A. Sodium Fluoride In Vitro Treatment Affects the Expression of Gonadotropin and Steroid Hormone Receptors in Chicken Embryonic Gonads. Animals (Basel). 2021;11: pubmed publisher
Menendez J, Peirce S, Papadimitropoulou A, Cuyàs E, Steen T, Verdura S, et al. Progesterone receptor isoform-dependent cross-talk between prolactin and fatty acid synthase in breast cancer. Aging (Albany NY). 2020;12:24671-24692 pubmed publisher
Pezzolato M, Botta M, Baioni E, Richelmi G, Pitardi D, Varello K, et al. Confirmation of the progesterone receptor as an efficient marker of treatment with 17β-estradiol in veal calves. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016;33:60-5 pubmed publisher
Nelis H, Wojciechowicz B, Franczak A, Leemans B, D Herde K, Goossens K, et al. Steroids affect gene expression, ciliary activity, glucose uptake, progesterone receptor expression and immunoreactive steroidogenic protein expression in equine oviduct explants in vitro. Reprod Fertil Dev. 2016;28:1926-1944 pubmed publisher
Nelis H, Vanden Bussche J, Wojciechowicz B, Franczak A, Vanhaecke L, Leemans B, et al. Steroids in the equine oviduct: synthesis, local concentrations and receptor expression. Reprod Fertil Dev. 2015;: pubmed publisher
de Sant Ana F, Carvalho F, de O Gamba C, Cassali G, Riet Correa F, Schild A. Mammary diffuse fibroadenomatoid hyperplasia in water buffalo (Bubalus bubalis): three cases. J Vet Diagn Invest. 2014;26:453-456 pubmed
Dressing G, Knutson T, Schiewer M, Daniel A, Hagan C, Diep C, et al. Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells. Mol Endocrinol. 2014;28:442-57 pubmed publisher
Hussein O, Mosbah M, Farouk O, Farag K, El Saed A, Arafa M, et al. Hormone receptors and age distribution in breast cancer patients at a university hospital in northern egypt. Breast Cancer (Auckl). 2013;7:51-7 pubmed publisher
Pezzolato M, Richelmi G, Maurella C, Pitardi D, Varello K, Caramelli M, et al. Histopathology as a simple and reliable method to detect 17?-oestradiol illegal treatment in male calves. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30:1096-9 pubmed publisher
Palm F, Walter I, Nowotny N, Budik S, Helmreich M, Aurich C. Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor, and cyclooxygenase 2 in fetal membranes and endometrium from pony mares at parturition. Theriogenology. 2013;79:59-68 pubmed publisher
D Amato N, OSTRANDER J, Bowie M, Sistrunk C, Borowsky A, Cardiff R, et al. Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system. PLoS ONE. 2012;7:e45684 pubmed publisher
Machado S, Bahr J, Hales D, Braundmeier A, Quade B, Nowak R. Validation of the aging hen (Gallus gallus domesticus) as an animal model for uterine leiomyomas. Biol Reprod. 2012;87:86 pubmed publisher
Wang N, Geng L, Zhang S, He B, Wang J. Expression of PRB, FKBP52 and HB-EGF relating with ultrasonic evaluation of endometrial receptivity. PLoS ONE. 2012;7:e34010 pubmed publisher
Almeida Francia C, Keator C, Mah K, Holden L, Hergert C, Slayden O. Localization and hormonal regulation of endometrial matrix metalloproteinase-26 in the rhesus macaque. Hum Reprod. 2012;27:1723-34 pubmed publisher
van der Horst P, Wang Y, Vandenput I, Kühne L, Ewing P, van Ijcken W, et al. Progesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer. PLoS ONE. 2012;7:e30840 pubmed publisher
Charles N, Thomas P, Lange C. Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events. Horm Cancer. 2010;1:167-76 pubmed publisher
Martignani E, Eirew P, Accornero P, Eaves C, Baratta M. Human milk protein production in xenografts of genetically engineered bovine mammary epithelial stem cells. PLoS ONE. 2010;5:e13372 pubmed publisher
Kim H, Kim M, Ahn S, Son B, Kim S, Ahn J, et al. Different prognostic significance of CD24 and CD44 expression in breast cancer according to hormone receptor status. Breast. 2011;20:78-85 pubmed publisher
Saruhan B, Sagsoz H, Akbalik M, Ketani M. Distribution of estrogen receptor ? and progesterone receptor B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study. Biotech Histochem. 2011;86:315-25 pubmed publisher
Sagsoz H, Akbalik M, Saruhan B, Ketani M. Localization of estrogen receptor ? and progesterone receptor B in bovine cervix and vagina during the follicular and luteal phases of the sexual cycle. Biotech Histochem. 2011;86:262-71 pubmed publisher
Sharrow A, Ronnett B, Thoburn C, Barber J, Giuntoli R, Armstrong D, et al. Identification and characterization of a spontaneous ovarian carcinoma in Lewis rats. J Ovarian Res. 2010;3:9 pubmed publisher
Ferreira E, Gobbi H, Saraiva B, Cassali G. Columnar cell lesions of the canine mammary gland: pathological features and immunophenotypic analysis. BMC Cancer. 2010;10:61 pubmed publisher
Afhüppe W, Beekman J, Otto C, Korr D, Hoffmann J, Fuhrmann U, et al. In vitro characterization of ZK 230211--A type III progesterone receptor antagonist with enhanced antiproliferative properties. J Steroid Biochem Mol Biol. 2010;119:45-55 pubmed publisher
Chang C, Chiou P, Chen W, Li Y, Yiu J, Cheng Y, et al. Assessment of the tumorigenesis and drug susceptibility of three new canine mammary tumor cell lines. Res Vet Sci. 2010;88:285-93 pubmed publisher
Wang Y, Hanifi Moghaddam P, Hanekamp E, Kloosterboer H, Franken P, Veldscholte J, et al. Progesterone inhibition of Wnt/beta-catenin signaling in normal endometrium and endometrial cancer. Clin Cancer Res. 2009;15:5784-93 pubmed publisher
Misirlioglu D, Nak D, Ozyigit M, Nak Y, Akkoc A. HER-2/neu (c-erbB-2) oncoprotein in hyperplastic endometrial polyps detected in two cats. J Feline Med Surg. 2009;11:885-8 pubmed publisher
Gul A, Ugur M, Iskender C, Zulfikaroglu E, Ozaksit G. Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and its relationship to clinical parameters. Arch Gynecol Obstet. 2010;281:479-83 pubmed publisher
Chakravarty D, Gupta N, Goda J, Srinivasan R, Patel F, Dhaliwal L. Steroid receptors, HER2/neu and Ki-67, in endometrioid type of endometrial carcinoma: Correlation with conventional histomorphological features of prognosis. Acta Histochem. 2010;112:355-63 pubmed publisher
Yanagawa Y, Matsuura Y, Suzuki M, Katagiri S, Tsubota T. Immunohistochemical localization of the estrogen receptor alpha (ERalpha) and progesterone receptor (PR) in the uterus of sika deer (Cervus nippon) during pregnancy. Jpn J Vet Res. 2008;56:139-49 pubmed
Chakravarty D, Srinivasan R, Ghosh S, Rajwanshi A, Gopalan S. Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma. Appl Immunohistochem Mol Morphol. 2008;16:535-42 pubmed publisher
Honorat M, Mesnier A, Di Pietro A, Lin V, Cohen P, Dumontet C, et al. Dexamethasone down-regulates ABCG2 expression levels in breast cancer cells. Biochem Biophys Res Commun. 2008;375:308-14 pubmed publisher
Martin I, Torres Neto R, Oba E, Buratini J, Binelli M, Laufer Amorim R, et al. Immunohistochemical detection of receptors for oestrogen and progesterone in endometrial glands and stroma during the oestrous cycle in Nelore (Bos taurus indicus) cows. Reprod Domest Anim. 2008;43:415-21 pubmed publisher
Yaren A, Kelten C, Akbulut M, Teke Z, Duzcan E, Erdem E. Primary neuroendocrine carcinoma of the breast: a case report. Tumori. 2007;93:496-8 pubmed
Slayden O, Keator C. Role of progesterone in nonhuman primate implantation. Semin Reprod Med. 2007;25:418-30 pubmed
Brayman M, Dharmaraj N, Lagow E, Carson D. MUC1 expression is repressed by protein inhibitor of activated signal transducer and activator of transcription-y. Mol Endocrinol. 2007;21:2725-37 pubmed
Hanifi Moghaddam P, Sijmons B, Ott M, van Ijcken W, Nowzari D, Kuhne E, et al. The hormone replacement therapy drug tibolone acts very similar to medroxyprogesterone acetate in an estrogen-and progesterone-responsive endometrial cancer cell line. J Mol Endocrinol. 2006;37:405-13 pubmed
Ishizuka M, Hatori M, Dohi O, Suzuki T, Miki Y, Tazawa C, et al. Expression profiles of sex steroid receptors in desmoid tumors. Tohoku J Exp Med. 2006;210:189-98 pubmed
Faivre E, Lange C. Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells. Mol Cell Biol. 2007;27:466-80 pubmed
Valle G, Cassali G, Nogueira J, Castro A, Reis A, Cardoso F, et al. Nuclear estrogen and progesterone receptors in the oviduct of heifers under natural and superovulated estrous cycles. Anim Reprod Sci. 2007;101:28-37 pubmed
Saito S, Ito K, Nagase S, Suzuki T, Akahira J, Okamura K, et al. Progesterone receptor isoforms as a prognostic marker in human endometrial carcinoma. Cancer Sci. 2006;97:1308-14 pubmed
Cabioglu N, Sahin A, Doucet M, Yavuz E, Igci A, O Yildirim E, et al. Chemokine receptor CXCR4 expression in breast cancer as a potential predictive marker of isolated tumor cells in bone marrow. Clin Exp Metastasis. 2005;22:39-46 pubmed
Akhan S, Yavuz E, Tecer A, Iyibozkurt C, Topuz S, Tuzlali S, et al. The expression of Ki-67, p53, estrogen and progesterone receptors affecting survival in uterine leiomyosarcomas. A clinicopathologic study. Gynecol Oncol. 2005;99:36-42 pubmed
Mrusek S, Classen Linke I, Vloet A, Beier H, Krusche C. Estradiol and medroxyprogesterone acetate regulated genes in T47D breast cancer cells. Mol Cell Endocrinol. 2005;235:39-50 pubmed
Hasegawa J, Yanaihara A, Iwasaki S, Otsuka Y, Negishi M, Akahane T, et al. Reduction of progesterone receptor expression in human cumulus cells at the time of oocyte collection during IVF is associated with good embryo quality. Hum Reprod. 2005;20:2194-200 pubmed
Fritah A, Saucier C, Mester J, Redeuilh G, Sabbah M. p21WAF1/CIP1 selectively controls the transcriptional activity of estrogen receptor alpha. Mol Cell Biol. 2005;25:2419-30 pubmed
Zheng Z, Bay B, Aw S, Lin V. A novel antiestrogenic mechanism in progesterone receptor-transfected breast cancer cells. J Biol Chem. 2005;280:17480-7 pubmed
Nishimura Y, Watanabe J, Jobo T, Hattori M, Arai T, Kuramoto H. Cytologic scoring of endometrioid adenocarcinoma of the endometrium. Cancer. 2005;105:8-12 pubmed
Skildum A, Faivre E, Lange C. Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases. Mol Endocrinol. 2005;19:327-39 pubmed
Guler G, Uner A, Guler N, Han S, Iliopoulos D, Hauck W, et al. The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. Cancer. 2004;100:1605-14 pubmed
Roberts K, Bhatia K, Stanton P, Lord R. Proteomic analysis of selected prognostic factors of breast cancer. Proteomics. 2004;4:784-92 pubmed
Abd Elaziz M, Akahira J, Moriya T, Suzuki T, Yaegashi N, Sasano H. Nuclear receptor DAX-1 in human common epithelial ovarian carcinoma: an independent prognostic factor of clinical outcome. Cancer Sci. 2003;94:980-5 pubmed
Hanekamp E, Gielen S, Smid Koopman E, Kuhne L, De Ruiter P, Chadha Ajwani S, et al. Consequences of loss of progesterone receptor expression in development of invasive endometrial cancer. Clin Cancer Res. 2003;9:4190-9 pubmed
González Morán G, Camacho Arroyo I. Changes in the presence of progesterone receptor isoforms in the oviduct magnum of newly-hatched chicks after gonadotropins treatment. Life Sci. 2003;73:871-82 pubmed
McLaughlin M, Jacks T. Progesterone receptor expression in neurofibromas. Cancer Res. 2003;63:752-5 pubmed
Joki Erkkilä M, Karikoski R, Rantala I, Lenko H, Visakorpi T, Heinonen P. Gonadoblastoma and dysgerminoma associated with XY gonadal dysgenesis in an adolescent with chronic renal failure: a case of Frasier syndrome. J Pediatr Adolesc Gynecol. 2002;15:145-9 pubmed
González Morán G, García Izquierdo J, Camacho Arroyo I. Progesterone receptor isoforms in ovary of newly-hatched chick after gonadotropin treatment during embryonic development. Comp Biochem Physiol A Mol Integr Physiol. 2002;132:519-26 pubmed
Akahira J, Inoue T, Suzuki T, Ito K, Konno R, Sato S, et al. Progesterone receptor isoforms A and B in human epithelial ovarian carcinoma: immunohistochemical and RT-PCR studies. Br J Cancer. 2000;83:1488-94 pubmed
product information
Product Type :
Antibody
Product Name :
Progesterone Receptor Monoclonal Antibody (hPRa 2)
Catalog # :
MA5-12642
Quantity :
500 µL
Price :
US 453.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human
Applications :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:100, Immunoprecipitation: 2 µg/mL, Western Blot: 1:50-1:100
Species :
Human
Clone :
hPRa 2
Isotype :
IgG1, kappa
Storage :
4° C
Description :
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
Immunogen :
PgR from a human endometrial carcinoma (EnCa 101) grown in athymic mice
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:100, Immunoprecipitation: 2 µg/mL, Western Blot: 1:50-1:100
Aliases :
9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA