Progesterone Receptor Monoclonal Antibody (PgR636) | Invitrogen MA5-12581 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Progesterone Receptor Monoclonal Antibody (PgR636)

catalog :

MA5-12581

quantity :

500 µL

price :

US 1048.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PgR636

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:50; loading ...	Carvajal Hausdorf D, Mani N, Velcheti V, Schalper K, Rimm D. Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer. J Immunother Cancer. 2017;5:81 pubmed publisher
immunohistochemistry - paraffin section; human	Coelho R, CalaÃ§a I, Celestrini D, Correia Carneiro A, Costa M, Zancan P, et al. Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma. Oncotarget. 2015;6:29375-87 pubmed publisher
immunohistochemistry; human; 1:1000	de Deus Moura R, Carvalho F, Bacchi C. Breast cancer in very young women: Clinicopathological study of 149 patients â‰¤25 years old. Breast. 2015;24:461-7 pubmed publisher
immunohistochemistry - paraffin section; human; 1:300	Tamega A, Miot H, MoÃ§o N, Silva M, Marques M, Miot L. Gene and protein expression of oestrogen-Î² and progesterone receptors in facial melasma and adjacent healthy skin in women. Int J Cosmet Sci. 2015;37:222-8 pubmed publisher
immunohistochemistry; mouse	Naidu R, Har Y, Taib N. Analysis of peptidyl-propyl-cis/trans isomerase 1 (PIN1) gene -842(G > C) and -667(T > C) polymorphic variants in relation to breast cancer risk and clinico-pathological parameters. Scand J Clin Lab Invest. 2011;71:500-6 pubmed publisher
immunohistochemistry; human	Christgen M, Christgen H, Heil C, Krech T, Langer F, Kreipe H, et al. Expression of KAI1/CD82 in distant metastases from estrogen receptor-negative breast cancer. Cancer Sci. 2009;100:1767-71 pubmed publisher
	Kim M, Chung Y, Kim H, Woo J, Ahn S, Park S. Immune microenvironment in ductal carcinoma in situ: a comparison with invasive carcinoma of the breast. Breast Cancer Res. 2020;22:32 pubmed publisher
	Jung Y, Kim H, Koo J. Expression of Lipid Metabolism-Related Proteins in Metastatic Breast Cancer. PLoS ONE. 2015;10:e0137204 pubmed publisher

image

image 1 :

Formalin-fixed, paraffin-embedded human breast cancer stained with PR antibody using peroxidase-conjugate and AEC chromogen. Note nuclear staining of tumor cells.

product information

Product Type :

Antibody

Product Name :

Progesterone Receptor Monoclonal Antibody (PgR636)

Catalog # :

MA5-12581

Quantity :

500 µL

Price :

US 1048.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:10-1:20, Western Blot: 1:500-1:1,000

Species :

Human

Clone :

PgR636

Isotype :

IgG1, kappa

Storage :

4° C

Description :

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.

Immunogen :

Formalin fixed recombinant full length A-form of human progesterone receptor

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:10-1:20, Western Blot: 1:500-1:1,000

Aliases :

9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product

more info or order :

Invitrogen product webpage