CD1a Monoclonal Antibody (O10) | Invitrogen MA5-12526 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD1a Monoclonal Antibody (O10)

catalog :

MA5-12526

quantity :

500 µL

price :

US 408.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

O10

reactivity :

human, rhesus macaque

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:50; loading ...	Li H, Shen P, Liang Y, Zhang F. Fibroblastic reticular cell tumor of the breast: A case report and review of the literature. Exp Ther Med. 2016;11:561-564 pubmed
immunohistochemistry - paraffin section; human; 1:25; loading ...; fig 2a	Kajimura J, Ito R, Manley N, Hale L. Optimization of Single- and Dual-Color Immunofluorescence Protocols for Formalin-Fixed, Paraffin-Embedded Archival Tissues. J Histochem Cytochem. 2016;64:112-24 pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig s1	Patyka M, Malamud D, Weissman D, Abrams W, Kurago Z. Periluminal Distribution of HIV-Binding Target Cells and Gp340 in the Oral, Cervical and Sigmoid/Rectal Mucosae: A Mapping Study. PLoS ONE. 2015;10:e0132942 pubmed publisher
immunohistochemistry; human; 1:50	Tan S, Yeo J, Kheem Pang B, Petersson F. An intraosseous sclerosing odontogenic tumor predominantly composed of epithelial cells: relation to (so-called) sclerosing odontogenic carcinoma and epithelial-rich central odontogenic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:e119-25 pubmed publisher
immunohistochemistry; human	Akdogan V, Yilmaz I, Canpolat T, Ozluoglu L. Role of Langerhans cells, Ki-67 protein and apoptosis in acquired cholesteatoma: prospective clinical study. J Laryngol Otol. 2013;127:252-9 pubmed publisher
immunocytochemistry; rhesus macaque	Tenbusch M, Ignatius R, Nchinda G, Trumpfheller C, Salazar A, Töpfer K, et al. Immunogenicity of DNA vaccines encoding simian immunodeficiency virus antigen targeted to dendritic cells in rhesus macaques. PLoS ONE. 2012;7:e39038 pubmed publisher
immunohistochemistry; human; 1:100	Hiraoka N, Yamazaki Itoh R, Ino Y, Mizuguchi Y, Yamada T, Hirohashi S, et al. CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis. Gastroenterology. 2011;140:310-21 pubmed publisher
immunohistochemistry; human	Mlecnik B, Tosolini M, Charoentong P, Kirilovsky A, Bindea G, Berger A, et al. Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer. Gastroenterology. 2010;138:1429-40 pubmed publisher
immunohistochemistry; human	Camus M, Tosolini M, Mlecnik B, Pages F, Kirilovsky A, Berger A, et al. Coordination of intratumoral immune reaction and human colorectal cancer recurrence. Cancer Res. 2009;69:2685-93 pubmed publisher
immunohistochemistry; human	Fadare O, Liang S. Epithelioid smooth muscle tumors of the uterus do not express CD1a: a potential immunohistochemical adjunct in their distinction from uterine perivascular epithelioid cell tumors. Ann Diagn Pathol. 2008;12:401-5 pubmed publisher
immunohistochemistry; human; 1:50	Cagigi A, Mowafi F, Phuong Dang L, Tenner Racz K, Atlas A, Grutzmeier S, et al. Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection. Blood. 2008;112:4401-10 pubmed publisher
immunocytochemistry; human; 1:20	Ito M, Minamiya Y, Kawai H, Saito S, Saito H, Nakagawa T, et al. Tumor-derived TGFbeta-1 induces dendritic cell apoptosis in the sentinel lymph node. J Immunol. 2006;176:5637-43 pubmed
	Pestronk A, Sinha N, Alhumayyd Z, Ly C, Schmidt R, Bucelli R. Immune myopathy with large histiocyte-related myofiber necrosis. Neurology. 2019;92:e1763-e1772 pubmed publisher

image

image 1 :

Formalin-fixed, paraffin-embedded human tonsil stained with CD1a antibody using peroxidase-conjugate and AEC chromogen. Note membrane staining of interdigitating cells of stratified squamous epithelium of tonsil.

product information

Product Type :

Antibody

Product Name :

CD1a Monoclonal Antibody (O10)

Catalog # :

MA5-12526

Quantity :

500 µL

Price :

US 408.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 2 µg/test, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:100-1:1,000

Species :

Human, Mouse

Clone :

O10

Isotype :

IgG1, kappa

Storage :

4° C

Description :

CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta 2 microglobulin. CD1a is expressed by cortical thymocytes, Langerhan's cells and by interdigitating cells. CD1a is also expressed by some malignancies of T cell lineage and in histiocytosis X. CD1a is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1a is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1a localizes to the plasma membrane and recycles vesicles of the early endocytic system. At least five CD1 genes (CD1a, b, c, d, and e) are identified. Alternatively spliced transcript variants of CD1a have been observed, but their biological validity have not been determined.

Immunogen :

Human thymus cells

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 2 µg/test, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:100-1:1,000

Aliases :

CD1; CD1 antigen; CD1.1; CD1A; CD1A antigen, a polypeptide; CD1a molecule; cd1a1; CD1A1 antigen; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; FCB6; HTA1; hTa1 thymocyte antigen; R4; T6; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a

more info or order :

Invitrogen product webpage