This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TOP2A Monoclonal Antibody (Ki-S1)
catalog :
MA5-12433
quantity :
500µL
price :
US 381
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Ki-S1
reactivity :
human
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
citations: 7
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; tbl 1
Gerber T, Willscher E, Loeffler Wirth H, Hopp L, Schadendorf D, Schartl M, et al. Mapping heterogeneity in patient-derived melanoma cultures by single-cell RNA-seq. Oncotarget. 2017;8:846-862 pubmed publisher
  • immunohistochemistry; human
El Rebey H, Aiad H, Abulkheir I, Asaad N, El Wahed M, Abulkasem F, et al. The Predictive and Prognostic Role of Topoisomerase IIα and Tissue Inhibitor of Metalloproteinases 1 Expression in Locally Advanced Breast Carcinoma of Egyptian Patients Treated With Anthracycline-based Neoadjuvant Chemotherapy. Appl Immunohistochem Mol Morphol. 2016;24:167-78 pubmed publisher
  • immunohistochemistry - paraffin section; human
Rusz O, Vörös A, Varga Z, Kelemen G, Uhercsák G, Nikolényi A, et al. One-Year Neoadjuvant Endocrine Therapy in Breast Cancer. Pathol Oncol Res. 2015;21:977-84 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400
Kiszner G, Wichmann B, Nemeth I, Varga E, Meggyeshazi N, Teleki I, et al. Cell cycle analysis can differentiate thin melanomas from dysplastic nevi and reveals accelerated replication in thick melanomas. Virchows Arch. 2014;464:603-12 pubmed publisher
  • immunohistochemistry; human
Nikolényi A, Sukosd F, Kaizer L, Csörgo E, Voros A, Uhercsak G, et al. Tumor topoisomerase II alpha status and response to anthracycline-based neoadjuvant chemotherapy in breast cancer. Oncology. 2011;80:269-77 pubmed publisher
  • immunohistochemistry; human; 1:200
Kärjä V, Sandell P, Kauppinen T, Alafuzoff I. Does protein expression predict recurrence of benign World Health Organization grade I meningioma?. Hum Pathol. 2010;41:199-207 pubmed publisher
Park S, Suh Y. Expression of cyclin A and topoisomerase IIalpha of oligodendrogliomas is correlated with tumour grade, MIB-1 labelling index and survival. Histopathology. 2003;42:395-402 pubmed
product information
Product Type :
Antibody
Product Name :
TOP2A Monoclonal Antibody (Ki-S1)
Catalog # :
MA5-12433
Quantity :
500µL
Price :
US 381
Clonality :
Monoclonal
Host :
Mouse
Reactivity :
Human
Applications :
Immunohistochemistry (Paraffin): 1:200-1:400, Western Blot: 1:500
Species :
Human
Clone :
Ki-S1
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cellsTopo II alpha is also implicated in drug resistance of tumor cells.
Immunogen :
Lysate of the human histiocytic leukemia cell line U937
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 1:200-1:400, Western Blot: 1:500
Aliases :
DNA gyrase, DNA topoisomerase (ATP-hydrolyzing), DNA topoisomerase 2-alpha, DNA topoisomerase II, 170 kD, DNA topoisomerase II, alpha isozyme, OTTHUMP00000207108
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA