| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; 1:1000; loading ...; fig 6a
- immunocytochemistry; human; 1:400; loading ...; fig 5b, 8
| Zhang S, Eitan E, Wu T, Mattson M. Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal. Neurobiol Aging. 2018;61:52-65 pubmed publisher |
- immunohistochemistry; human; 1:1000; loading ...; fig s2a
| Bengoa Vergniory N, Faggiani E, Ramos Gonzalez P, Kirkiz E, Connor Robson N, Brown L, et al. CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease. Nat Commun. 2020;11:4885 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4b
| Mazzulli J, Zunke F, Tsunemi T, Toker N, Jeon S, Burbulla L, et al. Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons. J Neurosci. 2016;36:7693-706 pubmed publisher |
- western blot; human; fig 2
| Caviness J, Lue L, Hentz J, Schmitz C, Adler C, Shill H, et al. Cortical phosphorylated α-Synuclein levels correlate with brain wave spectra in Parkinson's disease. Mov Disord. 2016;31:1012-9 pubmed publisher |
- immunohistochemistry; mouse; fig 1
| Kim C, Ojo Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, et al. Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease. J Neuroinflammation. 2015;12:236 pubmed publisher |
- immunocytochemistry; human
| Schwab A, Ebert A. Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. Stem Cell Reports. 2015;5:1039-1052 pubmed publisher |
- western blot; human; fig 4
| Spencer B, Valera E, Rockenstein E, Trejo Morales M, Adame A, Masliah E. A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy. Mol Neurodegener. 2015;10:48 pubmed publisher |
- immunohistochemistry; human; 1:1000; fig 1
| Bourdenx M, Dovero S, Engeln M, Bido S, Bastide M, Dutheil N, et al. Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression. Acta Neuropathol Commun. 2015;3:46 pubmed publisher |
- immunocytochemistry; human
| Taguchi K, Watanabe Y, Tsujimura A, Tatebe H, Miyata S, Tokuda T, et al. Differential expression of alpha-synuclein in hippocampal neurons. PLoS ONE. 2014;9:e89327 pubmed publisher |
- immunohistochemistry - free floating section; rat; 1:1000
| Reyes J, Rey N, Bousset L, Melki R, Brundin P, Angot E. Alpha-synuclein transfers from neurons to oligodendrocytes. Glia. 2014;62:387-98 pubmed publisher |
- western blot; human; 1:1000
| Chen R, Wislet Gendebien S, Samuel F, Visanji N, Zhang G, Marsilio D, et al. ?-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity. J Biol Chem. 2013;288:7438-49 pubmed publisher |
| Muntane G, Ferrer I, Martinez Vicente M. ?-synuclein phosphorylation and truncation are normal events in the adult human brain. Neuroscience. 2012;200:106-19 pubmed publisher |
- immunohistochemistry; human
| Verhagen M, Martin J, van Deuren M, Ceuterick de Groote C, Weemaes C, Kremer B, et al. Neuropathology in classical and variant ataxia-telangiectasia. Neuropathology. 2012;32:234-44 pubmed publisher |
| Rieker C, Dev K, Lehnhoff K, Barbieri S, Ksiazek I, Kauffmann S, et al. Neuropathology in mice expressing mouse alpha-synuclein. PLoS ONE. 2011;6:e24834 pubmed publisher |
- immunocytochemistry; mouse; 1:1000; fig 2
| Feng L, Federoff H, Vicini S, Maguire Zeiss K. Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability. Eur J Neurosci. 2010;32:10-7 pubmed publisher |
- immunohistochemistry; human; 1:50
| Holm I, Englund E, Mackenzie I, Johannsen P, Isaacs A. A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3. J Neuropathol Exp Neurol. 2007;66:884-91 pubmed |
- western blot; human; 1:1000
| Dalfo E, Martinez A, Muntane G, Ferrer I. Abnormal alpha-synuclein solubility, aggregation and nitration in the frontal cortex in Pick's disease. Neurosci Lett. 2006;400:125-9 pubmed |
| Choong C, Aguirre C, Kakuda K, Beck G, Nakanishi H, Kimura Y, et al. Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism. Acta Neuropathol. 2023;145:573-595 pubmed publisher |
| Yuan X, Yang Y, Liu C, Tian Y, Xia D, Liu Z, et al. Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration. Mov Disord. 2022;37:1817-1830 pubmed publisher |
| Abdul Sisak M, Louis F, Miyao T, Lee S, Chang Y, Matsusaki M. Mechanism assay of interaction between blood vessels-near infrared probe and cell surface marker proteins of endothelial cells. Mater Today Bio. 2022;15:100332 pubmed publisher |
| Cai W, Srivastava P, Feng D, Lin Y, Vanderburg C, Xu Y, et al. Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease. Mol Neurodegener. 2022;17:16 pubmed publisher |
| Yan M, Xiong M, Dai L, Zhang X, Zha Y, Deng X, et al. Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson's disease. NPJ Parkinsons Dis. 2022;8:1 pubmed publisher |
| Gao Q, Chen R, Wu L, Huang Q, Wang X, Tian Y, et al. Angiotensin-(1-7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson's disease. Neural Regen Res. 2022;17:1138-1145 pubmed publisher |
| Vogiatzis S, Celestino M, Trevisan M, Magro G, Del Vecchio C, Erdengiz D, et al. Lentiviral Vectors Expressing Chimeric NEDD4 Ubiquitin Ligases: An Innovative Approach for Interfering with Alpha-Synuclein Accumulation. Cells. 2021;10: pubmed publisher |
| Bogale T, Faustini G, Longhena F, Mitola S, Pizzi M, Bellucci A. Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives. Front Immunol. 2021;12:611761 pubmed publisher |
| Ma Z, Liu K, Li X, Wang C, Liu C, Yan D, et al. Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors. Cell Death Dis. 2020;11:834 pubmed publisher |
| Murakami H, Tokuda T, El Agnaf O, Ohmichi T, Miki A, Ohashi H, et al. Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson's disease. BMC Neurol. 2019;19:113 pubmed publisher |
| Harischandra D, Rokad D, Neal M, Ghaisas S, Manne S, Sarkar S, et al. Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein. Sci Signal. 2019;12: pubmed publisher |
| Li X, Koudstaal W, Fletcher L, Costa M, Van Winsen M, Siregar B, et al. Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology. Acta Neuropathol. 2019;137:825-836 pubmed publisher |
| Longhena F, Faustini G, Missale C, Pizzi M, Bellucci A. Dopamine Transporter/?-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson's Disease: An In Situ Proximity Ligation Assay Study. Int J Mol Sci. 2018;19: pubmed publisher |
| Henrich M, Geibl F, Lee B, Chiu W, Koprich J, Brotchie J, et al. A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. Acta Neuropathol Commun. 2018;6:39 pubmed publisher |
| Recasens A, Carballo Carbajal I, Parent A, Bove J, Gelpi E, Tolosa E, et al. Lack of pathogenic potential of peripheral ?-synuclein aggregates from Parkinson's disease patients. Acta Neuropathol Commun. 2018;6:8 pubmed publisher |
| Zunke F, Moise A, Belur N, Gelyana E, Stojkovska I, Dzaferbegovic H, et al. Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide. Neuron. 2018;97:92-107.e10 pubmed publisher |
| Rockenstein E, Ostroff G, Dikengil F, Rus F, Mante M, Florio J, et al. Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies. J Neurosci. 2018;38:1000-1014 pubmed publisher |
| Spencer B, Valera E, Rockenstein E, OVERK C, Mante M, Adame A, et al. Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathol Commun. 2017;5:7 pubmed publisher |
| Shi M, Bradner J, Bammler T, Eaton D, Zhang J, Ye Z, et al. Identification of glutathione S-transferase pi as a protein involved in Parkinson disease progression. Am J Pathol. 2009;175:54-65 pubmed publisher |
