14-3-3 Pan Monoclonal Antibody (CG15) | Invitrogen MA5-12242 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

14-3-3 Pan Monoclonal Antibody (CG15)

catalog :

MA5-12242

quantity :

500 µL

price :

US 450.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CG15

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; mouse	Cam M, Bid H, Xiao L, Zambetti G, Houghton P, Cam H. p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage. J Biol Chem. 2014;289:4083-94 pubmed publisher
immunoprecipitation; mouse western blot; mouse; 1:1000	Vadysirisack D, Ellisen L. mTOR activity under hypoxia. Methods Mol Biol. 2012;821:45-58 pubmed publisher
western blot; human	Mashukova A, Oriolo A, Wald F, Casanova M, Kröger C, Magin T, et al. Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones. J Cell Sci. 2009;122:2491-503 pubmed publisher
western blot; human	Tomassi L, Costantini A, Corallino S, Santonico E, Carducci M, Cesareni G, et al. The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins. BMC Biochem. 2008;9:21 pubmed publisher
immunoprecipitation; mouse	DeYoung M, Horak P, Sofer A, Sgroi D, Ellisen L. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev. 2008;22:239-51 pubmed publisher
immunoprecipitation; human western blot; human	Liu H, Radisky D, Nelson C, Zhang H, Fata J, Roth R, et al. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A. 2006;103:4134-9 pubmed
	Britto F, Begue G, Rossano B, Docquier A, Vernus B, Sar C, et al. REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy. Am J Physiol Endocrinol Metab. 2014;307:E983-93 pubmed publisher

product information

Product Type :

Antibody

Product Name :

14-3-3 Pan Monoclonal Antibody (CG15)

Catalog # :

MA5-12242

Quantity :

500 µL

Price :

US 450.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL

Species :

Human, Mouse

Clone :

CG15

Isotype :

IgG1, kappa

Storage :

4° C

Description :

At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and, through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.

Immunogen :

14-3-3 gamma recombinant human protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL

Aliases :

1110013I11Rik; 1300003C17Rik; 14-3-3; 14-3-3 alpha; 14-3-3 beta; 14-3-3 delta; 14-3-3 epsilon; 14-3-3 gamma; 14-3-3 protein beta; 14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha, N-terminally processed; 14-3-3 protein beta/alpha-A; 14-3-3 protein beta/alpha-B; 14-3-3 protein beta-subtype; 14-3-3 protein epsilon; 14-3-3 protein gamma; 14-3-3 protein gamma subtype; 14-3-3 protein gamma, N-terminally processed; 14-3-3 protein gamma-A; 14-3-3 protein gamma-B; 14-3-3 protein gamma-subtype; 14-3-3 protein sigma; 14-3-3 protein tau; 14-3-3 protein T-cell; 14-3-3 protein theta; 14-3-3 protein zeta; 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 sigma; 14-3-3 sigma protein; 14-3-3 tau; 14-3-3 theta; 14-3-3 zeta; 14-3-3beta; 14-3-3d; 14-3-3E; 14-3-3G; 14-3-3gamma; 14-3-3-like protein; 14-3-3t; 14-3-3z; 14-3-3zeta; 14-3-3-zeta; 1C5; 2700028P07Rik; 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; 3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; AA409740; AI596267; AL022924; AU019196; AU020854; AU021156; brain protein 14-3-3, beta isoform; D7Bwg1348e; epididymis luminal protein 2; epididymis luminal protein 4; epididymis secretory protein Li 1; epididymis secretory protein Li 3; epididymis secretory protein Li 93; epithelial cell marker protein 1; Er; factor activating exoenzyme S; FAS; GW128; HEL2; HEL4; HEL-S-1; HEL-S-3; HEL-S-93; HME1; HS1; KCIP-1; MDCR; MDS; mitochondrial import stimulation factor (MSF) L subunit; mitochondrial import stimulation factor L subunit; Mitochondrial import stimulation factor S1 subunit; Mkrn3; Mme1; MSF L; Msfs1; phospholipase A2; PPP1R170; prepronerve growth factor RNH-1; Protein 1054; Protein HS1; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; protein phosphatase 1, regulatory subunit 170; protein tau; protein, theta; R74690; SEZ-2; SFN; Stratifin; tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma; tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta L homeolog; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta S homeolog; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma L homeolog; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma S homeolog