| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry; mouse; loading ...; fig 5a
| Zhang Y, Mao D, Keeler S, Wang X, Wu K, Gerovac B, et al. Respiratory Enterovirus (Like Parainfluenza Virus) Can Cause Chronic Lung Disease If Protection by Airway Epithelial STAT1 Is Lost. J Immunol. 2019;: pubmed publisher |
- immunocytochemistry; human
| Hild M, Jaffe A. Production of 3-D Airway Organoids From Primary Human Airway Basal Cells and Their Use in High-Throughput Screening. Curr Protoc Stem Cell Biol. 2016;37:IE.9.1-IE.9.15 pubmed publisher |
| Tokita E, Tanabe T, Asano K, Suzaki H, Rubin B. Club cell 10-kDa protein attenuates airway mucus hypersecretion and inflammation. Eur Respir J. 2014;44:1002-10 pubmed publisher |
- flow cytometry; human; 200 ug/ml
| Montalbano A, Albano G, Anzalone G, Bonanno A, Riccobono L, Di Sano C, et al. Cigarette smoke alters non-neuronal cholinergic system components inducing MUC5AC production in the H292 cell line. Eur J Pharmacol. 2014;736:35-43 pubmed publisher |
| Sikder M, Lee H, Ryu J, Park S, Kim J, Hong J, et al. Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells. Tuberc Respir Dis (Seoul). 2014;76:120-6 pubmed publisher |
| Lee H, Ryu J, Park S, Seo E, Han A, Lee S, et al. Suppressive effects of coixol, glyceryl trilinoleate and natural products derived from Coix Lachryma-Jobi var. ma-yuen on gene expression, production and secretion of airway MUC5AC mucin. Arch Pharm Res. 2015;38:620-7 pubmed publisher |
- immunohistochemistry; mouse; 1:200
| von Figura G, Fukuda A, Roy N, Liku M, Morris Iv J, Kim G, et al. The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol. 2014;16:255-67 pubmed publisher |
| Poachanukoon O, Koontongkaew S, Monthanapisut P, Pattanacharoenchai N. Macrolides attenuate phorbol ester-induced tumor necrosis factor-? and mucin production from human airway epithelial cells. Pharmacology. 2014;93:92-9 pubmed publisher |
| Ryu J, Lee H, Park S, Sikder M, Kim J, Hong J, et al. Effect of Prunetin on TNF-?-Induced MUC5AC Mucin Gene Expression, Production, Degradation of I?B and Translocation of NF-?B p65 in Human Airway Epithelial Cells. Tuberc Respir Dis (Seoul). 2013;75:205-9 pubmed publisher |
| Wagner J, Birmingham N, Jackson Humbles D, Jiang Q, Harkema J, Peden D. Supplementation with ?-tocopherol attenuates endotoxin-induced airway neutrophil and mucous cell responses in rats. Free Radic Biol Med. 2014;68:101-9 pubmed publisher |
| Ryu J, Lee H, Park S, Kim J, Lee D, Lee S, et al. Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D(3) and deapi-platycodin on production and secretion of airway mucin in vitro. Phytomedicine. 2014;21:529-33 pubmed publisher |
- immunohistochemistry; human; 1:100
| Gundavarapu S, Mishra N, Singh S, Langley R, Saeed A, Feghali Bostwick C, et al. HIV gp120 induces mucus formation in human bronchial epithelial cells through CXCR4/α7-nicotinic acetylcholine receptors. PLoS ONE. 2013;8:e77160 pubmed publisher |
- immunocytochemistry; human
| Strengert M, Jennings R, Davanture S, Hayes P, Gabriel G, Knaus U. Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection. Antioxid Redox Signal. 2014;20:2695-709 pubmed publisher |
| Park S, Lee H, Ryu J, Son K, Kwon S, Lee S, et al. Effects of ophiopogonin D and spicatoside A derived from Liriope Tuber on secretion and production of mucin from airway epithelial cells. Phytomedicine. 2014;21:172-6 pubmed publisher |
- immunohistochemistry; human; 1:100
| Warneke V, Behrens H, Haag J, Kruger S, Simon E, Mathiak M, et al. Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis. Br J Cancer. 2013;109:2217-27 pubmed publisher |
- immunohistochemistry; human; 1:500
| Futtrup T, Hasselby J, Baeksgaard L. Gastric signet ring cell carcinoma presenting as diffuse, infiltrating myositis--a case report and review of the literature. J Gastrointest Cancer. 2014;45 Suppl 1:62-5 pubmed publisher |
| Traub S, Nikonova A, Carruthers A, Dunmore R, Vousden K, Gogsadze L, et al. An anti-human ICAM-1 antibody inhibits rhinovirus-induced exacerbations of lung inflammation. PLoS Pathog. 2013;9:e1003520 pubmed publisher |
| Liu C, Li Q, Zhou X, Kolosov V, Perelman J. Rhythmic pressure waves induce mucin5AC expression via an EGFR-mediated signaling pathway in human airway epithelial cells. DNA Cell Biol. 2013;32:423-9 pubmed publisher |
| Cho H, Gladwell W, Yamamoto M, Kleeberger S. Exacerbated airway toxicity of environmental oxidant ozone in mice deficient in Nrf2. Oxid Med Cell Longev. 2013;2013:254069 pubmed publisher |
- immunocytochemistry; human; 1:100
- western blot; human; 1:1000
| Mitrovic S, Nogueira C, Cantero Recasens G, Kiefer K, Fernández Fernández J, Popoff J, et al. TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells. elife. 2013;2:e00658 pubmed publisher |
- western blot; pigs ; 1:500
| Bartlett J, Albertolle M, Wohlford Lenane C, Pezzulo A, Zabner J, Niles R, et al. Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs. Am J Physiol Lung Cell Mol Physiol. 2013;305:L256-66 pubmed publisher |
- immunohistochemistry; human; 1:2000
| Park H, Lee S, Hong S, Kim J, Sung I, Park H, et al. Early Gastric Cancer-Like Advanced Gastric Cancer versus Advanced Gastric Cancer-Like Early Gastric Cancer. Clin Endosc. 2013;46:155-60 pubmed publisher |
- immunohistochemistry; mouse; 1:1
| Park J, Sharif A, Shiomi T, Kobzik L, Kasahara D, Tschumperlin D, et al. Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2013;304:L701-7 pubmed publisher |
- immunohistochemistry; human; 1:500
| Seibold M, Smith R, Urbanek C, Groshong S, Cosgrove G, Brown K, et al. The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium. PLoS ONE. 2013;8:e58658 pubmed publisher |
- immunocytochemistry; human
| Sesma J, Kreda S, Okada S, van Heusden C, Moussa L, Jones L, et al. Vesicular nucleotide transporter regulates the nucleotide content in airway epithelial mucin granules. Am J Physiol Cell Physiol. 2013;304:C976-84 pubmed publisher |
| Sikder M, Lee H, Mia M, Park S, Ryu J, Kim J, et al. Inhibition of TNF-?-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells. Phytother Res. 2014;28:62-8 pubmed publisher |
- immunohistochemistry; rat; 1:200
| An J, Li J, Wang T, Li X, Guo L, Wan C, et al. Blocking of thromboxane A? receptor attenuates airway mucus hyperproduction induced by cigarette smoke. Eur J Pharmacol. 2013;703:11-7 pubmed publisher |
- immunohistochemistry; human; 1:750
| Walsh M, Cummings M, Pearson S, Clendenning M, Walters R, Nagler B, et al. Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins. Mod Pathol. 2013;26:944-54 pubmed publisher |
- immunohistochemistry; mouse; 1:200
| Mushaben E, Brandt E, Hershey G, Le Cras T. Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma. PLoS ONE. 2013;8:e54426 pubmed publisher |
- immunohistochemistry; mouse
| Floyd A, Zhou X, Evans C, Rompala O, Zhu L, Wang M, et al. Mucin deficiency causes functional and structural changes of the ocular surface. PLoS ONE. 2012;7:e50704 pubmed publisher |
| Harrop C, Gore R, Evans C, Thornton D, Herrick S. TGF-?? decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells. Exp Lung Res. 2013;39:39-47 pubmed publisher |
| Shin H, Lee H, Sikder M, Park S, Ryu J, Hong J, et al. Effect of Chrysin on Gene Expression and Production of MUC5AC Mucin from Cultured Airway Epithelial Cells. Tuberc Respir Dis (Seoul). 2012;73:204-9 pubmed publisher |
| Seagrave J, Albrecht H, Hill D, Rogers D, Solomon G. Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells. Respir Res. 2012;13:98 pubmed publisher |
| Liu C, Li Q, Zhou X, Kolosov V, Perelman J. Regulator of G-protein signaling 2 inhibits acid-induced mucin5AC hypersecretion in human airway epithelial cells. Respir Physiol Neurobiol. 2013;185:265-71 pubmed publisher |
- immunohistochemistry; mouse
| Syu L, El Zaatari M, Eaton K, Liu Z, Tetarbe M, Keeley T, et al. Transgenic expression of interferon-? in mouse stomach leads to inflammation, metaplasia, and dysplasia. Am J Pathol. 2012;181:2114-25 pubmed publisher |
- immunohistochemistry; rat; 1:100
| Fostad I, Eidet J, Shatos M, Utheim T, Utheim O, Raeder S, et al. Biopsy harvesting site and distance from the explant affect conjunctival epithelial phenotype ex vivo. Exp Eye Res. 2012;104:15-25 pubmed publisher |
- immunocytochemistry; human
| de Courcey F, Zholos A, Atherton Watson H, Williams M, Canning P, Danahay H, et al. Development of primary human nasal epithelial cell cultures for the study of cystic fibrosis pathophysiology. Am J Physiol Cell Physiol. 2012;303:C1173-9 pubmed publisher |
- immunohistochemistry; human; 1:2000
| Lee H, Lee S, Yoon H, Hong S, Kim J, Sung I, et al. Change of mucosal color in early gastric cancer. J Dig Dis. 2012;13:510-6 pubmed publisher |
- immunohistochemistry; human; 1:1000
- immunocytochemistry; mouse; 1:200
| Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters C, et al. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012;109:16354-9 pubmed publisher |
- immunohistochemistry; human; 1:100
| Song J, Kim B, Lee A, Lee K, Chung I, Lee B, et al. Expression of MUC5AC and Trefoil Peptide 1 (TFF1) in the Subtypes of Intestinal Metaplasia. Clin Endosc. 2012;45:151-4 pubmed publisher |
| Yu H, Li Q, Kolosov V, Perelman J, Zhou X. Regulation of particulate matter-induced mucin secretion by transient receptor potential vanilloid 1 receptors. Inflammation. 2012;35:1851-9 pubmed publisher |
- flow cytometry; mouse; 1:100
- immunocytochemistry; human; 1:500
| Val S, Belade E, George I, Boczkowski J, Baeza Squiban A. Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin. Arch Toxicol. 2012;86:1851-9 pubmed publisher |
| Wagner J, Morishita M, Keeler G, Harkema J. Divergent effects of urban particulate air pollution on allergic airway responses in experimental asthma: a comparison of field exposure studies. Environ Health. 2012;11:45 pubmed publisher |
| Ben Mohamed F, Mohamed F, Garcia Verdugo I, Medina M, Balloy V, Chignard M, et al. A crucial role of Flagellin in the induction of airway mucus production by Pseudomonas aeruginosa. PLoS ONE. 2012;7:e39888 pubmed publisher |
- immunohistochemistry; mouse; 1:200
| Kang I, Jung J, Kim S. Asian sand dust enhances allergen-induced th2 allergic inflammatory changes and mucin production in BALB/c mouse lungs. Allergy Asthma Immunol Res. 2012;4:206-13 pubmed publisher |
- immunohistochemistry; human
| Iwashita H, Fujimoto K, Morita S, Nakanishi A, Kubo K. Increased human Ca²?-activated Cl? channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients. Respir Res. 2012;13:55 pubmed publisher |
- immunohistochemistry; human; 1:100
| Kang H, An H, Song J, Kim T, Heo J, Ahn D, et al. Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression. Histopathology. 2012;61:576-86 pubmed publisher |
| Han S, Howatt D, Daugherty A, Gairola C. Atherogenic and pulmonary responses of ApoE- and LDL receptor-deficient mice to sidestream cigarette smoke. Toxicology. 2012;299:133-8 pubmed publisher |
- immunohistochemistry; mouse
| Lee J, Komatsu K, Lee B, Lim J, Jono H, Xu H, et al. Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway. J Biol Chem. 2012;287:22799-811 pubmed publisher |
- immunohistochemistry; human
| Gundavarapu S, Wilder J, Mishra N, Rir Sima Ah J, Langley R, Singh S, et al. Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo. J Allergy Clin Immunol. 2012;130:770-780.e11 pubmed publisher |
| Yu H, Li Q, Zhou X, Kolosov V, Perelman J. Transient receptor potential vanilloid 1 receptors mediate acid-induced mucin secretion via Ca2+ influx in human airway epithelial cells. J Biochem Mol Toxicol. 2012;26:179-86 pubmed publisher |
| Wang X, Li Q, Zhou X, Kolosov V, Perelman J. Triiodothyronine represses MUC5AC expression by antagonizing Sp1 binding to its promoter in human bronchial epithelial HBE16 cells. J Biomed Biotechnol. 2012;2012:648170 pubmed publisher |
- immunohistochemistry; mouse; 1:100
| Vincent D, Gout J, Chuvin N, Arfi V, Pommier R, Bertolino P, et al. Tif1? suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway. Am J Pathol. 2012;180:2214-21 pubmed publisher |
- immunohistochemistry; rat; 1:200
- western blot; rat; 1:1000
| Yang T, Luo F, Shen Y, An J, Li X, Liu X, et al. Quercetin attenuates airway inflammation and mucus production induced by cigarette smoke in rats. Int Immunopharmacol. 2012;13:73-81 pubmed publisher |
- immunohistochemistry; mouse; 1:100
- western blot; mouse
| Jang S, Park J, Cha H, Jung S, Lee J, Jung S, et al. Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation. Int J Nanomedicine. 2012;7:1329-43 pubmed publisher |
- immunohistochemistry; mouse; 1:200
| Hashimoto S, Chen H, Que J, Brockway B, Drake J, Snyder J, et al. ?-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. J Cell Sci. 2012;125:932-42 pubmed publisher |
| Kim J, Sikder M, Lee H, Rahman M, Kim J, Chang G, et al. Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin. Phytother Res. 2012;26:1784-8 pubmed publisher |
| Jiang D, Li Q, Kolosov V, Zhou X. The inhibition of aldose reductase on mucus production induced by interleukin-13 in the human bronchial epithelial cells. Int Immunopharmacol. 2012;12:588-93 pubmed publisher |
| Dahl R, Titlestad I, Lindqvist A, Wielders P, Wray H, Wang M, et al. Effects of an oral MMP-9 and -12 inhibitor, AZD1236, on biomarkers in moderate/severe COPD: a randomised controlled trial. Pulm Pharmacol Ther. 2012;25:169-77 pubmed publisher |
| Kim K, Lee H, Lim S, Sikder A, Lee S, Lee C. Silibinin regulates gene expression, production and secretion of mucin from cultured airway epithelial cells. Phytother Res. 2012;26:1301-7 pubmed publisher |
- immunocytochemistry; human
- ELISA; human; 1:100
| Yu H, Zhou X, Wen S, Xiao Q. Flagellin/TLR5 responses induce mucus hypersecretion by activating EGFR via an epithelial cell signaling cascades. Exp Cell Res. 2012;318:723-31 pubmed publisher |
| Lee S, Lee H, Sikder M, Shin H, Kim J, Chang G, et al. Resveratrol inhibits mucin gene expression, production and secretion from airway epithelial cells. Phytother Res. 2012;26:1082-7 pubmed publisher |
- immunocytochemistry; human; 1:50
| Wu Q, Jiang D, Chu H. Cigarette smoke induces growth differentiation factor 15 production in human lung epithelial cells: implication in mucin over-expression. Innate Immun. 2012;18:617-26 pubmed publisher |
- immunohistochemistry; human; 1:100
| Kim B. Regional conjunctivectomy with postoperative mitomycin C to treat chronic hyperemic conjunctiva. Cornea. 2012;31:236-44 pubmed publisher |
- immunohistochemistry; human
- ELISA; human
| Kanoh S, Tanabe T, Rubin B. IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells. Clin Exp Allergy. 2011;41:1747-56 pubmed publisher |
| Seagrave J, Albrecht H, Park Y, Rubin B, Solomon G, Kim K. Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells. Exp Lung Res. 2011;37:606-14 pubmed publisher |
- immunohistochemistry; mouse; 1:100
| Wang S, Xiang Y, Ellis R, Wattie J, Feng M, Inman M, et al. Effects of furosemide on allergic asthmatic responses in mice. Clin Exp Allergy. 2011;41:1456-67 pubmed publisher |
- immunohistochemistry; human; 2 ug/ml
| Joo J, Ryu J, Kim C, Kim H, Suh M, Kim J, et al. Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa. Antioxid Redox Signal. 2012;16:57-70 pubmed publisher |
| Li N, Li Q, Zhou X, Kolosov V, Perelman J. Chronic mechanical stress induces mucin 5AC expression in human bronchial epithelial cells through ERK dependent pathways. Mol Biol Rep. 2012;39:1019-28 pubmed publisher |
- immunocytochemistry; human
- ELISA; human; 1:100
| Yu H, Li Q, Kolosov V, Perelman J, Zhou X. Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1? via epidermal growth factor receptor-mediated signaling pathways. J Appl Toxicol. 2012;32:282-92 pubmed publisher |
| Yageta Y, Ishii Y, Morishima Y, Masuko H, Ano S, Yamadori T, et al. Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice. J Virol. 2011;85:4679-90 pubmed publisher |
- immunohistochemistry; human; 1:100
| Ilhan O, Han U, Onal B, Çelık S. Prognostic significance of MUC1, MUC2 and MUC5AC expressions in gastric carcinoma. Turk J Gastroenterol. 2010;21:345-52 pubmed |
| Ma B, Dela Cruz C, Hartl D, Kang M, Takyar S, Homer R, et al. RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism. Am J Respir Crit Care Med. 2011;183:1322-35 pubmed publisher |
- immunohistochemistry; mouse
| Sivaprasad U, Askew D, Ericksen M, Gibson A, Stier M, Brandt E, et al. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011;127:254-61, 261.e1-6 pubmed publisher |
- immunocytochemistry; human; 1:200
- ELISA; human; 1:500
| Li Q, Zhou X, Kolosov V, Perelman J. Nicotine suppresses inflammatory factors in HBE16 airway epithelial cells after exposure to cigarette smoke extract and lipopolysaccharide. Transl Res. 2010;156:326-34 pubmed publisher |
- immunohistochemistry; human; 1:2000
| Kuroda N, Onishi K, Lee G. Combined tubular adenocarcinoma and hepatoid adenocarcinoma arising in Barrett esophagus. Ann Diagn Pathol. 2011;15:450-3 pubmed publisher |
| Kerschner J, Tripathi S, Khampang P, Papsin B. MUC5AC expression in human middle ear epithelium of patients with otitis media. Arch Otolaryngol Head Neck Surg. 2010;136:819-24 pubmed publisher |
- immunohistochemistry; mouse
| Hata S, Abe M, Suzuki H, Kitamura F, Toyama Sorimachi N, Abe K, et al. Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. PLoS Genet. 2010;6:e1001040 pubmed publisher |
- immunohistochemistry; mouse; 1:200
| Narumoto O, Horiguchi K, Horiguchi S, Moriwaki Y, Takano Ohmuro H, Shoji S, et al. Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric alpha7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions. Biochem Biophys Res Commun. 2010;398:713-8 pubmed publisher |
- immunohistochemistry; human; 1:100
- immunohistochemistry; mouse; 1:25
| Mavanur A, Parimi V, O Malley M, Nikiforova M, Bartlett D, Davison J. Establishment and characterization of a murine xenograft model of appendiceal mucinous adenocarcinoma. Int J Exp Pathol. 2010;91:357-67 pubmed publisher |
- immunohistochemistry; mouse
| Shen Y, Wang Y, Chen Z, Wang D, Wang X, Jin M, et al. Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice. J Cell Mol Med. 2011;15:1355-63 pubmed publisher |
- immunohistochemistry; human; 1:100
- ELISA; human; 1:100
- western blot; human
| Cortijo J, Mata M, Milara J, Donet E, Gavalda A, Miralpeix M, et al. Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways. Eur Respir J. 2011;37:244-54 pubmed publisher |
| Woo H, Yoo W, Bae C, Song S, Kim Y, Park S, et al. Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway. Exp Lung Res. 2010;36:262-9 pubmed publisher |
- immunohistochemistry; mouse; 1:100
- western blot; human
| Nishimoto Y, Hisatsune A, Katsuki H, Miyata T, Yokomizo K, Isohama Y. Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro. J Pharmacol Sci. 2010;113:76-83 pubmed |
- immunocytochemistry; human
- western blot; human
| Kreda S, Seminario Vidal L, van Heusden C, O NEAL W, Jones L, Boucher R, et al. Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides. J Physiol. 2010;588:2255-67 pubmed publisher |
- immunohistochemistry; mouse
- ELISA; mouse
| Dif F, Wu Y, Burgel P, Ollero M, Leduc D, Aarbiou J, et al. Critical role of cytosolic phospholipase A2{alpha} in bronchial mucus hypersecretion in CFTR-deficient mice. Eur Respir J. 2010;36:1120-30 pubmed publisher |
- immunohistochemistry; rat; 1:200
| Chen Y, Chen P, Wang H, Wang T, Chen L, Wang X, et al. Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway. Int Immunopharmacol. 2010;10:685-93 pubmed publisher |
- immunohistochemistry; human; 1:100
| Flatmark K, Davidson B, Kristian A, Stavnes H, Førsund M, Reed W. Exploring the peritoneal surface malignancy phenotype--a pilot immunohistochemical study of human pseudomyxoma peritonei and derived animal models. Hum Pathol. 2010;41:1109-19 pubmed publisher |
- immunohistochemistry; human; 1:100
| Balci S, Saglam A, Usubutun A. Primary signet-ring cell carcinoma of the cervix: case report and review of the literature. Int J Gynecol Pathol. 2010;29:181-4 pubmed publisher |
| Han S, Andrews R, Gairola C. Acute pulmonary response of mice to multi-wall carbon nanotubes. Inhal Toxicol. 2010;22:340-7 pubmed publisher |
- flow cytometry; human; 10 ug/ml
- immunocytochemistry; human; 1:100
| Haswell L, Hewitt K, Thorne D, Richter A, Gaça M. Cigarette smoke total particulate matter increases mucous secreting cell numbers in vitro: a potential model of goblet cell hyperplasia. Toxicol In Vitro. 2010;24:981-7 pubmed publisher |
- immunocytochemistry; human; 1:100
- immunohistochemistry; mouse; 1:100
| Kono Y, Nishiuma T, Okada T, Kobayashi K, Funada Y, Kotani Y, et al. Sphingosine kinase 1 regulates mucin production via ERK phosphorylation. Pulm Pharmacol Ther. 2010;23:36-42 pubmed publisher |
| Aguilera Aguirre L, Bacsi A, Saavedra Molina A, Kurosky A, Sur S, Boldogh I. Mitochondrial dysfunction increases allergic airway inflammation. J Immunol. 2009;183:5379-87 pubmed publisher |
- immunohistochemistry; mouse; 1:100
| Tachdjian R, Mathias C, Al Khatib S, Bryce P, Kim H, Blaeser F, et al. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. J Exp Med. 2009;206:2191-204 pubmed publisher |
- western blot; human; 1:200
| Cho J, Woo J, Lee H, Jung H, Hwang S, Chae S. Effects of cigarette smoking on mucin production in human middle ear epithelial cells. Int J Pediatr Otorhinolaryngol. 2009;73:1447-51 pubmed publisher |
- immunohistochemistry; chicken; 1:100
| Sagsoz H, Liman N. Structure of the oesophagus and morphometric, histochemical-immunohistochemical profiles of the oesophageal gland during the post-hatching period of Japanese quails (Coturnix coturnix japonica). Anat Histol Embryol. 2009;38:330-40 pubmed publisher |
- immunohistochemistry; pigs ; 1:50
| Goel S, Fujihara M, Tsuchiya K, Takagi Y, Minami N, Yamada M, et al. Multipotential ability of primitive germ cells from neonatal pig testis cultured in vitro. Reprod Fertil Dev. 2009;21:696-708 pubmed publisher |
- immunocytochemistry; human
| Luxen S, Noack D, Frausto M, Davanture S, Torbett B, Knaus U. Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. J Cell Sci. 2009;122:1238-47 pubmed publisher |
- immunohistochemistry; human
| Sartori G, Cavazza A, Sgambato A, Marchioni A, Barbieri F, Longo L, et al. EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors. Am J Clin Pathol. 2009;131:478-89 pubmed publisher |
| Heo H, Lee S, Lee M, Lee H, Seok J, Lee C. Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells. Phytother Res. 2009;23:1458-61 pubmed publisher |
- blocking or activating experiments; human
| Shinagawa K, Ploplis V, Castellino F. A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice. Am J Physiol Lung Cell Mol Physiol. 2009;296:L763-70 pubmed publisher |
- immunohistochemistry; human
| Tong L, Chew J, Yang H, Ang L, Tan D, Beuerman R. Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide expression data. BMC Med Genomics. 2009;2:14 pubmed publisher |
- flow cytometry; human; 1:250
- western blot; human
| Chung W, Ryu S, Sun H, Zeldin D, Koo J. CREB mediates prostaglandin F2alpha-induced MUC5AC overexpression. J Immunol. 2009;182:2349-56 pubmed publisher |
| Song K, Choi Y, Kim J, Lee H, Lee T, Yoon J. Suppression of prostaglandin E2-induced MUC5AC overproduction by RGS4 in the airway. Am J Physiol Lung Cell Mol Physiol. 2009;296:L684-92 pubmed publisher |
- immunohistochemistry; human; 1:2000
| Han H, Lee S, Lee K, Hong S, Kim J, Sung I, et al. Unclassified mucin phenotype of gastric adenocarcinoma exhibits the highest invasiveness. J Gastroenterol Hepatol. 2009;24:658-66 pubmed publisher |
- immunocytochemistry; human; 1:500
- western blot; human; 1:500
| Park J, Tschumperlin D. Chronic intermittent mechanical stress increases MUC5AC protein expression. Am J Respir Cell Mol Biol. 2009;41:459-66 pubmed publisher |
| Cortijo J, Iranzo A, Milara X, Mata M, Cerda Nicolas M, Ruiz Sauri A, et al. Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury. Br J Pharmacol. 2009;156:534-44 pubmed publisher |
- immunocytochemistry; human; 1:1000
| Jiang J, Malavia N, Suresh V, George S. Nitric oxide gas phase release in human small airway epithelial cells. Respir Res. 2009;10:3 pubmed publisher |
- immunohistochemistry; rat
| Wang T, Liu Y, Chen L, Wang X, Hu X, Feng Y, et al. Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats. Eur Respir J. 2009;33:1122-32 pubmed publisher |
| Oh S, Zheng T, Kim Y, Cohn L, Homer R, McKenzie A, et al. A critical role of SHP-1 in regulation of type 2 inflammation in the lung. Am J Respir Cell Mol Biol. 2009;40:568-74 pubmed publisher |
| Ishimoto H, Mukae H, Sakamoto N, Amenomori M, Kitazaki T, Imamura Y, et al. Different effects of telithromycin on MUC5AC production induced by human neutrophil peptide-1 or lipopolysaccharide in NCI-H292 cells compared with azithromycin and clarithromycin. J Antimicrob Chemother. 2009;63:109-14 pubmed publisher |
| Cho H, Imani F, Miller DeGraff L, Walters D, Melendi G, Yamamoto M, et al. Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. Am J Respir Crit Care Med. 2009;179:138-50 pubmed publisher |
- immunocytochemistry; rat; 1:500
| Almolki A, Guenegou A, Golda S, Boyer L, Benallaoua M, Amara N, et al. Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans. Am J Pathol. 2008;173:981-92 pubmed publisher |
| Ha U, Lim J, Kim H, Wu W, Jin S, Xu H, et al. MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem. 2008;283:30624-31 pubmed publisher |
- immunohistochemistry; mouse
| Kim J, Seandel M, Falciatori I, Wen D, Rafii S. CD34+ testicular stromal cells support long-term expansion of embryonic and adult stem and progenitor cells. Stem Cells. 2008;26:2516-22 pubmed publisher |
| Lee C, Hartl D, Matsuura H, Dunlop F, Scotney P, Fabri L, et al. Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production. Am J Respir Cell Mol Biol. 2008;39:739-46 pubmed publisher |
| Borchers M, Wesselkamper S, Eppert B, Motz G, Sartor M, Tomlinson C, et al. Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology. Toxicol Sci. 2008;105:188-99 pubmed publisher |
- immunohistochemistry; guinea pig; 1:50
| Cosen Binker L, Morris G, Vanner S, Gaisano H. Munc18/SNARE proteins' regulation of exocytosis in guinea pig duodenal Brunner's gland acini. World J Gastroenterol. 2008;14:2314-22 pubmed |
| Boldogh I, Aguilera Aguirre L, Bacsi A, Choudhury B, Saavedra Molina A, Kruzel M. Colostrinin decreases hypersensitivity and allergic responses to common allergens. Int Arch Allergy Immunol. 2008;146:298-306 pubmed publisher |
- immunocytochemistry; human; 1:500
| Malavia N, Mih J, Raub C, Dinh B, George S. IL-13 induces a bronchial epithelial phenotype that is profibrotic. Respir Res. 2008;9:27 pubmed publisher |
- immunocytochemistry; human; 1:100
| Takeyama K, Tamaoki J, Kondo M, Isono K, Nagai A. Role of epidermal growth factor receptor in maintaining airway goblet cell hyperplasia in rats sensitized to allergen. Clin Exp Allergy. 2008;38:857-65 pubmed publisher |
- immunohistochemistry; human
| Volin M, Shahrara S, Haines G, Woods J, Koch A. Expression of mucin 3 and mucin 5AC in arthritic synovial tissue. Arthritis Rheum. 2008;58:46-52 pubmed publisher |
| Lin K, Park J, Crews A, Li Y, Adler K. Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro. Int J Biochem Cell Biol. 2008;40:1379-88 pubmed |
- immunohistochemistry; human; 1:100
| Yan F, Li W, Jono H, Li Q, Zhang S, Li J, et al. Reactive oxygen species regulate Pseudomonas aeruginosa lipopolysaccharide-induced MUC5AC mucin expression via PKC-NADPH oxidase-ROS-TGF-alpha signaling pathways in human airway epithelial cells. Biochem Biophys Res Commun. 2008;366:513-9 pubmed |
| Shen H, Yoshida H, Yan F, Li W, Xu F, Huang H, et al. Synergistic induction of MUC5AC mucin by nontypeable Haemophilus influenzae and Streptococcus pneumoniae. Biochem Biophys Res Commun. 2008;365:795-800 pubmed |
| Deshmukh H, Shaver C, Case L, Dietsch M, Wesselkamper S, Hardie W, et al. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008;38:446-54 pubmed |
- immunohistochemistry; mouse; 1:100
| Yoshizawa N, Takenaka Y, Yamaguchi H, Tetsuya T, Tanaka H, Tatematsu M, et al. Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori. Lab Invest. 2007;87:1265-76 pubmed |
| Borchers M, Wesselkamper S, Harris N, Deshmukh H, Beckman E, Vitucci M, et al. CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure. Exp Mol Pathol. 2007;83:301-10 pubmed |
- immunohistochemistry; mouse
| Seandel M, James D, Shmelkov S, Falciatori I, Kim J, Chavala S, et al. Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature. 2007;449:346-50 pubmed |
- immunohistochemistry; mouse; 1:300
| Okazaki M, Gelman A, Tietjens J, Ibricevic A, Kornfeld C, Huang H, et al. Maintenance of airway epithelium in acutely rejected orthotopic vascularized mouse lung transplants. Am J Respir Cell Mol Biol. 2007;37:625-30 pubmed |
- immunohistochemistry; human; 1:100
| Wang Y, Gao J, Li Z, Jin Z, Gong Y, Man X. Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas. Int J Cancer. 2007;121:2716-22 pubmed |
| Kim S, Hong J, Ryu S, Chung W, Yoon J, Koo J. Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway. Mol Cell Biol. 2007;27:6933-47 pubmed |
- immunocytochemistry; human; 1:200
- ELISA; human; 1:100
| Kim Y, Won T, Kim S, Min Y, Lee C, Rhee C. Histamine induces MUC5AC expression via a hCLCA1 pathway. Pharmacology. 2007;80:219-26 pubmed |
- immunohistochemistry; mouse; 1:200
| Mohsenin A, Mi T, Xia Y, Kellems R, Chen J, Blackburn M. Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2007;293:L753-61 pubmed |
- immunoprecipitation; rat; 1:200
| Li R, Meng Z, Xie J. Effects of sulfur dioxide on the expressions of MUC5AC and ICAM-1 in airway of asthmatic rats. Regul Toxicol Pharmacol. 2007;48:284-91 pubmed |
- immunohistochemistry; mouse
| Xiang Y, Wang S, Liu M, Hirota J, Li J, Ju W, et al. A GABAergic system in airway epithelium is essential for mucus overproduction in asthma. Nat Med. 2007;13:862-7 pubmed |
- immunocytochemistry; human; 1:100
| Skowron zwarg M, Boland S, Caruso N, Coraux C, Marano F, Tournier F. Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation. Exp Cell Res. 2007;313:2695-702 pubmed |
- immunocytochemistry; human; 1:200
| Gomperts B, Kim L, Flaherty S, Hackett B. IL-13 regulates cilia loss and foxj1 expression in human airway epithelium. Am J Respir Cell Mol Biol. 2007;37:339-46 pubmed |
- immunohistochemistry; mouse
| Que J, Okubo T, Goldenring J, Nam K, Kurotani R, Morrisey E, et al. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development. 2007;134:2521-31 pubmed |
| Hosokawa T, Betsuyaku T, Nishimura M, Furuyama A, Katagiri K, Mochitate K. Differentiation of tracheal basal cells to ciliated cells and tissue reconstruction on the synthesized basement membrane substratum in vitro. Connect Tissue Res. 2007;48:9-18 pubmed |
| Hallstrand T, Debley J, Farin F, Henderson W. Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction. J Allergy Clin Immunol. 2007;119:1092-8 pubmed |
| Ha U, Lim J, Jono H, Koga T, Srivastava A, Malley R, et al. A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. J Immunol. 2007;178:1736-47 pubmed |
- immunocytochemistry; human; 2 ug/ml
| Maunders H, Patwardhan S, Phillips J, Clack A, Richter A. Human bronchial epithelial cell transcriptome: gene expression changes following acute exposure to whole cigarette smoke in vitro. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1248-56 pubmed |
| Wu Q, Martin R, Rino J, Jeyaseelan S, Breed R, Chu H. A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1064-72 pubmed |
- immunohistochemistry; human; 1:500
- ELISA; human; 1:500
| Finzi L, Barbu V, Burgel P, Mergey M, Kirkwood K, Wick E, et al. MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder. Am J Pathol. 2006;169:2031-41 pubmed |
- immunocytochemistry; human; 1:200
| Carolan B, Heguy A, Harvey B, Leopold P, Ferris B, Crystal R. Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers. Cancer Res. 2006;66:10729-40 pubmed |
- blocking or activating experiments; human
- immunocytochemistry; human
| Shinagawa K, Martin J, Ploplis V, Castellino F. Coagulation factor Xa modulates airway remodeling in a murine model of asthma. Am J Respir Crit Care Med. 2007;175:136-43 pubmed |
- immunohistochemistry; rat; 1:500
| Kobayashi K, Nomoto Y, Suzuki T, Tada Y, Miyake M, Hazama A, et al. Effect of fibroblasts on tracheal epithelial regeneration in vitro. Tissue Eng. 2006;12:2619-28 pubmed |
- immunohistochemistry; human; 1:500
| Burgel P, Montani D, Danel C, Dusser D, Nadel J. A morphometric study of mucins and small airway plugging in cystic fibrosis. Thorax. 2007;62:153-61 pubmed |
- immunohistochemistry; human; 1:1000
| Hays S, Fahy J. Characterizing mucous cell remodeling in cystic fibrosis: relationship to neutrophils. Am J Respir Crit Care Med. 2006;174:1018-24 pubmed |
- immunohistochemistry; mouse; 1:300
- immunohistochemistry; human; 1:300
- immunohistochemistry; dogs; 1:300
| Ibricevic A, Pekosz A, Walter M, Newby C, Battaile J, Brown E, et al. Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells. J Virol. 2006;80:7469-80 pubmed |
- immunohistochemistry; mouse
| Vaughan M, Ramirez R, Wright W, Minna J, Shay J. A three-dimensional model of differentiation of immortalized human bronchial epithelial cells. Differentiation. 2006;74:141-8 pubmed |
| Fulkerson P, Fischetti C, Hassman L, Nikolaidis N, Rothenberg M. Persistent effects induced by IL-13 in the lung. Am J Respir Cell Mol Biol. 2006;35:337-46 pubmed |
- immunohistochemistry; mouse; 2 ug/ml
| Patel A, Morton J, Kim E, Alevy Y, Swanson S, Tucker J, et al. Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members. Physiol Genomics. 2006;25:502-13 pubmed |
- immunohistochemistry; mouse; 2 ug/ml
| Deppong C, Juehne T, Hurchla M, Friend L, Shah D, Rose C, et al. Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation. J Immunol. 2006;176:3909-13 pubmed |
- immunohistochemistry; human; 1:100
| Wang R, Fang D. Effects of Helicobacter pylori infection on mucin expression in gastric carcinoma and pericancerous tissues. J Gastroenterol Hepatol. 2006;21:425-31 pubmed |
| Phillips J, Case N, Celly C, Chapman R, Hey J, Minnicozzi M. An enzyme-linked immunosorbent assay (ELISA) for the determination of mucin levels in bronchoalveolar lavage fluid. J Pharmacol Toxicol Methods. 2006;53:160-7 pubmed |
- immunohistochemistry; guinea pig; 1:100
- ELISA; guinea pig
- western blot; guinea pig
| Chorley B, Crews A, Li Y, Adler K, Minnicozzi M, Martin L. Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro. Respir Res. 2006;7:35 pubmed |
- immunohistochemistry; human
| Tyner J, Kim E, Ide K, Pelletier M, Roswit W, Morton J, et al. Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. J Clin Invest. 2006;116:309-21 pubmed |
| Lee S, Kang E, Hur G, Jung K, Jung H, Lee S, et al. Peroxisome proliferator-activated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol. 2006;291:L84-90 pubmed |
- western blot; mouse; 1:500
| Lee P, Zhang X, Shan P, Ma B, Lee C, Homer R, et al. ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest. 2006;116:163-73 pubmed |
| Chokki M, Eguchi H, Hamamura I, Mitsuhashi H, Kamimura T. Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells. FEBS J. 2005;272:6387-99 pubmed |
| Glader P, Moller S, Lilja J, Wieslander E, Löfdahl C, von Wachenfeldt K. Cigarette smoke extract modulates respiratory defence mechanisms through effects on T-cells and airway epithelial cells. Respir Med. 2006;100:818-27 pubmed |
- immunohistochemistry; human; 1:300
| Hoshino M, Fujita Y, Saji J, Inoue T, Nakagawa T, Miyazawa T. Effect of suplatast tosilate on goblet cell metaplasia in patients with asthma. Allergy. 2005;60:1394-400 pubmed |
- immunohistochemistry; mouse
| Grubb B, Rogers T, Diggs P, Boucher R, Ostrowski L. Culture of murine nasal epithelia: model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 2006;290:L270-7 pubmed |
| Park J, He F, Martin L, Li Y, Chorley B, Adler K. Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C{delta}-mediated mechanism. Am J Pathol. 2005;167:651-61 pubmed |
- immunocytochemistry; human; 1:500
| Kim S, Schein A, Nadel J. E-cadherin promotes EGFR-mediated cell differentiation and MUC5AC mucin expression in cultured human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2005;289:L1049-60 pubmed |
- western blot; human; 1:100
| Lee S, Kang E, Hur G, Jung K, Jung H, Lee S, et al. The inhibitory effects of rebamipide on cigarette smoke-induced airway mucin production. Respir Med. 2006;100:503-11 pubmed |
| Kitazaki T, Soda H, Doi S, Nakano H, Nakamura Y, Kohno S. Gefitinib inhibits MUC5AC synthesis in mucin-secreting non-small cell lung cancer cells. Lung Cancer. 2005;50:19-24 pubmed |
- immunohistochemistry; human
| Dong B, Xie Y, Chen K, Wang T, Tang W, You W, et al. Differences in biological features of gastric dysplasia, indefinite dysplasia, reactive hyperplasia and discriminant analysis of these lesions. World J Gastroenterol. 2005;11:3595-600 pubmed |
- immunohistochemistry; human
| Dennis J, Hvidsten T, Wit E, Komorowski J, Bell A, Downie I, et al. Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm. Clin Cancer Res. 2005;11:3766-72 pubmed |
- immunohistochemistry; human; 1:100
| Sun Y, Li J, He J, Zhou L, Chen K. Tissue microarray analysis of multiple gene expression in intestinal metaplasia, dysplasia and carcinoma of the stomach. Histopathology. 2005;46:505-14 pubmed |
- immunocytochemistry; human
| PEREZ VILAR J, Olsen J, Chua M, Boucher R. pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells. J Biol Chem. 2005;280:16868-81 pubmed |
- immunohistochemistry; human; 1:1000
| Kamio K, Matsushita I, Hijikata M, Kobashi Y, Tanaka G, Nakata K, et al. Promoter analysis and aberrant expression of the MUC5B gene in diffuse panbronchiolitis. Am J Respir Crit Care Med. 2005;171:949-57 pubmed |
- immunohistochemistry; human; 1:100
- ELISA; human; 1:100
- western blot; human; 1:500
| Mata M, Sarria B, Buenestado A, Cortijo J, Cerda M, Morcillo E. Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells. Thorax. 2005;60:144-52 pubmed |
- western blot; mouse; 1:250
| Beum P, Basma H, Bastola D, Cheng P. Mucin biosynthesis: upregulation of core 2 beta 1,6 N-acetylglucosaminyltransferase by retinoic acid and Th2 cytokines in a human airway epithelial cell line. Am J Physiol Lung Cell Mol Physiol. 2005;288:L116-24 pubmed |
| Lu W, Lillehoj E, Kim K. Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells. Am J Physiol Lung Cell Mol Physiol. 2005;288:L52-60 pubmed |
| Lieber C, Cox R, Sourimant J, Wolf J, Juergens K, Phung Q, et al. SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model. Nat Commun. 2022;13:4416 pubmed publisher |
| Sourimant J, Lieber C, Yoon J, Toots M, Govindarajan M, Udumula V, et al. Orally efficacious lead of the AVG inhibitor series targeting a dynamic interface in the respiratory syncytial virus polymerase. Sci Adv. 2022;8:eabo2236 pubmed publisher |
| Keeler S, Yantis J, Gerovac B, Youkilis S, Podgorny S, Mao D, et al. Chloride channel accessory 1 gene deficiency causes selective loss of mucus production in a new pig model. Am J Physiol Lung Cell Mol Physiol. 2022;322:L842-L852 pubmed publisher |
| Carraro G, Langerman J, Sabri S, Lorenzana Z, Purkayastha A, Zhang G, et al. Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition. Nat Med. 2021;27:806-814 pubmed publisher |
| Liu F, Fu J, Bergstrom K, Shan X, McDaniel J, McGee S, et al. Core 1-derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancer. J Exp Med. 2020;217: pubmed publisher |
| Kaur S, Smith L, Patel A, Menning M, Watley D, Malik S, et al. A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study. Am J Gastroenterol. 2017;112:172-183 pubmed publisher |
| Berube K, Aufderheide M, Breheny D, Clothier R, Combes R, Duffin R, et al. In vitro models of inhalation toxicity and disease. The report of a FRAME workshop. Altern Lab Anim. 2009;37:89-141 pubmed |
| Rowe R, Brody S, Pekosz A. Differentiated cultures of primary hamster tracheal airway epithelial cells. In Vitro Cell Dev Biol Anim. 2004;40:303-11 pubmed |
| Hewson C, Edbrooke M, Johnston S. PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms. J Mol Biol. 2004;344:683-95 pubmed |
| Chu H, Balzar S, Seedorf G, Westcott J, Trudeau J, Silkoff P, et al. Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma. Am J Pathol. 2004;165:1097-106 pubmed |
| Burgel P, Cardell L, Ueki I, Nadel J. Intranasal steroids decrease eosinophils but not mucin expression in nasal polyps. Eur Respir J. 2004;24:594-600 pubmed |
| Imamura Y, Yanagihara K, Mizuta Y, Seki M, Ohno H, Higashiyama Y, et al. Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-Oxododecanoyl) homoserine lactone in NCI-H292 Cells. Antimicrob Agents Chemother. 2004;48:3457-61 pubmed |
| Gray T, Nettesheim P, Loftin C, Koo J, Bonner J, Peddada S, et al. Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling. Mol Pharmacol. 2004;66:337-46 pubmed |
| Losi L, Scarselli A, Benatti P, Ponz de Leon M, Roncucci L, Pedroni M, et al. Relationship between MUC5AC and altered expression of MLH1 protein in mucinous and non-mucinous colorectal carcinomas. Pathol Res Pract. 2004;200:371-7 pubmed |
| Sueyoshi S, Miyata Y, Masumoto Y, Ishibashi Y, Matsuzawa S, Harano N, et al. Reduced airway inflammation and remodeling in parallel with mucin 5AC protein expression decreased by s-carboxymethylcysteine, a mucoregulant, in the airways of rats exposed to sulfur dioxide. Int Arch Allergy Immunol. 2004;134:273-80 pubmed |
| Pal Ghosh S, Pajoohesh Ganji A, Brown M, Stepp M. A mouse model for the study of recurrent corneal epithelial erosions: alpha9beta1 integrin implicated in progression of the disease. Invest Ophthalmol Vis Sci. 2004;45:1775-88 pubmed |
| Rossi G, Murer B, Cavazza A, Losi L, Natali P, Marchioni A, et al. Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression. Am J Surg Pathol. 2004;28:442-52 pubmed |
| Kikuchi T, Shively J, Foley J, Drazen J, Tschumperlin D. Differentiation-dependent responsiveness of bronchial epithelial cells to IL-4/13 stimulation. Am J Physiol Lung Cell Mol Physiol. 2004;287:L119-26 pubmed |
| Mitsuhashi A, Yamazawa K, Nagai Y, Tanaka N, Matsui H, Sekiya S. Correlation between MUC5AC expression and the prognosis of patients with adenocarcinoma of the uterine cervix. Ann Surg Oncol. 2004;11:40-4 pubmed |
| Mata M, Ruiz A, Cerda M, Martinez Losa M, Cortijo J, Santangelo F, et al. Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats. Eur Respir J. 2003;22:900-5 pubmed |
| Gray T, Coakley R, Hirsh A, Thornton D, Kirkham S, Koo J, et al. Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia. Am J Physiol Lung Cell Mol Physiol. 2004;286:L320-30 pubmed |
| Blackburn M, Lee C, Young H, Zhu Z, Chunn J, Kang M, et al. Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J Clin Invest. 2003;112:332-44 pubmed |
| Wang J, Chang C, Hsieh J, Lee L, Huang T, Chai C, et al. Role of MUC1 and MUC5AC expressions as prognostic indicators in gastric carcinomas. J Surg Oncol. 2003;83:253-60 pubmed |
| Atherton H, Jones G, Danahay H. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol Lung Cell Mol Physiol. 2003;285:L730-9 pubmed |
| Wagner J, Van Dyken S, Wierenga J, Hotchkiss J, Harkema J. Ozone exposure enhances endotoxin-induced mucous cell metaplasia in rat pulmonary airways. Toxicol Sci. 2003;74:437-46 pubmed |
| Wang R, Fang D. Alterations of MUC1 and MUC3 expression in gastric carcinoma: relevance to patient clinicopathological features. J Clin Pathol. 2003;56:378-84 pubmed |
| Kohri K, Ueki I, Nadel J. Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation. Am J Physiol Lung Cell Mol Physiol. 2002;283:L531-40 pubmed |
| Walter M, Morton J, Kajiwara N, Agapov E, Holtzman M. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. J Clin Invest. 2002;110:165-75 pubmed |
| Lee C, Homer R, Cohn L, Link H, Jung S, Craft J, et al. Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. J Biol Chem. 2002;277:35466-74 pubmed |
| Koo J, Kim Y, Jetten A, Belloni P, Nettesheim P. Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist. Exp Lung Res. 2002;28:315-32 pubmed |
| Hoshino M, Morita S, Iwashita H, Sagiya Y, Nagi T, Nakanishi A, et al. Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway. Am J Respir Crit Care Med. 2002;165:1132-6 pubmed |
| Toshida H, Nakata K, Hamano T, Nakamura M, Nguyen D, Beuerman R. Effect of gefarnate on the ocular surface in squirrel monkeys. Cornea. 2002;21:292-9 pubmed |
| Burgel P, Lazarus S, Tam D, Ueki I, Atabai K, Birch M, et al. Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation. J Immunol. 2001;167:5948-54 pubmed |
| Wilson H, Chauhan J, Kerry P, Evans J. Ethanol vapour-fixation of rat lung for immunocytochemistry investigations. J Immunol Methods. 2001;247:187-90 pubmed |
| Takeyama K, Dabbagh K, Jeong Shim J, Dao Pick T, Ueki I, Nadel J. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol. 2000;164:1546-52 pubmed |
| Stanley C, Phillips T. Selective secretion and replenishment of discrete mucin glycoforms from intestinal goblet cells. Am J Physiol. 1999;277:G191-200 pubmed publisher |
