POLB Monoclonal Antibody (61) | Invitrogen MA5-12086 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

POLB Monoclonal Antibody (61)

catalog :

MA5-12086

quantity :

500 µL

price :

US 496.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot

citations: 6

Reference
Sykora P, Witt K, Revanna P, Smith Roe S, Dismukes J, Lloyd D, et al. Next generation high throughput DNA damage detection platform for genotoxic compound screening. Sci Rep. 2018;8:2771 pubmed publisher
Fang Q, Inanç B, Schamus S, Wang X, Wei L, Brown A, et al. HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase Î². Nat Commun. 2014;5:5513 pubmed publisher
Li J, Luthra S, Wang X, Chandran U, Sobol R. Transcriptional profiling reveals elevated Sox2 in DNA polymerase ß null mouse embryonic fibroblasts. Am J Cancer Res. 2012;2:699-713 pubmed
Yoder K, Espeseth A, Wang X, Fang Q, Russo M, Lloyd R, et al. The base excision repair pathway is required for efficient lentivirus integration. PLoS ONE. 2011;6:e17862 pubmed publisher
Tang J, Svilar D, Trivedi R, Wang X, Goellner E, Moore B, et al. N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide. Neuro Oncol. 2011;13:471-86 pubmed publisher
Jelezcova E, Trivedi R, Wang X, Tang J, Brown A, Goellner E, et al. Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage. Mutat Res. 2010;686:57-67 pubmed publisher

product information

Product Type :

Antibody

Product Name :

POLB Monoclonal Antibody (61)

Catalog # :

MA5-12086

Quantity :

500 µL

Price :

US 496.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 2-4 µg/mL

Species :

Human, Mouse, Rat

Clone :

Isotype :

IgG2a

Storage :

4° C

Description :

DNA polymerase beta comprises an amino-terminal 8- kDa domain and a carboxy-terminal 31- kDa domain. The N-terminal ssDNA binding domain has a deoxyribose phosphodiesterase activity while the C-terminal domain has a nucleotidyltransferase activity. Mammalian DNA polymerase beta, a DNA repair polymerase, is constitutively expressed in cultured cells, but treatment of cells with the DNA-alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate up-regulates beta-pol level. DNA polymerase beta fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells.

Immunogen :

DNA polymerase beta protein

Format :

Liquid

Applications w/Dilutions :

Western Blot: 2-4 µg/mL

Aliases :

A430088C08Rik; DNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; DNA-directed DNA polymerase beta; hypothetical protein LOC614688; LOW QUALITY PROTEIN: DNA polymerase beta; MGC125976; POL B; Pol beta; POLB; polb.S; polymerase (DNA directed), beta; polymerase (DNA directed), beta S homeolog; polymerase (DNA) beta; polymerase B; polymerase-beta; wu:fa97a05; XELAEV_18020165mg; zgc:109924