c-Myc Monoclonal Antibody (9E10.3) | Invitrogen MA5-12080 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

c-Myc Monoclonal Antibody (9E10.3)

catalog :

MA5-12080

quantity :

500 uL

price :

US 423.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9E10.3

The same clone is also sold as:

Novus Biologicals: NBP2-45144-0.1mg, NBP2-47738-0.1mg

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

citations: 55

Reference
Wang R, Peng C, Song J, Hua Y, Wu Q, Deng L, et al. Downregulated RRS1 inhibits invasion and metastasis of BT549 through RPL11‑c‑Myc‑SNAIL axis. Int J Oncol. 2022;60: pubmed publisher
Macia M, Halbritter J, Delous M, Bredrup C, Gutter A, Filhol E, et al. Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis. Am J Hum Genet. 2017;100:323-333 pubmed publisher
Leal M, Ribeiro H, Rey J, Pinto G, Smith M, Moreira Nunes C, et al. YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells: new insights about YWHAE role in the tumor development and metastasis process. Oncotarget. 2016;7:85393-85410 pubmed publisher
Derussy B, Boland M, Tandon R. Human Cytomegalovirus pUL93 Links Nucleocapsid Maturation and Nuclear Egress. J Virol. 2016;90:7109-7117 pubmed publisher
Ramena G, Yin Y, Yu Y, Walia V, Elble R. CLCA2 Interactor EVA1 Is Required for Mammary Epithelial Cell Differentiation. PLoS ONE. 2016;11:e0147489 pubmed publisher
Akay O, Aras B, Isiksoy S, Toprak C, Mutlu F, Artan S, et al. BCL2, BCL6, IGH, TP53, and MYC protein expression and gene rearrangements as prognostic markers in diffuse large B-cell lymphoma: a study of 44 Turkish patients. Cancer Genet. 2014;207:87-93 pubmed publisher
Jacobs M, Persons D, Fraga G. EGFR and MYC gene copy number aberrations are more common in squamous cell carcinoma than keratoacanthoma: a FISH study. J Cutan Pathol. 2013;40:447-54 pubmed publisher
Cattoretti G. MYC expression and distribution in normal mature lymphoid cells. J Pathol. 2013;229:430-40 pubmed publisher
Unger C, Popescu R, Giessrigl B, Laimer D, Heider S, Seelinger M, et al. The dichloromethane extract of the ethnomedicinal plant Neurolaena lobata inhibits NPM/ALK expression which is causal for anaplastic large cell lymphomagenesis. Int J Oncol. 2013;42:338-48 pubmed publisher
Novellino L, Rossi R, Bonino F, Cavallone D, Abrignani S, Pagani M, et al. Circulating hepatitis B surface antigen particles carry hepatocellular microRNAs. PLoS ONE. 2012;7:e31952 pubmed publisher
Giaginis C, Politi E, Alexandrou P, Sfiniadakis J, Kouraklis G, Theocharis S. Expression of peroxisome proliferator activated receptor-gamma (PPAR-?) in human non-small cell lung carcinoma: correlation with clinicopathological parameters, proliferation and apoptosis related molecules and patients' survival. Pathol Oncol Res. 2012;18:875-83 pubmed
Huang Y, Chiang N, Hu C, Hsiao C, Cheng K, Tsai W, et al. Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains. Mol Cell Biol. 2012;32:1408-20 pubmed publisher
Lanham K, Prasch A, Weina K, Peterson R, Heideman W. A dominant negative zebrafish Ahr2 partially protects developing zebrafish from dioxin toxicity. PLoS ONE. 2011;6:e28020 pubmed publisher
Challagundla K, Sun X, Zhang X, Devine T, Zhang Q, Sears R, et al. Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. Mol Cell Biol. 2011;31:4007-21 pubmed publisher
Genovese N, Broker T, Chow L. Nonconserved lysine residues attenuate the biological function of the low-risk human papillomavirus E7 protein. J Virol. 2011;85:5546-54 pubmed publisher
Li N, Wang J, Shen S, Bu X, Tian X, Huang P. Expression of p53, Ki-67 and c-Myc proteins is predictive of the surgical molecular margin in colorectal carcinoma. Pathol Oncol Res. 2011;17:479-87 pubmed publisher
Faucherre A, Lopez Schier H. Delaying Gal4-driven gene expression in the zebrafish with morpholinos and Gal80. PLoS ONE. 2011;6:e16587 pubmed publisher
Huber P, Zhao W. Detection of protein-RNA complexes in Xenopus oocytes. Methods. 2010;51:82-6 pubmed publisher
Vo N, Madlener S, Bago Horvath Z, Herbacek I, Stark N, Gridling M, et al. Pro- and anticarcinogenic mechanisms of piceatannol are activated dose dependently in MCF-7 breast cancer cells. Carcinogenesis. 2010;31:2074-81 pubmed publisher
Calcagno D, Guimarães A, Leal M, Seabra A, Khayat A, Pontes T, et al. MYC insertions in diffuse-type gastric adenocarcinoma. Anticancer Res. 2009;29:2479-83 pubmed
Yang L, Shen L, Shao Y, Zhao Q, Zhang W. Cytoplasmic domain of human Fcalpha/mu receptor is required for ligand internalization. Cell Immunol. 2009;258:78-82 pubmed publisher
Katzenellenbogen R, Vliet Gregg P, Xu M, Galloway D. NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes. J Virol. 2009;83:6446-56 pubmed publisher
Altintas S, Lambein K, Huizing M, Braems G, Asjoe F, Hellemans H, et al. Prognostic significance of oncogenic markers in ductal carcinoma in situ of the breast: a clinicopathologic study. Breast J. 2009;15:120-32 pubmed publisher
Pridgeon J, Webber E, Sha D, Li L, Chin L. Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes. FEBS J. 2009;276:118-31 pubmed publisher
Kong D, Song S, Kim D, Joo K, Yoo J, Koh J, et al. Prognostic significance of c-Met expression in glioblastomas. Cancer. 2009;115:140-8 pubmed publisher
de Haas T, Hasselt N, Troost D, Caron H, Popovic M, Zadravec Zaletel L, et al. Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression. Clin Cancer Res. 2008;14:4154-60 pubmed publisher
Itahana K, Zhang Y. Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell. 2008;13:542-53 pubmed publisher
Fan Y, Wong L, Ding J, Spiridonov N, Johnson R, Johnson G. Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism. J Biol Chem. 2008;283:1588-96 pubmed
Olzmann J, Li L, Chudaev M, Chen J, Perez F, Palmiter R, et al. Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol. 2007;178:1025-38 pubmed
Miettinen P, Ustinov J, Ormio P, Gao R, Palgi J, Hakonen E, et al. Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth. Diabetes. 2006;55:3299-308 pubmed
Fokkema E, Timens W, de Vries E, de Jong S, Fidler V, Meijer C, et al. Expression and prognostic implications of apoptosis-related proteins in locally unresectable non-small cell lung cancers. Lung Cancer. 2006;52:241-7 pubmed
Kilianova Z, Basora N, Kilian P, Payet M, Gallo Payet N. Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. Endocrinology. 2006;147:2325-37 pubmed
Mason D, Keppler D, Zhang J, Jackson T, Seger Y, Matsui S, et al. Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts. Carcinogenesis. 2006;27:350-9 pubmed
Väisänen M, Väisänen T, Tu H, Pirilä P, Sormunen R, Pihlajaniemi T. The shed ectodomain of type XIII collagen associates with the fibrillar fibronectin matrix and may interfere with its assembly in vitro. Biochem J. 2006;393:43-50 pubmed
O Donnell K, Wentzel E, Zeller K, Dang C, Mendell J. c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 2005;435:839-43 pubmed
Talukder A, Gururaj A, Mishra S, Vadlamudi R, Kumar R. Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator. Mol Cell Biol. 2004;24:6581-91 pubmed
Bennasroune A, Fickova M, Gardin A, Dirrig Grosch S, Aunis D, Cremel G, et al. Transmembrane peptides as inhibitors of ErbB receptor signaling. Mol Biol Cell. 2004;15:3464-74 pubmed
Wei J, Sherman F. Sue1p is required for degradation of labile forms of altered cytochromes C in yeast mitochondria. J Biol Chem. 2004;279:30449-58 pubmed
Bruno M, West R, Schneeman T, Bresnick E, Kaetzel C. Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene. Mol Immunol. 2004;40:695-708 pubmed
Davis M, Ireton R, Reynolds A. A core function for p120-catenin in cadherin turnover. J Cell Biol. 2003;163:525-34 pubmed
Kefas B, Cai Y, Ling Z, Heimberg H, Hue L, Pipeleers D, et al. AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J Mol Endocrinol. 2003;30:151-61 pubmed
Baker Lepain J, Sarzotti M, Fields T, Li C, Nicchitta C. GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. J Exp Med. 2002;196:1447-59 pubmed
Hitzl M, Striessnig J, Neuhuber B, Flucher B. A mutation in the beta interaction domain of the Ca(2+) channel alpha(1C) subunit reduces the affinity of the (+)-[(3)H]isradipine binding site. FEBS Lett. 2002;524:188-92 pubmed
Chin L, Vavalle J, Li L. Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation. J Biol Chem. 2002;277:35071-9 pubmed
Piechocki M, Pilon S, Wei W. Quantitative measurement of anti-ErbB-2 antibody by flow cytometry and ELISA. J Immunol Methods. 2002;259:33-42 pubmed
Thiebot H, Louache F, Vaslin B, de Revel T, Neildez O, Larghero J, et al. Early and persistent bone marrow hematopoiesis defect in simian/human immunodeficiency virus-infected macaques despite efficient reduction of viremia by highly active antiretroviral therapy during primary infection. J Virol. 2001;75:11594-602 pubmed
Castoria G, Migliaccio A, Bilancio A, Di Domenico M, de Falco A, Lombardi M, et al. PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO J. 2001;20:6050-9 pubmed
Fukumoto T, Watanabe Fukunaga R, Fujisawa K, Nagata S, Fukunaga R. The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells. J Biol Chem. 2001;276:38441-8 pubmed
Suzuki M, Shinkai M, Honda H, Kamihira M, Iijima S, Kobayashi T. Construction of tumor-specific cells expressing a membrane-anchored single-chain Fv of anti-ErbB-2 antibody. Biochim Biophys Acta. 2001;1525:191-6 pubmed
Chavand O, Spilsbury K, Rakoczy P. Addition of a c-myc epitope tag within the VEGF protein does not affect in vitro biological activity. Biochem Cell Biol. 2001;79:107-12 pubmed
Bourgarel Rey V, El Khyari S, Rimet O, Bordas B, Guigal N, Braguer D, et al. Opposite effects of antimicrotubule agents on c-myc oncogene expression depending on the cell lines used. Eur J Cancer. 2000;36:1043-9 pubmed
de Caestecker M, Yahata T, Wang D, Parks W, Huang S, Hill C, et al. The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain. J Biol Chem. 2000;275:2115-22 pubmed
Zhang Y, Xiong Y. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol Cell. 1999;3:579-91 pubmed
Cooper J, Schilling G, Peters M, Herring W, Sharp A, Kaminsky Z, et al. Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Hum Mol Genet. 1998;7:783-90 pubmed
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product information

Product Type :

Antibody

Product Name :

c-Myc Monoclonal Antibody (9E10.3)

Catalog # :

MA5-12080

Quantity :

500 uL

Price :

US 423.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:25-1:50, Immunomicroscopy: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:50-1:200

Species :

Human

Clone :

9E10.3

Isotype :

IgG1, kappa

Storage :

4 C

Description :

The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.

Immunogen :

A synthetic peptide, aa 408-439, (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-myc

Format :

Liquid

Applications w/Dilutions :

Aliases :

AU016757; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; mMyc; MRTL; Myc; Myc protein; Myc proto-oncogene protein; MYC proto-oncogene, bHLH transcription factor; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; Niard; Nird; Proto-oncogene c-Myc; RNCMYC; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein