This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
c-Myc Monoclonal Antibody (9E10.3), Biotin
catalog :
MA5-12077
quantity :
500 uL
price :
US 469.00
clonality :
monoclonal
host :
mouse
conjugate :
biotin
clone name :
9E10.3

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 26
Reference
Akay O, Aras B, Isiksoy S, Toprak C, Mutlu F, Artan S, et al. BCL2, BCL6, IGH, TP53, and MYC protein expression and gene rearrangements as prognostic markers in diffuse large B-cell lymphoma: a study of 44 Turkish patients. Cancer Genet. 2014;207:87-93 pubmed publisher
Jacobs M, Persons D, Fraga G. EGFR and MYC gene copy number aberrations are more common in squamous cell carcinoma than keratoacanthoma: a FISH study. J Cutan Pathol. 2013;40:447-54 pubmed publisher
Cattoretti G. MYC expression and distribution in normal mature lymphoid cells. J Pathol. 2013;229:430-40 pubmed publisher
Unger C, Popescu R, Giessrigl B, Laimer D, Heider S, Seelinger M, et al. The dichloromethane extract of the ethnomedicinal plant Neurolaena lobata inhibits NPM/ALK expression which is causal for anaplastic large cell lymphomagenesis. Int J Oncol. 2013;42:338-48 pubmed publisher
Genovese N, Broker T, Chow L. Nonconserved lysine residues attenuate the biological function of the low-risk human papillomavirus E7 protein. J Virol. 2011;85:5546-54 pubmed publisher
Li N, Wang J, Shen S, Bu X, Tian X, Huang P. Expression of p53, Ki-67 and c-Myc proteins is predictive of the surgical molecular margin in colorectal carcinoma. Pathol Oncol Res. 2011;17:479-87 pubmed publisher
Faucherre A, Lopez Schier H. Delaying Gal4-driven gene expression in the zebrafish with morpholinos and Gal80. PLoS ONE. 2011;6:e16587 pubmed publisher
Huber P, Zhao W. Detection of protein-RNA complexes in Xenopus oocytes. Methods. 2010;51:82-6 pubmed publisher
Vo N, Madlener S, Bago Horvath Z, Herbacek I, Stark N, Gridling M, et al. Pro- and anticarcinogenic mechanisms of piceatannol are activated dose dependently in MCF-7 breast cancer cells. Carcinogenesis. 2010;31:2074-81 pubmed publisher
Calcagno D, Guimarães A, Leal M, Seabra A, Khayat A, Pontes T, et al. MYC insertions in diffuse-type gastric adenocarcinoma. Anticancer Res. 2009;29:2479-83 pubmed
Altintas S, Lambein K, Huizing M, Braems G, Asjoe F, Hellemans H, et al. Prognostic significance of oncogenic markers in ductal carcinoma in situ of the breast: a clinicopathologic study. Breast J. 2009;15:120-32 pubmed publisher
Pridgeon J, Webber E, Sha D, Li L, Chin L. Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes. FEBS J. 2009;276:118-31 pubmed publisher
de Haas T, Hasselt N, Troost D, Caron H, Popovic M, Zadravec Zaletel L, et al. Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression. Clin Cancer Res. 2008;14:4154-60 pubmed publisher
Itahana K, Zhang Y. Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell. 2008;13:542-53 pubmed publisher
Fan Y, Wong L, Ding J, Spiridonov N, Johnson R, Johnson G. Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism. J Biol Chem. 2008;283:1588-96 pubmed
Miettinen P, Ustinov J, Ormio P, Gao R, Palgi J, Hakonen E, et al. Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth. Diabetes. 2006;55:3299-308 pubmed
Fokkema E, Timens W, de Vries E, de Jong S, Fidler V, Meijer C, et al. Expression and prognostic implications of apoptosis-related proteins in locally unresectable non-small cell lung cancers. Lung Cancer. 2006;52:241-7 pubmed
Mason D, Keppler D, Zhang J, Jackson T, Seger Y, Matsui S, et al. Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts. Carcinogenesis. 2006;27:350-9 pubmed
Väisänen M, Väisänen T, Tu H, Pirilä P, Sormunen R, Pihlajaniemi T. The shed ectodomain of type XIII collagen associates with the fibrillar fibronectin matrix and may interfere with its assembly in vitro. Biochem J. 2006;393:43-50 pubmed
Talukder A, Gururaj A, Mishra S, Vadlamudi R, Kumar R. Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator. Mol Cell Biol. 2004;24:6581-91 pubmed
Bennasroune A, Fickova M, Gardin A, Dirrig Grosch S, Aunis D, Cremel G, et al. Transmembrane peptides as inhibitors of ErbB receptor signaling. Mol Biol Cell. 2004;15:3464-74 pubmed
Wei J, Sherman F. Sue1p is required for degradation of labile forms of altered cytochromes C in yeast mitochondria. J Biol Chem. 2004;279:30449-58 pubmed
Bruno M, West R, Schneeman T, Bresnick E, Kaetzel C. Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene. Mol Immunol. 2004;40:695-708 pubmed
Suzuki M, Shinkai M, Honda H, Kamihira M, Iijima S, Kobayashi T. Construction of tumor-specific cells expressing a membrane-anchored single-chain Fv of anti-ErbB-2 antibody. Biochim Biophys Acta. 2001;1525:191-6 pubmed
Zhang Y, Xiong Y. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol Cell. 1999;3:579-91 pubmed
Zhang Y, Xiong Y, Yarbrough W. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell. 1998;92:725-34 pubmed
product information
Product Type :
Antibody
Product Name :
c-Myc Monoclonal Antibody (9E10.3), Biotin
Catalog # :
MA5-12077
Quantity :
500 uL
Price :
US 469.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human
Applications :
Immunohistochemistry (Paraffin): 1:25-1:50, Western Blot: 1:50
Species :
Human
Clone :
9E10.3
Isotype :
IgG1, kappa
Storage :
4 C
Description :
The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.
Immunogen :
A synthetic peptide, aa 408-439, (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-myc
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 1:25-1:50, Western Blot: 1:50
Aliases :
AU016757; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; mMyc; MRTL; Myc; Myc protein; Myc proto-oncogene protein; MYC proto-oncogene, bHLH transcription factor; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; Niard; Nird; Proto-oncogene c-Myc; RNCMYC; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA