XPF Monoclonal Antibody (51) | Invitrogen MA5-12060 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

XPF Monoclonal Antibody (51)

catalog :

MA5-12060

quantity :

500 uL

price :

US 470.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human

application :

western blot

citations: 11

Reference
Guh C, Shen H, Chen L, Chiu P, Liao I, Lo C, et al. XPF activates break-induced telomere synthesis. Nat Commun. 2022;13:5781 pubmed publisher
Guffanti F, Alvisi M, Caiola E, Ricci F, De Maglie M, Soldati S, et al. Impact of ERCC1, XPF and DNA Polymerase β Expression on Platinum Response in Patient-Derived Ovarian Cancer Xenografts. Cancers (Basel). 2020;12: pubmed publisher
Chalasani S, Kawale A, Akopiants K, Yu Y, Fanta M, Weinfeld M, et al. Persistent 3'-phosphate termini and increased cytotoxicity of radiomimetic DNA double-strand breaks in cells lacking polynucleotide kinase/phosphatase despite presence of an alternative 3'-phosphatase. DNA Repair (Amst). 2018;68:12-24 pubmed publisher
Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis N, et al. Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biol. 2018;19:37 pubmed publisher
Alekseev S, Ayadi M, Brino L, Egly J, Larsen A, Coin F. A small molecule screen identifies an inhibitor of DNA repair inducing the degradation of TFIIH and the chemosensitization of tumor cells to platinum. Chem Biol. 2014;21:398-407 pubmed publisher
Tan L, Saijo M, Kuraoka I, Narita T, Takahata C, Iwai S, et al. Xeroderma pigmentosum group F protein binds to Eg5 and is required for proper mitosis: implications for XP-F and XFE. Genes Cells. 2012;17:173-85 pubmed publisher
Tomicic M, Reischmann P, Rasenberger B, Meise R, Kaina B, Christmann M. Delayed c-Fos activation in human cells triggers XPF induction and an adaptive response to UVC-induced DNA damage and cytotoxicity. Cell Mol Life Sci. 2011;68:1785-98 pubmed publisher
Muniandy P, Thapa D, Thazhathveetil A, Liu S, Seidman M. Repair of laser-localized DNA interstrand cross-links in G1 phase mammalian cells. J Biol Chem. 2009;284:27908-17 pubmed publisher
Mocquet V, Laine J, Riedl T, Yajin Z, Lee M, Egly J. Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step. EMBO J. 2008;27:155-67 pubmed
Mogi S, Oh D. gamma-H2AX formation in response to interstrand crosslinks requires XPF in human cells. DNA Repair (Amst). 2006;5:731-40 pubmed
Coin F, Auriol J, Tapias A, Clivio P, Vermeulen W, Egly J. Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity. EMBO J. 2004;23:4835-46 pubmed

product information

Product Type :

Antibody

Product Name :

XPF Monoclonal Antibody (51)

Catalog # :

MA5-12060

Quantity :

500 uL

Price :

US 470.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ChIP Assay: 1.5 ug/10^6 cells, Western Blot: 1-3 ug/mL

Species :

Human

Clone :

Isotype :

IgG2b, kappa

Storage :

4 C

Description :

The structure specific ERCC 1 / XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells, XPG cleaves 3' of the DNA lesion while the ERCC1 / XPF complex makes the 5' incision. ERCC1 / XPF probably plays a role in processing partially processed recombination intermediates.

Immunogen :

Recombinant human XPF protein

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 1.5 ug/10^6 cells, Western Blot: 1-3 ug/mL

Aliases :

AI606920; DNA excision repair protein ERCC-4; DNA repair endonuclease subunit; DNA repair endonuclease XPF; DNA repair protein complementing XP-F cells; ERCC excision repair 4, endonuclease catalytic subunit; ERCC11; ERCC4; Ercc4 protein-like; excision repair cross-complementation group 4; excision repair cross-complementing rodent repair deficiency, complementation group 4; excision-repair, complementing defective, in Chinese hamster; FANCQ; RAD1; RGD1560340; Xeroderma pigmentosum group F-complementing protein; xeroderma pigmentosum, complementation group F; XFEPS; XPF