This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Fibronectin Monoclonal Antibody (FBN11)
catalog :
MA5-11981
quantity :
500 µL
price :
US 440.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
FBN11
reactivity :
human, mouse, rat, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 42
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 5d
Xu J, Zhu S, Heng B, Dissanayaka W, Zhang C. TGF-?1-induced differentiation of SHED into functional smooth muscle cells. Stem Cell Res Ther. 2017;8:10 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1f
Gong T, Heng B, Xu J, Zhu S, Yuan C, Lo E, et al. Decellularized extracellular matrix of human umbilical vein endothelial cells promotes endothelial differentiation of stem cells from exfoliated deciduous teeth. J Biomed Mater Res A. 2017;105:1083-1093 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Choi S, Piao Z, Jin L, Kim J, Kim G, Ryu Y, et al. Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling. PLoS ONE. 2016;11:e0167340 pubmed publisher
  • western blot; human; loading ...; fig 1a
Choi S, Kee H, Kurz T, Hansen F, Ryu Y, Kim G, et al. Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells. J Cell Mol Med. 2016;20:2289-2298 pubmed publisher
  • immunocytochemistry; human; fig 1
Heng B, Zhu S, Xu J, Yuan C, Gong T, Zhang C. Effects of decellularized matrices derived from periodontal ligament stem cells and SHED on the adhesion, proliferation and osteogenic differentiation of human dental pulp stem cells in vitro. Tissue Cell. 2016;48:133-43 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:500
Kokubo M, Sato M, Yamato M, Mitani G, Kutsuna T, Ebihara G, et al. Characterization of chondrocyte sheets prepared using a co-culture method with temperature-responsive culture inserts. J Tissue Eng Regen Med. 2016;10:486-95 pubmed publisher
  • immunohistochemistry; rhesus macaque
Klatt N, Canary L, Sun X, Vinton C, Funderburg N, Morcock D, et al. Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. J Clin Invest. 2013;123:903-7 pubmed publisher
  • immunohistochemistry; mouse
Bravo Nuevo A, O Donnell R, Rosendahl A, Chung J, Benjamin L, Odaka C. RhoB deficiency in thymic medullary epithelium leads to early thymic atrophy. Int Immunol. 2011;23:593-600 pubmed publisher
  • immunocytochemistry; human; 1:200
Liu K, Li Y, Wang H, Jiang X, Zhao Y, Sun D, et al. The immunohistochemical characterization of human fetal olfactory bulb and olfactory ensheathing cells in culture as a source for clinical CNS restoration. Anat Rec (Hoboken). 2010;293:359-69 pubmed publisher
  • immunohistochemistry; human
Rnjak J, Li Z, Maitz P, Wise S, Weiss A. Primary human dermal fibroblast interactions with open weave three-dimensional scaffolds prepared from synthetic human elastin. Biomaterials. 2009;30:6469-77 pubmed publisher
  • immunohistochemistry; human; 1:500
Mitani G, Sato M, Lee J, Kaneshiro N, Ishihara M, Ota N, et al. The properties of bioengineered chondrocyte sheets for cartilage regeneration. BMC Biotechnol. 2009;9:17 pubmed publisher
  • immunohistochemistry; rat; 1:100
Liao P, Li G, Yu D, Yong T, Wang J, Wang J, et al. Molecular alteration of Ca(v)1.2 calcium channel in chronic myocardial infarction. Pflugers Arch. 2009;458:701-11 pubmed publisher
  • immunohistochemistry; human
Andersen T, Sondergaard T, Skorzynska K, Dagnaes Hansen F, Plesner T, Hauge E, et al. A physical mechanism for coupling bone resorption and formation in adult human bone. Am J Pathol. 2009;174:239-47 pubmed publisher
  • immunocytochemistry; rhesus macaque; 20 ug/ml
Cao W, Mah K, Carroll R, Slayden O, Brenner R. Progesterone withdrawal up-regulates fibronectin and integrins during menstruation and repair in the rhesus macaque endometrium. Hum Reprod. 2007;22:3223-31 pubmed publisher
  • immunohistochemistry; rat; 1:100
Guo Z, Yan Z, Bai L, Zhang M, Jiang Z. Flow shear stress affects macromolecular accumulation through modulation of internal elastic lamina fenestrae. Clin Biomech (Bristol, Avon). 2008;23 Suppl 1:S104-11 pubmed
  • immunohistochemistry; rat; 1:100
Shynlova O, Williams S, Draper H, White B, MacPhee D, Lye S. Uterine stretch regulates temporal and spatial expression of fibronectin protein and its alpha 5 integrin receptor in myometrium of unilaterally pregnant rats. Biol Reprod. 2007;77:880-8 pubmed
  • immunohistochemistry; rat; 1:100
  • western blot; rat; 1:100
Cui C, Chen A, Jiang Z, Wu Q, Lin J, Wen H, et al. Inhibition of NAD(P)H oxidase reduces fibronectin expression in stroke-prone renovascular hypertensive rat brain. Clin Exp Pharmacol Physiol. 2007;34:304-9 pubmed
  • immunohistochemistry; rat
Guven A, Yavuz O, Cam M, Ercan F, Bukan N, Comunoglu C. Melatonin protects against epirubicin-induced cardiotoxicity. Acta Histochem. 2007;109:52-60 pubmed
Hanetseder D, Levstek T, Teuschl Woller A, Frank J, Schaedl B, Redl H, et al. Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age. Front Bioeng Biotechnol. 2023;11:1214019 pubmed publisher
Danilov C, Thein T, Tahara S, Sch xf6 nthal A, Chen T. Intranasal Delivery of miR133b in a NEO100-Based Formulation Induces a Healing Response in Spinal Cord-Injured Mice. Cells. 2023;12: pubmed publisher
Wang Y, Jin J, Wang H, Ju L. Acoustic Force-Based Cell-Matrix Avidity Measurement in High Throughput. Biosensors (Basel). 2023;13: pubmed publisher
Liu Q, Liu Z, Gu H, Ge Y, Wu X, Zuo F, et al. Comparative study of differentiating human pluripotent stem cells into vascular smooth muscle cells in hydrogel-based culture methods. Regen Ther. 2023;22:39-49 pubmed publisher
Hamahashi K, Toyoda E, Ishihara M, Mitani G, Takagaki T, Kaneshiro N, et al. Polydactyly-derived allogeneic chondrocyte cell-sheet transplantation with high tibial osteotomy as regenerative therapy for knee osteoarthritis. NPJ Regen Med. 2022;7:71 pubmed publisher
Fang L, Wang X, Zhang M, Khan P, Tamm M, Roth M. MicroRNA-101-3p Suppresses mTOR and Causes Mitochondrial Fragmentation and Cell Degeneration in COPD. Can Respir J. 2022;2022:5933324 pubmed publisher
Smeda M, Jasztal A, Maleki E, Bar A, Sternak M, Kwiatkowski G, et al. Endothelial-mesenchymal transition induced by metastatic 4T1 breast cancer cells in pulmonary endothelium in aged mice. Front Mol Biosci. 2022;9:1050112 pubmed publisher
Fang L, Zhang M, Li J, Zhou L, Tamm M, Roth M. Airway Smooth Muscle Cell Mitochondria Damage and Mitophagy in COPD via ERK1/2 MAPK. Int J Mol Sci. 2022;23: pubmed publisher
Zhao T, Kee H, Kee S, Jeong M. Hdac8 Inhibitor Alleviates Transverse Aortic Constriction-Induced Heart Failure in Mice by Downregulating Ace1. Oxid Med Cell Longev. 2022;2022:6227330 pubmed publisher
Niemann S, Nguyen M, Eble J, Chasan A, Mrakovcic M, B xf6 ttcher R, et al. More Is Not Always Better-the Double-Headed Role of Fibronectin in Staphylococcus aureus Host Cell Invasion. MBio. 2021;12:e0106221 pubmed publisher
Dittloff K, Iezzi A, Zhong J, Mohindra P, Desai T, Russell B. Transthyretin amyloid fibrils alter primary fibroblast structure, function, and inflammatory gene expression. Am J Physiol Heart Circ Physiol. 2021;321:H149-H160 pubmed publisher
Ji S, Gumina D, McPeak K, Moldovan R, Post M, Su E. Human placental villous stromal extracellular matrix regulates fetoplacental angiogenesis in severe fetal growth restriction. Clin Sci (Lond). 2021;135:1127-1143 pubmed publisher
Zhou H, Li L, Xie W, Wu L, Lin Y, He X. TAGLN and High-mobility Group AT-Hook 2 (HMGA2) Complex Regulates TGF-β-induced Colorectal Cancer Metastasis. Onco Targets Ther. 2020;13:10489-10498 pubmed publisher
Li T, Peng R, Wang F, Hua L, Liu S, Han Z, et al. Lysophosphatidic acid promotes thrombus stability by inducing rapid formation of neutrophil extracellular traps: A new mechanism of thrombosis. J Thromb Haemost. 2020;18:1952-1964 pubmed publisher
Berg H, Ju Z, Myrvold M, Fasmer K, Halle M, Hoivik E, et al. Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma. Br J Cancer. 2020;122:1014-1022 pubmed publisher
Barrenas F, Raehtz K, Xu C, Law L, Green R, Silvestri G, et al. Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control. Nat Commun. 2019;10:5101 pubmed publisher
Hodson N, Patel S, Richardson S, Hoyland J, Gilbert H. Degenerate intervertebral disc-like pH induces a catabolic mechanoresponse in human nucleus pulposus cells. JOR Spine. 2018;1:e1004 pubmed publisher
Majumder S, Amatya N, Revu S, Jawale C, Wu D, Rittenhouse N, et al. IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival. Nat Immunol. 2019;20:534-545 pubmed publisher
Tseng C, Lai Y, Kuo T, Su J, Sung P, Feng C, et al. Rhodoptilometrin, a Crinoid-Derived Anthraquinone, Induces Cell Regeneration by Promoting Wound Healing and Oxidative Phosphorylation in Human Gingival Fibroblast Cells. Mar Drugs. 2019;17: pubmed publisher
Mi J, Hooker E, Balog S, Zeng H, Johnson D, He Y, et al. Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate. J Biol Chem. 2018;293:20123-20136 pubmed publisher
Ryu Y, Jin L, Kee H, Piao Z, Cho J, Kim G, et al. Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity. Sci Rep. 2016;6:34790 pubmed publisher
Menon S, Kakkar N, Radotra B. Expression of laminin and fibronectin in renal dysplasia. Pediatr Dev Pathol. 2004;7:568-76 pubmed
Plante E, Gaudreau M, Lachance D, Drolet M, Roussel E, Gauthier C, et al. Angiotensin-converting enzyme inhibitor captopril prevents volume overload cardiomyopathy in experimental chronic aortic valve regurgitation. Can J Physiol Pharmacol. 2004;82:191-9 pubmed
Berry S, Howard R, Akers R. Mammary localization and abundance of laminin, fibronectin, and collagen IV proteins in prepubertal heifers. J Dairy Sci. 2003;86:2864-74 pubmed
product information
Product Type :
Antibody
Product Name :
Fibronectin Monoclonal Antibody (FBN11)
Catalog # :
MA5-11981
Quantity :
500 µL
Price :
US 440.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human, Mouse, Rat
Applications :
Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1:500-1:5,000
Species :
Human, Mouse, Rat
Clone :
FBN11
Isotype :
IgG1
Storage :
4° C
Description :
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. Fibronectin is most abundant during embryonic development and tissue remodeling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin has been implicated in carcinoma development in lung cancer. Further, Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents. The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some Fibronectin variants has not been determined.
Immunogen :
Recombinant fibronectin protein
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1:500-1:5,000
Aliases :
Anastellin; CIG; Cold insoluble globulin (CIG); Cold-insoluble globulin; cumulus cell-specific fibronectin 1 transcript; DKFZp686F10164; DKFZp686H0342; DKFZp686I1370; DKFZp686O13149; E330027I09; ED-B; embryo-specific fibronectin 1 transcript; ferritin L subunit; ferritin L-chain; FIBNEC; fibronectin; fibronectin 1; fibronectin ED-A- region; fibronectin ED-B+ region; fibronectin variable region; FINC; FN; FN1; fn-1; FNZ; GFND; GFND2; LETS; LOW QUALITY PROTEIN: fibronectin; Migration stimulating factor (MSF); migration-stimulating factor; MSF; Ugl-Y1; Ugl-Y2; Ugl-Y3
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA