ErbB2 (HER-2) Antibody Cocktail | Invitrogen MA5-11976 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ErbB2 (HER-2) Antibody Cocktail

catalog :

MA5-11976

quantity :

500 µL

price :

US 456.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

L87, 2ERB19

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 21

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human immunohistochemistry; human western blot; human	Kuo H, Hsu S, Ou C, Li J, Tseng H, Chuang T, et al. Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway. Evid Based Complement Alternat Med. 2013;2013:219472 pubmed publisher
immunohistochemistry; human western blot; human	Mosoyan G, Nagi C, Marukian S, Teixeira A, Simonian A, Resnick Silverman L, et al. Multiple breast cancer cell-lines derived from a single tumor differ in their molecular characteristics and tumorigenic potential. PLoS ONE. 2013;8:e55145 pubmed publisher
western blot; human	Morancho B, Parra Palau J, Ibrahim Y, Bernadó Morales C, Peg V, Bech Serra J, et al. A dominant-negative N-terminal fragment of HER2 frequently expressed in breast cancers. Oncogene. 2013;32:1452-9 pubmed publisher
western blot; mouse	Sims A, Zweemer A, Nagumo Y, Faratian D, Muir M, Dodds M, et al. Defining the molecular response to trastuzumab, pertuzumab and combination therapy in ovarian cancer. Br J Cancer. 2012;106:1779-89 pubmed publisher
western blot; human; 0.5 ug/ml	Ghedini G, Ciravolo V, Tortoreto M, Giuffrè S, Bianchi F, Campiglio M, et al. Shed HER2 extracellular domain in HER2-mediated tumor growth and in trastuzumab susceptibility. J Cell Physiol. 2010;225:256-65 pubmed publisher
western blot; human	Peng J, Jordan V. Expression of estrogen receptor alpha with a Tet-off adenoviral system induces G0/G1 cell cycle arrest in SKBr3 breast cancer cells. Int J Oncol. 2010;36:451-8 pubmed
western blot; human	Barr D, Ostermeyer Fay A, Matundan R, Brown D. Clathrin-independent endocytosis of ErbB2 in geldanamycin-treated human breast cancer cells. J Cell Sci. 2008;121:3155-66 pubmed publisher
immunohistochemistry; human; 2 ug/ml	Lin C, Yen M, Lin C, Huang S, Yang H, Chow N, et al. Delivery of noncarrier naked DNA vaccine into the skin by supersonic flow induces a polarized T helper type 1 immune response to cancer. J Gene Med. 2008;10:679-89 pubmed publisher
western blot; human	Tsuda N, Chang D, Mine T, Efferson C, Garcia Sastre A, Wang X, et al. Taxol increases the amount and T cell activating ability of self-immune stimulatory multimolecular complexes found in ovarian cancer cells. Cancer Res. 2007;67:8378-87 pubmed
western blot; human	Jung Y, Xu W, Kim H, Ha N, Neckers L. Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin. Biochim Biophys Acta. 2007;1773:383-90 pubmed
western blot; human	Anido J, Scaltriti M, Bech Serra J, Santiago Josefat B, Todo F, Baselga J, et al. Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation. EMBO J. 2006;25:3234-44 pubmed
western blot; human	Liu P, Liu X, Li Y, Covington M, Wynn R, Huber R, et al. Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells. Cancer Biol Ther. 2006;5:657-64 pubmed
immunoprecipitation; human western blot; human	Hu P, Zhou T, Qian L, Wang J, Shi M, Yu M, et al. Sequestering ErbB2 in endoplasmic reticulum by its autoinhibitor from translocation to cell surface: an autoinhibition mechanism of ErbB2 expression. Biochem Biophys Res Commun. 2006;342:19-27 pubmed
western blot; human	Horak E, Heitner T, Robinson M, Simmons H, Garrison J, Russeva M, et al. Isolation of scFvs to in vitro produced extracellular domains of EGFR family members. Cancer Biother Radiopharm. 2005;20:603-13 pubmed
immunoprecipitation; human; 1 ug/time	Chan C, Metz M, Kane S. Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors. Breast Cancer Res Treat. 2005;91:187-201 pubmed
western blot; human	Nagy P, Friedlander E, Tanner M, Kapanen A, Carraway K, Isola J, et al. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res. 2005;65:473-82 pubmed
western blot; human	Xu W, Yuan X, Xiang Z, Mimnaugh E, Marcu M, Neckers L. Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex. Nat Struct Mol Biol. 2005;12:120-6 pubmed
	Lucchese A, Stevanovic S, Sinha A, Mittelman A, Kanduc D. Role of MHC II affinity and molecular mimicry in defining anti-HER-2/neu MAb-3 linear peptide epitope. Peptides. 2003;24:193-7 pubmed
	Shimizu H, Seiki T, Asada M, Yoshimatsu K, Koyama N. Alpha6beta1 integrin induces proteasome-mediated cleavage of erbB2 in breast cancer cells. Oncogene. 2003;22:831-9 pubmed
	Xu W, Marcu M, Yuan X, Mimnaugh E, Patterson C, Neckers L. Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu. Proc Natl Acad Sci U S A. 2002;99:12847-52 pubmed
	Mittelman A, Lucchese A, Sinha A, Kanduc D. Monoclonal and polyclonal humoral immune response to EC HER-2/NEU peptides with low similarity to the host's proteome. Int J Cancer. 2002;98:741-7 pubmed

image

image 1 :

product information

Product Type :

Antibody

Product Name :

ErbB2 (HER-2) Antibody Cocktail

Catalog # :

MA5-11976

Quantity :

500 µL

Price :

US 456.00

Clonality :

Cocktail

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 2 µg/mL, Western Blot: 0.5-1.0 µg/mL

Species :

Human

Clone :

L87, 2ERB19

Isotype :

IgG1

Storage :

4° C

Description :

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

Immunogen :

Extracellular domain of recombinant human c-erbB-2 oncoprotein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Western Blot: 0.5-1.0 µg/mL

Aliases :

avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); CD antigen CD340; CD340; c-erb B2/neu protein; c-erbB2; C-erbB-2; c-neu; epidermal growth factor receptor-related protein; erbb 2; ERBB2; erb-b2; Erbb-2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; erb-b2 receptor tyrosine kinase 2; her 2; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; Kiaa3023; metas; Metastatic lymph node gene 19 protein; mKIAA3023; MLN 19; MLN19; NEU; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

more info or order :

Invitrogen product webpage