NOTCH1 Monoclonal Antibody (A6) | Invitrogen MA5-11961 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NOTCH1 Monoclonal Antibody (A6)

catalog :

MA5-11961

quantity :

500 uL

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 22

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 7a	Zhang P, Ishikawa M, Doyle A, Nakamura T, He B, Yamada Y. Pannexin 3 regulates skin development via Epiprofin. Sci Rep. 2021;11:1779 pubmed publisher
immunohistochemistry; human; 1:500; fig 1	Mathan J, Ismail S, McGhee J, McGhee C, Sherwin T. Sphere-forming cells from peripheral cornea demonstrate the ability to repopulate the ocular surface. Stem Cell Res Ther. 2016;7:81 pubmed publisher
immunohistochemistry; human	Krausch M, Kroepil F, Lehwald N, Lachenmayer A, Schott M, Anlauf M, et al. Notch 1 tumor expression is lacking in highly proliferative pancreatic neuroendocrine tumors. Endocrine. 2013;44:182-6 pubmed publisher
blocking or activating experiments; human; 10 ug/ml	Del Papa B, Sportoletti P, Cecchini D, Rosati E, Balucani C, Baldoni S, et al. Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction. Eur J Immunol. 2013;43:182-7 pubmed publisher
flow cytometry; mouse	Perumalsamy L, Marcel N, Kulkarni S, Radtke F, Sarin A. Distinct spatial and molecular features of notch pathway assembly in regulatory T cells. Sci Signal. 2012;5:ra53 pubmed publisher
blocking or activating experiments; human; 20 ug/ml	Pei J, Tang Z, Zang G, Yu Y. Blockage of Notch1 signaling modulates the T-helper (Th)1/Th2 cell balance in chronic hepatitis B patients. Hepatol Res. 2010;40:799-805 pubmed publisher
flow cytometry; human; 1:100	Puget S, Grill J, Valent A, Bieche I, Dantas Barbosa C, Kauffmann A, et al. Candidate genes on chromosome 9q33-34 involved in the progression of childhood ependymomas. J Clin Oncol. 2009;27:1884-92 pubmed publisher
immunohistochemistry; human; 10-20 ug/ml	Kose O, Lalli A, Kutulola A, Odell E, Waseem A. Changes in the expression of stem cell markers in oral lichen planus and hyperkeratotic lesions. J Oral Sci. 2007;49:133-9 pubmed
immunocytochemistry; human ELISA; human	Luty W, Rodeberg D, Parness J, Vyas Y. Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. J Immunol. 2007;179:819-29 pubmed
immunohistochemistry; human; 1:100	Su Y, Buchler P, Gazdhar A, Giese N, Reber H, Hines O, et al. Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. J Gastrointest Surg. 2006;10:1230-41; discussion 1242 pubmed
western blot; mouse; 2 ug/ml	Bheeshmachar G, Purushotaman D, Sade H, Gunasekharan V, Rangarajan A, Sarin A. Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. J Immunol. 2006;177:5041-50 pubmed
immunohistochemistry; human	Blaukovitsch M, Halbwedl I, Kothmaier H, Gogg Kammerer M, Popper H. Sarcomatoid carcinomas of the lung--are these histogenetically heterogeneous tumors?. Virchows Arch. 2006;449:455-61 pubmed
immunohistochemistry; human; 1:100	Buchler P, Gazdhar A, Schubert M, Giese N, Reber H, Hines O, et al. The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. Ann Surg. 2005;242:791-800, discussion 800-1 pubmed
immunohistochemistry; human; 1:250	Morsczeck C, Gotz W, Schierholz J, Zeilhofer F, Kuhn U, Mohl C, et al. Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 2005;24:155-65 pubmed
immunohistochemistry; human; 1:200 western blot; human; 1:100	Purow B, Haque R, Noel M, Su Q, Burdick M, Lee J, et al. Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res. 2005;65:2353-63 pubmed
blocking or activating experiments; mouse	Sakamoto K, Chao W, Katsube K, Yamaguchi A. Distinct roles of EGF repeats for the Notch signaling system. Exp Cell Res. 2005;302:281-91 pubmed
	Yang H, Lee S, Berry B, Yang D, Zheng S, Carroll R, et al. A role for mutations in AK9 and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus. Proc Natl Acad Sci U S A. 2023;120:e2300681120 pubmed publisher
	Carrillo Tornel S, Chen Liang T, Zurdo M, Puiggros A, G xf3 mez Llon xed n A, Garc xed a Malo M, et al. NOTCH1 mutation in chronic lymphocytic leukaemia is associated with an enhanced cell cycle G1/S transition and specific cyclin overexpression: Preclinical ground for targeted inhibition. Br J Haematol. 2023;201:470-479 pubmed publisher
	Nasser S, Abdallah D, Ahmed K, Abdel Mottaleb Y, El Abhar H. The novel anti-colitic effect of β-adrenergic receptors via modulation of PS1/BACE-1/Aβ axis and NOTCH signaling in an ulcerative colitis model. Front Pharmacol. 2022;13:1008085 pubmed publisher
	Kim J, Han D, Byun S, Kwon M, Cho J, Pleasure S, et al. Ttyh1 regulates embryonic neural stem cell properties by enhancing the Notch signaling pathway. EMBO Rep. 2018;19: pubmed publisher
	Asano N, Watanabe T, Kitani A, Fuss I, Strober W. Notch1 signaling and regulatory T cell function. J Immunol. 2008;180:2796-804 pubmed
	Cui X, Hu Q, Tekaya M, Shimoda Y, Ang B, Nie D, et al. NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes. J Biol Chem. 2004;279:25858-65 pubmed

product information

Product Type :

Antibody

Product Name :

NOTCH1 Monoclonal Antibody (A6)

Catalog # :

MA5-11961

Quantity :

500 uL

Price :

US 480.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:20-1:200, Western Blot: 1:100-1:1,000

Species :

Human, Mouse

Clone :

Isotype :

IgG2b

Storage :

4 C

Description :

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).

Immunogen :

Recombinant protein encoding the ligand binding region of human Notch-1

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:20-1:200, Western Blot: 1:100-1:1,000

Aliases :

9930111A19Rik; AOS5; AOVD1; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); hN1; lin-12; major type A protein; Mis6; Motch; Motch A; mT14; N1; neurogenic locus notch homolog protein 1; NEXT; NICD; NOTCH; notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch gene homolog 1; Notch homolog 1, translocation-associated; notch receptor 1; Notch1; p300; RP23-306D20.12; RP23-306D20.12-001; Tan1; Translocation-associated notch protein TAN-1; transmembrane receptor Notch1

more info or order :

Invitrogen product webpage