Prolactin Receptor Monoclonal Antibody (B6.2) | Invitrogen MA5-11955 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Prolactin Receptor Monoclonal Antibody (B6.2)

catalog :

MA5-11955

quantity :

500 µL

price :

US 418

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

B6.2

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:200; fig 4 western blot; human; 1:2000; fig 4	Kim Y, Kim H, Yang D, Jung S, Noh M, Lee J, et al. Pineal Diffuse Large B-Cell Lymphoma Concomitant With Pituitary Prolactinoma: Possible Correlation Between 2 Distinguished Pathologies: A Case Report. Medicine (Baltimore). 2016;95:e2923 pubmed publisher
immunohistochemistry; human; 1:100	Bratthauer G, Strauss B, Barner R. Reversed Expression of the JAK/STAT Pathway Related Proteins Prolactin Receptor and STAT5a in Normal and Abnormal Breast Epithelial Cells. Breast Cancer (Auckl). 2008;1:7-14 pubmed
flow cytometry; human immunoprecipitation; human immunohistochemistry; human; 1:400	Bauernhofer T, Pichler M, Wieckowski E, Stanson J, Aigelsreiter A, Griesbacher A, et al. Prolactin receptor is a negative prognostic factor in patients with squamous cell carcinoma of the head and neck. Br J Cancer. 2011;104:1641-8 pubmed publisher
immunohistochemistry; human; 1:200	Tran Thanh D, Arneson N, Pintilie M, Deliallisi A, Warren K, Bane A, et al. Amplification of the prolactin receptor gene in mammary lobular neoplasia. Breast Cancer Res Treat. 2011;128:31-40 pubmed publisher
immunohistochemistry; human; 1:400 western blot; human; 1:1500	Harbaum L, Pollheimer M, Bauernhofer T, Kornprat P, Lindtner R, Schlemmer A, et al. Clinicopathological significance of prolactin receptor expression in colorectal carcinoma and corresponding metastases. Mod Pathol. 2010;23:961-71 pubmed publisher
immunocytochemistry; human; 1:100	Howell S, Anderson E, Hunter T, Farnie G, Clarke R. Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity. Breast Cancer Res. 2008;10:R68 pubmed publisher
immunohistochemistry; human; 1:1500	Ferreira M, Mesquita M, Quaresma M, Andre S. Prolactin receptor expression in gynaecomastia and male breast carcinoma. Histopathology. 2008;53:56-61 pubmed publisher
immunohistochemistry; human; 1:1000	Costa P, Catarino A, Silva F, Sobrinho L, Bugalho M. Expression of prolactin receptor and prolactin in normal and malignant thyroid: a tissue microarray study. Endocr Pathol. 2006;17:377-86 pubmed

image

image 1 :

Formalin-fixed, paraffin-embedded human breast cancer stained with Prolectin Receptor antibody using peroxidase-conjugate and AEC chromogen. Note cell membrane and cytoplasmic staining of tumor cells.

product information

Product Type :

Antibody

Product Name :

Prolactin Receptor Monoclonal Antibody (B6.2)

Catalog # :

MA5-11955

Quantity :

500 µL

Pricing :

US 418

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1-2 µg/mL

Species :

Human

Clone :

B6.2

Isotype :

IgG1

Storage :

4° C

Description :

Prolactin (PRL) is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor (PRLR), a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. PRLR consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.

Immunogen :

Semi-purified human prolactin receptor

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1-2 µg/mL

Aliases :

AI987712; cytokine receptor; HPRL; hPRL receptor; hPRLrI; Lactogen receptor; MFAB; pPRLR-SF; Pr-1; Pr-3; Prl R; PRLR; PRL-R; Prlr-rs1; Prolactin receptor; prolactin receptor 2 precursor; prolactin receptor related sequence 1; prolactin receptor short isoform; RATPRLR; secreted prolactin binding protein

more info or order :

Invitrogen product webpage