Bcl-xL Monoclonal Antibody (7D9) | Invitrogen MA5-11950 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Bcl-xL Monoclonal Antibody (7D9)

catalog :

MA5-11950

quantity :

500 µL

price :

US 430

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7D9

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; loading ...; fig 4d	Cho J, Lee J, Kim H, Lee H, Fang Z, Kwon H, et al. Ethyl Acetate Fraction of Amomum villosum var. xanthioides Attenuates Hepatic Endoplasmic Reticulum Stress-Induced Non-Alcoholic Steatohepatitis via Improvement of Antioxidant Capacities. Antioxidants (Basel). 2021;10: pubmed publisher
immunohistochemistry - paraffin section; rat; 1:100; loading ...; fig 5	Ahmed S, Othman N. The anti-cancer effects of Tualang honey in modulating breast carcinogenesis: an experimental animal study. BMC Complement Altern Med. 2017;17:208 pubmed publisher
immunohistochemistry; human; 1:200	Schneider S, Kloimstein P, Pammer J, Brannath W, Grasl M, Erovic B. New diagnostic markers in salivary gland tumors. Eur Arch Otorhinolaryngol. 2014;271:1999-2007 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100 immunohistochemistry; human; 1:100	Bradford C, Kumar B, Bellile E, Lee J, Taylor J, D SILVA N, et al. Biomarkers in advanced larynx cancer. Laryngoscope. 2014;124:179-87 pubmed publisher
immunohistochemistry; human; 1:1000	Erovic B, Kim D, Cassol C, Goldstein D, Irish J, Asa S, et al. Prognostic and predictive markers in medullary thyroid carcinoma. Endocr Pathol. 2012;23:232-42 pubmed publisher
immunohistochemistry; human; 1:1000	Erovic B, Harris L, Jamali M, Goldstein D, Irish J, Asa S, et al. Biomarkers of parathyroid carcinoma. Endocr Pathol. 2012;23:221-31 pubmed publisher
immunohistochemistry; human; 1:1000	Erovic B, Al Habeeb A, Harris L, Goldstein D, Kim D, Ghazarian D, et al. Identification of novel target proteins in sebaceous gland carcinoma. Head Neck. 2013;35:642-8 pubmed publisher
immunohistochemistry; human; 1:100	Eliassen A, Hauff S, Tang A, Thomas D, McHugh J, Walline H, et al. Head and neck squamous cell carcinoma in pregnant women. Head Neck. 2013;35:335-42 pubmed publisher
western blot; mouse	Hirai H, Verma M, Watanabe S, Tastad C, Asakura Y, Asakura A. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3. J Cell Biol. 2010;191:347-65 pubmed publisher
immunohistochemistry; human	Wildeman M, Gibcus J, Hauptmann M, Begg A, van Velthuysen M, Hoebers F, et al. Radiotherapy in laryngeal carcinoma: can a panel of 13 markers predict response?. Laryngoscope. 2009;119:316-22 pubmed publisher
immunohistochemistry; human	Kumar B, Cordell K, D SILVA N, Prince M, Adams M, Fisher S, et al. Expression of p53 and Bcl-xL as predictive markers for larynx preservation in advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg. 2008;134:363-9 pubmed publisher
immunohistochemistry; human	Bauer J, Kumar B, Cordell K, Prince M, Tran H, Wolf G, et al. Targeting apoptosis to overcome cisplatin resistance: a translational study in head and neck cancer. Int J Radiat Oncol Biol Phys. 2007;69:S106-8 pubmed
immunohistochemistry; human; 1:1000	Mita M, Ochoa L, Rowinsky E, Kuhn J, Schwartz G, Hammond L, et al. A phase I, pharmacokinetic and biologic correlative study of oblimersen sodium (Genasense, G3139) and irinotecan in patients with metastatic colorectal cancer. Ann Oncol. 2006;17:313-21 pubmed
immunohistochemistry; human; 1:75	Nix P, Cawkwell L, Patmore H, Greenman J, Stafford N. Bcl-2 expression predicts radiotherapy failure in laryngeal cancer. Br J Cancer. 2005;92:2185-9 pubmed
	Che S, Bie L, Li X, Qi H, Yu P, Zuo L. Parthenolide inhibits the proliferation and induces the apoptosis of human uveal melanoma cells. Int J Ophthalmol. 2019;12:1531-1538 pubmed publisher

image

image 1 :

Formalin-fixed, paraffin-embedded human Hodgkin’s lymphoma stained with Bcl-X antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of Hodgkin’s cells.

product information

Product Type :

Antibody

Product Name :

Bcl-xL Monoclonal Antibody (7D9)

Catalog # :

MA5-11950

Quantity :

500 µL

Pricing :

US 430

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 1 µg/test, Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Paraffin): 1:400, Immunoprecipitation: 2-4 µg

Species :

Human, Mouse

Clone :

7D9

Isotype :

IgG2a

Storage :

4° C

Description :

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

Immunogen :

A synthetic peptide corresponding to aa 35-50 (TEAPEETEAERETPSA) of mouse Bcl-xL protein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Paraffin): 1:400, Immunoprecipitation: 2-4 µg

Aliases :

anti-apoptosis regulatory protein; apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl(X)L; BCL2 like 1; Bcl2l; BCL2L1; bcl2-L-1; BCL2-like 1; Bcl-2-like protein 1; BCLX; bcl-x; BCLXL; Bcl-XL; BCL-XL/S; BCLXS; bcl-xS; Blc2l; DKFZp781P2092; EGK_02534; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; PPP1R52; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3

more info or order :

Invitrogen product webpage