PR3 Monoclonal Antibody (MCPR3-2) | Invitrogen MA5-11945 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PR3 Monoclonal Antibody (MCPR3-2)

catalog :

MA5-11945

quantity :

500 µL

price :

US 450.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MCPR3-2

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry

citations: 4

Reference
Chu T, Zheng G xe9 rard C, Huang K, Chang Y, Chen Y, I K, et al. GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation. Nat Commun. 2022;13:6385 pubmed publisher
Yang T, St John L, Garber H, Kerros C, Ruisaard K, Clise Dwyer K, et al. Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation. J Immunol. 2018;201:1389-1399 pubmed publisher
Alatrash G, Ono Y, Sergeeva A, Sukhumalchandra P, Zhang M, St John L, et al. The role of antigen cross-presentation from leukemia blasts on immunity to the leukemia-associated antigen PR1. J Immunother. 2012;35:309-20 pubmed publisher
Korkmaz B, Kuhl A, Bayat B, Santoso S, Jenne D. A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors. J Biol Chem. 2008;283:35976-82 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PR3 Monoclonal Antibody (MCPR3-2)

Catalog # :

MA5-11945

Quantity :

500 µL

Price :

US 450.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 1 µg/test, Immunocytochemistry: Assay-dependent, Western Blot: 1:50-1:500

Species :

Human, Mouse

Clone :

MCPR3-2

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt]

Immunogen :

HMC-1/PR3 cell granule extract

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Immunocytochemistry: Assay-dependent, Western Blot: 1:50-1:500

Aliases :

ACPA; AGP7; azurophil granule protein 7; CANCA; C-ANCA; C-ANCA antigen; leukocyte proteinase 3; MBN; MBT; mPR3; Myeloblastin; neutrophil proteinase 4; NP4; NP-4; P29; PR3; PR-3; Proteinase 3; PRTN3; serine proteinase, neutrophil; wegener autoantigen; Wegener granulomatosis autoantigen