This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
L-Plastin Monoclonal Antibody (LPL4A.1)
catalog :
MA5-11921
quantity :
500 µL
price :
US 496
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
LPL4A.1
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 12
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:300; loading ...; fig 1e
  • western blot; human; 1:300; loading ...; fig 1a, 1e
Tiedemann K, Sadvakassova G, Mikolajewicz N, Juhas M, Sabirova Z, Tabariès S, et al. Exosomal Release of L-Plastin by Breast Cancer Cells Facilitates Metastatic Bone Osteolysis. Transl Oncol. 2019;12:462-474 pubmed publisher
  • immunocytochemistry; human; fig 2
Van Audenhove I, Denert M, Boucherie C, Pieters L, Cornelissen M, Gettemans J. Fascin Rigidity and L-plastin Flexibility Cooperate in Cancer Cell Invadopodia and Filopodia. J Biol Chem. 2016;291:9148-60 pubmed publisher
  • western blot; human; fig 6
Lommel M, Trairatphisan P, Gäbler K, Laurini C, Muller A, Kaoma T, et al. L-plastin Ser5 phosphorylation in breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway. FASEB J. 2016;30:1218-33 pubmed publisher
  • western blot; human; 1 ug/ml
Riplinger S, Wabnitz G, Kirchgessner H, Jahraus B, Lasitschka F, Schulte B, et al. Metastasis of prostate cancer and melanoma cells in a preclinical in vivo mouse model is enhanced by L-plastin expression and phosphorylation. Mol Cancer. 2014;13:10 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
De Clercq S, Boucherie C, Vandekerckhove J, Gettemans J, Guillabert A. L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages. PLoS ONE. 2013;8:e78108 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
De Clercq S, Zwaenepoel O, Martens E, Vandekerckhove J, Guillabert A, Gettemans J. Nanobody-induced perturbation of LFA-1/L-plastin phosphorylation impairs MTOC docking, immune synapse formation and T cell activation. Cell Mol Life Sci. 2013;70:909-22 pubmed publisher
  • western blot; human; 1:2500
Gonzalez E, Neuhaus T, Kemper M, Girardin E. Proteomic analysis of mononuclear cells of patients with minimal-change nephrotic syndrome of childhood. Nephrol Dial Transplant. 2009;24:149-55 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
Harris L, De La Cerda J, Tuziak T, Rosen D, Xiao L, Shen Y, et al. Analysis of the expression of biomarkers in urinary bladder cancer using a tissue microarray. Mol Carcinog. 2008;47:678-85 pubmed publisher
  • immunohistochemistry; human
Klemke M, Rafael M, Wabnitz G, Weschenfelder T, Konstandin M, Garbi N, et al. Phosphorylation of ectopically expressed L-plastin enhances invasiveness of human melanoma cells. Int J Cancer. 2007;120:2590-9 pubmed
Sadvakassova G, Tiedemann K, Steer K, Mikolajewicz N, Stavnichuk M, In Kyung Lee I, et al. Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation. Physiol Rep. 2021;9:e14745 pubmed publisher
Wabnitz G, Balta E, Schindler S, Kirchgessner H, Jahraus B, Meuer S, et al. The pro-oxidative drug WF-10 inhibits serial killing by primary human cytotoxic T-cells. Cell Death Discov. 2016;2:16057 pubmed publisher
Sehnert B, Cavcic A, Böhm B, Kalden J, Nandakumar K, Holmdahl R, et al. Antileukoproteinase: modulation of neutrophil function and therapeutic effects on anti-type II collagen antibody-induced arthritis. Arthritis Rheum. 2004;50:2347-59 pubmed
product information
Product Type :
Antibody
Product Name :
L-Plastin Monoclonal Antibody (LPL4A.1)
Catalog # :
MA5-11921
Quantity :
500 µL
Price :
US 496
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human
Applications :
Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-3 µg/mL
Species :
Human
Clone :
LPL4A.1
Isotype :
IgG1
Storage :
4° C
Description :
L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calcium-binding domains. It gets phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosterones in androgen receptor positive prostrate and breast cancer cells through three androgen receptor binding elements located in the upstream region of the gene.
Immunogen :
Human recombinant L-plastin protein
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-3 µg/mL
Aliases :
65 kDa macrophage protein; AW536232; bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); CP64; D14Ertd310e; DKFZp781A23186; epididymis secretory protein Li 37; FLJ25423; FLJ26114; FLJ39956; HEL-S-37; LC64P; LCP1; LCP-1; L-fimbrin; LPL; L-PLASTIN; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65); L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); Lymphocyte cytosolic protein 1; lymphocyte cytosolic protein 1 (L-plastin); Lymphocyte cytosolic protein-1 (plasmin); plastin 2; plastin 2, L; plastin-2; Pls2; pp65
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA