CFTR Monoclonal Antibody (L12B4) | Invitrogen MA5-11763 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CFTR Monoclonal Antibody (L12B4)

catalog :

MA5-11763

quantity :

500 µL

price :

US 450

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

L12B4

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human	Hunter M, Treharne K, Winter A, Cassidy D, Land S, Mehta A. Expression of wild-type CFTR suppresses NF-kappaB-driven inflammatory signalling. PLoS ONE. 2010;5:e11598 pubmed publisher
immunocytochemistry; human; 1:500 western blot; human; 1:1000	Ajonuma L, Fok K, Ho L, Chan P, Chow P, Tsang L, et al. CFTR is required for cellular entry and internalization of Chlamydia trachomatis. Cell Biol Int. 2010;34:593-600 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CFTR Monoclonal Antibody (L12B4)

Catalog # :

MA5-11763

Quantity :

500 µL

Price :

US 450

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunofluorescence: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Species :

Human, Mouse, Rat

Clone :

L12B4

Isotype :

IgG1

Storage :

4° C

Description :

Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.

Immunogen :

Recombinant protein encoding NBF1 domain of human CFTR

Format :

Liquid

Applications w/Dilutions :

Immunofluorescence: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Aliases :

ABC35; Abcc7; ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; ATP-binding cassette, subfamily c, member 7; AW495489; cAMP-dependent chloride channel; CF; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7; dJ760C5.1; MRP7; RGD1561193; tcag7.78; TNR-CFTR