Factor XIII A Monoclonal Antibody (AC-1A1) | Invitrogen MA5-11751 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Factor XIII A Monoclonal Antibody (AC-1A1)

catalog :

MA5-11751

quantity :

500 µL

price :

US 437

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AC-1A1

reactivity :

human, pigs

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:1000; tbl 2	Cullen D, Diaz Recuero J, Cullen R, Rodriguez Peralto J, Kutzner H, Requena L. Superficial Acral Fibromyxoma: Report of 13 Cases With New Immunohistochemical Findings. Am J Dermatopathol. 2017;39:14-22 pubmed publisher
immunohistochemistry - paraffin section; human; 1:300	Peroni A, Colato C, Schena D, Rongioletti F, Girolomoni G. Histiocytoid Sweet syndrome is infiltrated predominantly by M2-like macrophages. J Am Acad Dermatol. 2015;72:131-9 pubmed publisher
immunohistochemistry; human; 1:100	Tasli F, Vardar E, Argon A, Kabat T, Deniz S, Nart A, et al. Histochemical and immunohistochemical characteristics of elastofibromas. Pol J Pathol. 2014;65:120-4 pubmed
western blot; human	Abaeva A, Canault M, Kotova Y, Obydennyy S, Yakimenko A, Podoplelova N, et al. Procoagulant platelets form an ?-granule protein-covered "cap" on their surface that promotes their attachment to aggregates. J Biol Chem. 2013;288:29621-32 pubmed publisher
immunohistochemistry; human; 1:1000	Mentzel T, Wiesner T, Cerroni L, Hantschke M, Kutzner H, Rutten A, et al. Malignant dermatofibroma: clinicopathological, immunohistochemical, and molecular analysis of seven cases. Mod Pathol. 2013;26:256-67 pubmed publisher
immunohistochemistry; human; 1:1000	Kutzner H, Mentzel T, Palmedo G, Hantschke M, Rutten A, Paredes B, et al. Plaque-like CD34-positive dermal fibroma ("medallion-like dermal dendrocyte hamartoma"): clinicopathologic, immunohistochemical, and molecular analysis of 5 cases emphasizing its distinction from superficial, plaque-like dermatofibrosarcoma. Am J Surg Pathol. 2010;34:190-201 pubmed publisher
immunohistochemistry; human; 1:300	Miserus R, Herias M, Prinzen L, Lobbes M, van Suylen R, Dirksen A, et al. Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agent. JACC Cardiovasc Imaging. 2009;2:987-96 pubmed publisher
immunohistochemistry; pigs	Huebner J, Johnson K, Kraus V, Terkeltaub R. Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA. Osteoarthritis Cartilage. 2009;17:1056-64 pubmed publisher
immunohistochemistry; human; 1:1000	Mentzel T, Kutzner H. Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm. Am J Dermatopathol. 2009;31:44-9 pubmed publisher
immunohistochemistry; human	Zaba L, Fuentes Duculan J, Steinman R, Krueger J, Lowes M. Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages. J Clin Invest. 2007;117:2517-25 pubmed
immunohistochemistry; human western blot; human	Nakano Y, Al Jallad H, Mousa A, Kaartinen M. Expression and localization of plasma transglutaminase factor XIIIA in bone. J Histochem Cytochem. 2007;55:675-85 pubmed
immunohistochemistry; human; 1:50	Elpek G, Küpesiz G, Ogus M. Incidental calcifying fibrous tumor of the stomach presenting as a polyp. Pathol Int. 2006;56:227-31 pubmed
immunohistochemistry; human; 1:500	Lohwasser C, Neureiter D, Weigle B, Kirchner T, Schuppan D. The receptor for advanced glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alpha. J Invest Dermatol. 2006;126:291-9 pubmed
immunocytochemistry; human immunohistochemistry; human western blot; human	Mehta K. Mammalian transglutaminases: a family portrait. Prog Exp Tumor Res. 2005;38:1-18 pubmed
	Tavares Gomes L, Monney C, Neuhaus G, Francisco D, Solis D, Summerfield A, et al. Transcriptome of microglia reveals a species-specific expression profile in bovines with conserved and new signature genes. Glia. 2021;69:1932-1949 pubmed publisher

image

image 1 :

Formalin-fixed, paraffin-embedded human placenta stained with Factor XIIIa antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of fibroblasts and macrophages

image 2 :

product information

Product Type :

Antibody

Product Name :

Factor XIII A Monoclonal Antibody (AC-1A1)

Catalog # :

MA5-11751

Quantity :

500 µL

Pricing :

US 437

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:25-1:50

Species :

Human

Clone :

AC-1A1

Isotype :

IgG1, kappa

Storage :

4° C

Description :

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

Immunogen :

Recombinant protein corresponding to A-subunit of coagulation Factor XIII

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:25-1:50

Aliases :

1200014I03Rik; AI462306; bA525O21.1 (coagulation factor XIII, A1 polypeptide); coagulation factor XIII A chain; coagulation factor XIII, A polypeptide; coagulation factor XIII, A1 polypeptide; coagulation factor XIII, A1 subunit; coagulation factor XIII, alpha subunit; coagulation factor XIIIa; F13A; F13a1; factor viiia; Factor XIIIA; fibrin stabilizing factor, A subunit; fibrinoligase; FSF, A subunit; protein-glutamine gamma-glutamyltransferase A chain; RP11-232H4.1; TGase; transglutaminase A chain; transglutaminase. plasma

more info or order :

Invitrogen product webpage