beta Tubulin Monoclonal Antibody (TBN06 (Tub 2.5)) | Invitrogen MA5-11732 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

beta Tubulin Monoclonal Antibody (TBN06 (Tub 2.5))

catalog :

MA5-11732

quantity :

500 µL

price :

US 439

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TBN06 (Tub 2.5)

reactivity :

human, mouse, rat, chicken, bovine, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 27

Reference
Lima D, Silva L, Comizzoli P. Influence of warming and reanimation conditions on seminiferous tubule morphology, mitochondrial activity, and cell composition of vitrified testicular tissues in the domestic cat model. PLoS ONE. 2018;13:e0207317 pubmed publisher
Wu L, Zhang X, Zhao L. Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention. J Neurosci. 2018;38:6665-6681 pubmed publisher
Zhang C, Han X, Xu X, Zhou Z, Chen X, Tang Y, et al. FoxM1 drives ADAM17/EGFR activation loop to promote mesenchymal transition in glioblastoma. Cell Death Dis. 2018;9:469 pubmed publisher
Ittig S, Schmutz C, Kasper C, Amstutz M, Schmidt A, Sauteur L, et al. A bacterial type III secretion-based protein delivery tool for broad applications in cell biology. J Cell Biol. 2015;211:913-31 pubmed publisher
Rouvinski A, Karniely S, Kounin M, Moussa S, Goldberg M, Warburg G, et al. Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs. J Cell Biol. 2014;204:423-41 pubmed publisher
Stockwell S, Platt G, Barrie S, Zoumpoulidou G, te Poele R, Aherne G, et al. Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling. PLoS ONE. 2012;7:e28568 pubmed publisher
Olmstead A, Knecht W, Lazarov I, Dixit S, Jean F. Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents. PLoS Pathog. 2012;8:e1002468 pubmed publisher
Berezniuk I, Vu H, Lyons P, Sironi J, Xiao H, Burd B, et al. Cytosolic carboxypeptidase 1 is involved in processing ?- and ?-tubulin. J Biol Chem. 2012;287:6503-17 pubmed publisher
Chae H, Lee M, Broxmeyer H. 5-Aminoimidazole-4-carboxyamide ribonucleoside induces G(1)/S arrest and Nanog downregulation via p53 and enhances erythroid differentiation. Stem Cells. 2012;30:140-9 pubmed publisher
Amor I, Rauch F, Gruenwald K, Weis M, Eyre D, Roughley P, et al. Severe osteogenesis imperfecta caused by a small in-frame deletion in CRTAP. Am J Med Genet A. 2011;155A:2865-70 pubmed publisher
Xu D, Kishi H, Kawamichi H, Kajiya K, Takada Y, Kobayashi S. Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts. Cell Signal. 2012;24:282-9 pubmed publisher
Kunoh T, Noda T, Koseki K, Sekigawa M, Takagi M, Shin ya K, et al. A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells. Mol Cancer Ther. 2010;9:2934-42 pubmed publisher
Delord J, Quideau S, Rochaix P, Caselles O, Couderc B, Hennebelle I, et al. Trastuzumab induced in vivo tissue remodelling associated in vitro with inhibition of the active forms of AKT and PTEN and RhoB induction in an ovarian carcinoma model. Br J Cancer. 2010;103:61-72 pubmed publisher
Hoshino S, Konishi M, Mori M, Shimura M, Nishitani C, Kuroki Y, et al. HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency. J Leukoc Biol. 2010;87:1133-43 pubmed publisher
Chiu L, Ko J, Lee Y, Yang T, Tee Y, Sheu G. L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett. 2010;192:408-18 pubmed publisher
Blom T, Fox H, Angers Loustau A, Peltonen K, Kerosuo L, Wartiovaara K, et al. KIT overexpression induces proliferation in astrocytes in an imatinib-responsive manner and associates with proliferation index in gliomas. Int J Cancer. 2008;123:793-800 pubmed publisher
Haga S, Yamamoto N, Nakai Murakami C, Osawa Y, Tokunaga K, Sata T, et al. Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry. Proc Natl Acad Sci U S A. 2008;105:7809-14 pubmed publisher
Ye L, Dong N, Wang Q, Xu Z, Cai N, Wang H, et al. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. Intervirology. 2008;51:50-8 pubmed publisher
Hiroi Y, Guo Z, Li Y, Beggs A, Liao J. Dynamic regulation of endothelial NOS mediated by competitive interaction with alpha-actinin-4 and calmodulin. FASEB J. 2008;22:1450-7 pubmed publisher
Petersson S, Bylander A, Yhr M, Enerback C. S100A7 (Psoriasin), highly expressed in ductal carcinoma in situ (DCIS), is regulated by IFN-gamma in mammary epithelial cells. BMC Cancer. 2007;7:205 pubmed
Stein E, Blaimauer K, Bauer S, Erovic B, Turhani D, Thurnher D. High expression of integrin beta1 correlates with high proliferation capacity in oral keratinocytes. Wien Klin Wochenschr. 2007;119:318-22 pubmed
Pecciarini L, Cangi M, Lo Cunsolo C, Macri E, Dal Cin E, Martignoni G, et al. Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient. Genes Chromosomes Cancer. 2007;46:419-26 pubmed
Chou H, Chou H, Lee S. CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10). J Biol Chem. 2006;281:15201-7 pubmed
Barker C, Hamlett J, Pennington S, Burrows F, Lundgren K, Lough R, et al. The topoisomerase II-Hsp90 complex: a new chemotherapeutic target?. Int J Cancer. 2006;118:2685-93 pubmed
Tsai C, Van Der Weele C, Wolniak S. Differential segregation and modification of mRNA during spermiogenesis in Marsilea vestita. Dev Biol. 2004;269:319-30 pubmed
Balachandran R, Welsh M, Day B. Altered levels and regulation of stathmin in paclitaxel-resistant ovarian cancer cells. Oncogene. 2003;22:8924-30 pubmed
Lu K, Jong K, Rajasekaran A, Cloughesy T, Mischel P. Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line. Lab Invest. 2004;84:8-20 pubmed

product information

Product Type :

Antibody

Product Name :

beta Tubulin Monoclonal Antibody (TBN06 (Tub 2.5))

Catalog # :

MA5-11732

Quantity :

500 µL

Price :

US 439

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Amphibian, Bovine, Chicken, Human, Insect, Mouse, Plant, Rabbit, Rat

Applications :

Immunocytochemistry: 1:50-1:200, Immunofluorescence: 1:50-1:200, Immunohistochemistry (Paraffin): 1-2 µg/mL, Western Blot: 0.5-1.0 µg/mL

Species :

Amphibian, Bovine, Chicken, Human, Insect, Mouse, Plant, Rabbit, Rat

Clone :

TBN06 (Tub 2.5)

Isotype :

IgG3

Storage :

4° C

Description :

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance and maintenance. Mutations in the beta tubulin gene are the cause of congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues. Glutamate residues at the C-terminus of beta III tubulin can be glutamylated. The precise function of such modifications is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression. Ser-172 phosphorylation inhibits tubulin incorporation into microtubules.Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of Tubulin, which is a dimer of two 55 kDa subunits: alpha and Beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for assays involving protein detection, such as Western blotting.

Immunogen :

Purified tubulin

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:200, Immunofluorescence: 1:50-1:200, Immunohistochemistry (Paraffin): 1-2 µg/mL, Western Blot: 0.5-1.0 µg/mL

Aliases :

2310057H16Rik; 2810484G07Rik; 3200002H15Rik; AA408537; AI325297; AI596182; B130022C14Rik; bA631M21.2; BB220206; beta 5-tubulin; beta Ib tubulin; beta tubulin; beta tubulin 1; beta-4; beta-4 tubulin; beta-4-tubulin; beta-5; beta-5 tubulin; beta5-tubulin; betaIII-tubulin; beta-tubulin class-III; Beta-tubulin class-V; beta-tubulin class-VI; Beta-tubulin isotype I; c(beta)7 tubulin; CDCBM; CDCBM1; CDCBM5; CDCBM6; CFEOM3; CFEOM3A; class I beta tubulin; Class I beta-tubulin; class IIa beta-tubulin; class III beta-tubulin; class IVa beta-tubulin; class V beta tubulin; class V beta-tubulin; CSCSC1; dJ40E16.7; dystonia 4, torsion (autosomal dominant); DYT4; FEOM3; HSA10p15 beta-tubulin 4Q; HsT1601; hypothetical protein LOC540236; hypothetical protein LOC550458; I79_000194; I79_012097; LOC100347858; LOC100358689; LOC100761889; LOW QUALITY PROTEIN: tubulin beta-6 chain; M(beta)1; M(beta)2; M(beta)3; M(beta)4; M(beta)5; M(beta)6; M40; M40 antibody; MGC128415 protein; MGC137802 protein; neuron-specific class III beta-tubulin; OK/SW-cl.56; OOMD; OOMD2; RGD1305887; si:ch211-122i22.4; si:ch211-9a18.2; Tubb; tubb beta-5; tubb.L; Tubb1; Tubb2; TUBB2A; tubb2a {ECO:0000250; TUBB3; TUBB4; Tubb4a; Tubb5; TUBB-5; Tubb6; TUBB8; Tubulin 5 beta; tubulin beta; tubulin beta 1 class VI; tubulin beta 2A class IIa; tubulin beta 3 class III; tubulin beta 4'; tubulin beta 4A class IVa; tubulin beta 6 class V; tubulin beta 8 class VIII; Tubulin beta chain; tubulin beta class I; tubulin beta class I L homeolog; Tubulin beta class IIa; Tubulin beta class V; tubulin beta MGC4083; tubulin beta-1; Tubulin beta-1 chain; tubulin beta-2A chain; tubulin beta-2B chain; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin beta-4A chain; tubulin beta-5 chain; Tubulin beta-6 chain; tubulin beta-7 chain; Tubulin beta-8 chain; tubulin beta-III; tubulin, beta 1 class VI; tubulin, beta 1-like; tubulin, beta 2; tubulin, beta 2A; tubulin, beta 2A class IIa; tubulin, beta 3; tubulin, beta 3 class III; tubulin, beta 4; tubulin, beta 4 class IVa; tubulin, beta 4A class IVa; tubulin, beta 5; tubulin, beta 5 class I; tubulin, beta 5-like; tubulin, beta 6 class V; tubulin, beta class I; tubulin, beta family 1; tubulin, beta polypeptide; tubulin, beta polypeptide 2; tubulin, beta, 3; tubulin, beta, 4; tubulin, beta, 5; uncharacterized protein LOC550458; UniProtKB:Q7TMM9}; Unknown (protein for MGC:134115); XELAEV_18039222mg; XLOT; zbetaI; zgc:112515