Mast Cell Chymase Monoclonal Antibody (CC1) | Invitrogen MA5-11717 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Mast Cell Chymase Monoclonal Antibody (CC1)

catalog :

MA5-11717

quantity :

500 µL

price :

US 436

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CC1

reactivity :

human, rat, dogs

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; rat; fig 4	Ali Q, Patel S, Hussain T. Angiotensin AT2 receptor agonist prevents salt-sensitive hypertension in obese Zucker rats. Am J Physiol Renal Physiol. 2015;308:F1379-85 pubmed publisher
immunocytochemistry; human	Ningyan G, Xu Y, Hongfei S, Jingjing C, Min C. The role of macrophage migration inhibitory factor in mast cell-stimulated fibroblast proliferation and collagen production. PLoS ONE. 2015;10:e0122482 pubmed publisher
immunohistochemistry; human; 1:750 ELISA; human; 1:1000	Wasse H, Rivera A, Huang R, Martinson D, Long Q, McKinnon W, et al. Increased plasma chymase concentration and mast cell chymase expression in venous neointimal lesions of patients with CKD and ESRD. Semin Dial. 2011;24:688-93 pubmed publisher
immunohistochemistry; human	Matsuda A, Okayama Y, Ebihara N, Yokoi N, Hamuro J, Walls A, et al. Hyperexpression of the high-affinity IgE receptor-beta chain in chronic allergic keratoconjunctivitis. Invest Ophthalmol Vis Sci. 2009;50:2871-7 pubmed publisher
immunohistochemistry; human	Trani N, Bonetti L, Gualandri G, Barbolini G. Immediate anaphylactic death following antibiotics injection: splenic eosinophilia easily revealed by pagoda red stain. Forensic Sci Int. 2008;181:21-5 pubmed publisher
immunohistochemistry; human; 1 ug/ml	Buckley M, Walls A. Identification of mast cells and mast cell subpopulations. Methods Mol Med. 2008;138:285-97 pubmed publisher
western blot; rat; 1:250	De Filippis D, Russo A, D Amico A, Esposito G, Pietropaolo C, Concetta P, et al. Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5. Br J Pharmacol. 2008;154:1672-9 pubmed publisher
immunohistochemistry; rat; 1:100	Hinescu M, Popescu L, Gherghiceanu M, Faussone Pellegrini M. Interstitial Cajal-like cells in rat mesentery: an ultrastructural and immunohistochemical approach. J Cell Mol Med. 2008;12:260-70 pubmed publisher
immunohistochemistry; rat; 1:100	Popescu L, Gherghiceanu M, Hinescu M, Cretoiu D, Ceafalan L, Regalia T, et al. Insights into the interstitium of ventricular myocardium: interstitial Cajal-like cells (ICLC). J Cell Mol Med. 2006;10:429-58 pubmed
immunohistochemistry; human	Fukiwake N, Moroi Y, Imafuku S, Masuda T, Kokuba H, Furue M, et al. Anti-CXCR3 staining is useful for detecting human cutaneous and mucosal mast cells. J Dermatol. 2006;33:326-30 pubmed
immunohistochemistry; dogs; 1:500	Fernandez N, West K, Jackson M, Kidney B. Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors. Vet Pathol. 2005;42:437-45 pubmed
immunohistochemistry; human	Edwards S, Cruz A, Donnelly S, Dazin P, Schulman E, Jones K, et al. c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseases. J Pathol. 2005;206:279-90 pubmed

product information

Product Type :

Antibody

Product Name :

Mast Cell Chymase Monoclonal Antibody (CC1)

Catalog # :

MA5-11717

Quantity :

500 µL

Price :

US 436

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:2000, Western Blot: Assay Dependent

Species :

Human

Clone :

CC1

Isotype :

IgG1

Storage :

4° C

Description :

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11. 2 in a cluster of genes encoding other proteases.

Immunogen :

Purified human skin chymase

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:2000, Western Blot: Assay Dependent

Aliases :

Alpha-chymase; chymase; chymase 1; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I; chymase 1, mast cell; chymase, heart; chymase, mast cell; Cma1; CYH; CYM; mast cell; Mast cell chymase 1; mast cell protease 3; Mast cell protease 5; mast cell protease I; Mast cell protease III; MCP3P; Mcp5; Mcp-5; Mcpt3; Mcpt5; MCT1; MMCP-5; rMCP-3; rMCP-5; rMCP-III