This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Survivin Monoclonal Antibody (8E2)
catalog :
MA5-11680
quantity :
500 uL
price :
US 474.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
8.00E+02

The same clone is also sold as:
reactivity :
human, rat
application :
immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 15
Reference
Li H, Gong J, Jiang X, Shao H. Arsenic trioxide treatment of rabbit liver VX-2 carcinoma via hepatic arterial cannulation-induced apoptosis and decreased levels of survivin in the tumor tissue. Croat Med J. 2013;54:12-6 pubmed
Mazzarella T, Cambiaghi V, Rizzo N, Pilla L, Parolini D, Orsenigo E, et al. Ex vivo enrichment of circulating anti-tumor T cells from both cutaneous and ocular melanoma patients: clinical implications for adoptive cell transfer therapy. Cancer Immunol Immunother. 2012;61:1169-82 pubmed publisher
da Cunha I, De Brot L, Carvalho K, Rocha R, Fregnani J, Falzoni R, et al. Prognostication of soft tissue sarcomas based on chromosome 17q gene and protein status: evaluation of TOP2A, HER-2/neu, and survivin. Ann Surg Oncol. 2012;19:1790-9 pubmed publisher
Fan Y, Zhao Z, Fu J, Chen C, Sun W. Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo. Hepatobiliary Pancreat Dis Int. 2010;9:414-22 pubmed
Di Tomaso T, Mazzoleni S, Wang E, Sovena G, Clavenna D, Franzin A, et al. Immunobiological characterization of cancer stem cells isolated from glioblastoma patients. Clin Cancer Res. 2010;16:800-13 pubmed publisher
Zeng S, Li Y, Jin Y, Zhang Q, Keller D, McQuaw C, et al. Structure-specific recognition protein 1 facilitates microtubule growth and bundling required for mitosis. Mol Cell Biol. 2010;30:935-47 pubmed publisher
Lööf J, Pfeifer D, Adell G, Sun X. Significance of an exon 2 G4C14-to-A4T14 polymorphism in the p73 gene on survival in rectal cancer patients with or without preoperative radiotherapy. Radiother Oncol. 2009;92:215-20 pubmed publisher
Wang C, Zhou Z, Holmqvist A, Zhang H, Li Y, Adell G, et al. Survivin expression quantified by Image Pro-Plus compared with visual assessment. Appl Immunohistochem Mol Morphol. 2009;17:530-5 pubmed publisher
Koch B, Basu Baul T, Chatterjee A. p53-dependent antiproliferative and antitumor effect of novel alkyl series of diorganotin(IV) compounds. Invest New Drugs. 2009;27:319-26 pubmed publisher
Flynn C, Montrose D, Swank D, Nakanishi M, Ilsley J, Rosenberg D. Deoxycholic acid promotes the growth of colonic aberrant crypt foci. Mol Carcinog. 2007;46:60-70 pubmed
Lee W, Su W, Lin P, Guo H, Chang T, Chen H. Expression of S100A4 and Met: potential predictors for metastasis and survival in early-stage breast cancer. Oncology. 2004;66:429-38 pubmed
Kami K, Doi R, Koizumi M, Toyoda E, Mori T, Ito D, et al. Survivin expression is a prognostic marker in pancreatic cancer patients. Surgery. 2004;136:443-8 pubmed
Sommer K, Schamberger C, Schmidt G, Sasgary S, Cerni C. Inhibitor of apoptosis protein (IAP) survivin is upregulated by oncogenic c-H-Ras. Oncogene. 2003;22:4266-80 pubmed
Das A, Tan W, Smith D. Expression of the inhibitor of apoptosis protein survivin in benign meningiomas. Cancer Lett. 2003;193:217-23 pubmed
Das A, Tan W, Teo J, Smith D. Expression of survivin in primary glioblastomas. J Cancer Res Clin Oncol. 2002;128:302-6 pubmed
product information
Product Type :
Antibody
Product Name :
Survivin Monoclonal Antibody (8E2)
Catalog # :
MA5-11680
Quantity :
500 uL
Price :
US 474.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human, Rat
Applications :
Immunocytochemistry: 1:10-1:200, Immunohistochemistry (Paraffin): 1:10-1:100
Species :
Human, Rat
Clone :
8.00E+02
Isotype :
IgG1, kappa
Storage :
4 C
Description :
Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family. The IAPs are involved in multiple cell functions such as cell signaling, cell division, metabolism, and exhibits differential expression in nearly all human cancers, but not in most normal tissues. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but the Survivin gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of survivin’s gene expression. Survivin is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. Survivin may counteract a default induction of apoptosis in G2/M phase. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.
Immunogen :
Full length recombinant human survivin protein
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:10-1:200, Immunohistochemistry (Paraffin): 1:10-1:100
Aliases :
AAC-11; AP14; Api4; apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat containing 5; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; EPR 1; EPR-1; Iap4; inhibitor of apoptosis; survivin; survivin variant 3 alpha; survivin40; SVV; TIAP
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA