CD42b Monoclonal Antibody (42C01) | Invitrogen MA5-11642 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD42b Monoclonal Antibody (42C01)

catalog :

MA5-11642

quantity :

500 µL

price :

US 450

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

42C01

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1a	Staessens S, Denorme F, Francois O, Desender L, Dewaele T, Vanacker P, et al. Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance. Haematologica. 2019;: pubmed publisher
immunocytochemistry; human	Passam F, Rahgozar S, Qi M, Raftery M, Wong J, Tanaka K, et al. Redox control of ?2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1. J Thromb Haemost. 2010;8:1754-62 pubmed publisher
	Pir G, Parray A, Ayadathil R, Pananchikkal S, Mir F, Muhammad I, et al. Platelet-Neutrophil Association in NETs-Rich Areas in the Retrieved AIS Patient Thrombi. Int J Mol Sci. 2022;23: pubmed publisher
	Skyrman S, Burstr xf6 m G, Aspegren O, Babic D, Lucassen G, Edstr xf6 m E, et al. Clot composition characterization using diffuse reflectance spectroscopy in acute ischemic stroke. Biomed Opt Express. 2022;13:3311-3323 pubmed publisher
	M Ravindra V, Denorme F, D Alexander M, A Campbell R, Grandhi R. Endovascular mechanical thrombectomy in a child with COVID-19: Clot analysis reveals a novel pathway in the neuroinflammatory cascade resulting in large-vessel occlusion. Interv Neuroradiol. 2022;:15910199221094758 pubmed publisher
	Essig F, Babilon L, Vollmuth C, Kollikowski A, Pham M, Solymosi L, et al. High Mobility Group Box 1 Protein in Cerebral Thromboemboli. Int J Mol Sci. 2021;22: pubmed publisher
	Huang K, Ko T, Hung C, Chu J, Wang A, Chiou S. Crystal structure of a platelet-agglutinating factor isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus). Biochem J. 2004;378:399-407 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD42b Monoclonal Antibody (42C01)

Catalog # :

MA5-11642

Quantity :

500 µL

Price :

US 450

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 2 µg/test, Immunohistochemistry (Paraffin): 1-2 µg/mL

Species :

Human

Clone :

42C01

Isotype :

IgG1

Storage :

4° C

Description :

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Immunogen :

Recombinant CD42b

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 2 µg/test, Immunohistochemistry (Paraffin): 1-2 µg/mL

Aliases :

antigen CD42b-alpha; BDPLT1; BDPLT3; BSS; CD42a; CD42B; CD42b-alpha; DBPLT3; Glycocalicin; glycoprotein 1b, alpha polypeptide; glycoprotein Ib (platelet), alpha polypeptide; glycoprotein Ib platelet alpha subunit; glycoprotein Ib platelet subunit alpha; glycoprotein Ibalpha; GP1B; GP1BA; GPIB; GPIb alpha; GP-Ib alpha; GPIbA; GPIbalpha; GPIX; GP-IX; MGC34595; mutant platelet membrane glycoprotein Ib-alpha; Platelet glycoprotein Ib alpha chain; platelet glycoprotein Ib alpha polypeptide; Platelet GPIX; platelet membrane glycoprotein 1b-alpha subunit; platelet membrane glycoprotein Ib-alpha; VWDP