SRC2 Monoclonal Antibody (GRP01) | Invitrogen MA5-11553 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SRC2 Monoclonal Antibody (GRP01)

catalog :

MA5-11553

quantity :

500 uL

price :

US 474.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

GRP01

The same clone is also sold as:

Abcam: ab44970

reactivity :

human

application :

western blot, immunoprecipitation

citations: 1

Reference
Liu D, Kang J, Derynck R. TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J. 2004;23:1557-66 pubmed

product information

Product Type :

Antibody

Product Name :

SRC2 Monoclonal Antibody (GRP01)

Catalog # :

MA5-11553

Quantity :

500 uL

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Immunoprecipitation: 2 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human

Clone :

GRP01

Isotype :

IgG1, kappa

Storage :

4 C

Description :

SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator2, NCOA2 or TIF2, aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors, are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation.

Immunogen :

Recombinant human GRIP1 protein

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: 2 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

bHLHe75; c-fgr; Class E basic helix-loop-helix protein 75; c-src2; D1Ertd433e; FLJ43153; Glucocorticoid receptor-interacting protein 1; glucocorticoid receptor-interacting protein-1; Grip1; GRIP-1; hTIF2; I79_019839; KAT13C; MGC75096; NCOA2; NCoA-2; Nuclear receptor coactivator 2; p160 steroid receptor coactivator 2; p55c-fgr; p58c-fgr; SRC2; SRC-2; Steroid receptor coactivator 2; TIF 2; Tif2; transcriptional intermediary factor 2