GnRHR Monoclonal Antibody (GNRH03) | Invitrogen MA5-11538 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GnRHR Monoclonal Antibody (GNRH03)

catalog :

MA5-11538

quantity :

500 µL

price :

US 419

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

GNRH03

reactivity :

human, rat

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:100	Sakai M, Martinez Arguelles D, Patterson N, Chaurand P, Papadopoulos V. In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonist degarelix on human prostate cell growth. PLoS ONE. 2015;10:e0120670 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100	Li Q, Coulson H, Klaassen Z, Sharma S, Ramalingam P, Moses K, et al. Emerging association between androgen deprivation therapy and male meningioma: significant expression of luteinizing hormone-releasing hormone receptor in male meningioma. Prostate Cancer Prostatic Dis. 2013;16:387-90 pubmed publisher
western blot; human	Ling Poon S, Lau M, Hammond G, Leung P. Gonadotropin-releasing hormone-II increases membrane type I metalloproteinase production via beta-catenin signaling in ovarian cancer cells. Endocrinology. 2011;152:764-72 pubmed publisher
immunohistochemistry; human western blot; human	Klemmt P, Liu F, Carver J, Jones C, Brosi D, Adamson J, et al. Effects of gonadotrophin releasing hormone analogues on human endometrial stromal cells and embryo invasion in vitro. Hum Reprod. 2009;24:2187-92 pubmed publisher
immunohistochemistry; human western blot; human	Angelucci C, Lama G, Iacopino F, Ferracuti S, Bono A, Millar R, et al. GnRH receptor expression in human prostate cancer cells is affected by hormones and growth factors. Endocrine. 2009;36:87-97 pubmed publisher
western blot; rat; 1:100	Sengupta A, Chakrabarti N, Sridaran R. Presence of immunoreactive gonadotropin releasing hormone (GnRH) and its receptor (GnRHR) in rat ovary during pregnancy. Mol Reprod Dev. 2008;75:1031-44 pubmed
immunohistochemistry; rat; 1:200 western blot; rat; 1:100	Sengupta A, Sridaran R. Expression and localization of gonadotropin-releasing hormone receptor in the rat oviduct during pregnancy. J Histochem Cytochem. 2008;56:25-31 pubmed
	Doroszko M, Chruściel M, Stelmaszewska J, Ślężak T, Anisimowicz S, Plockinger U, et al. GnRH antagonist treatment of malignant adrenocortical tumors. Endocr Relat Cancer. 2019;26:103-117 pubmed publisher

image

image 1 :

Formalin-fixed, paraffin-embedded human pituitary stained with GnRH-Receptor antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of anterior pituitary cells.

product information

Product Type :

Antibody

Product Name :

GnRHR Monoclonal Antibody (GNRH03)

Catalog # :

MA5-11538

Quantity :

500 µL

Pricing :

US 419

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-dependent, Immunohistochemistry (Paraffin): 1:100

Species :

Human

Clone :

GNRH03

Isotype :

IgG1

Storage :

4° C

Description :

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5 region and multiple polyA signals in the 3 region have been identified for this gene.

Immunogen :

A synthetic peptide aa 1-29 (MAN-SASPEQNQNHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRH receptor

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunohistochemistry (Paraffin): 1:100

Aliases :

GH1; GnRH receptor; Gnrhr; gnRH-R; GNRHR1; gonadotropin releasing hormone receptor; gonadotropin releasing hormone receptor type-I; gonadotropin-releasing hormone (type 1) receptor 1; gonadotropin-releasing hormone receptor; GRHR; growth hormone; HH7; HHG; hypergonadotropic hypogonadism; LCGR; leutinizing hormone releasing horomone receptor; leutinizing-releasing hormone receptor; LGR2; LH/CGR; LH/CG-R; LHCGR; LHR; Lh-rh receptor; Lhrhr; LRHR; LSH-R; luliberin receptor; Luteinizing hormone receptor; luteinizing hormone/choriogonadotropin receptor; lutropin/choriogonadotropin receptor; lutropin-choriogonadotropic hormone receptor; type I GnRH receptor; Type I GNRHR1; ULG5

more info or order :

Invitrogen product webpage