Caspase 3 Monoclonal Antibody (3CSP01 (7.1.44)) | Invitrogen MA5-11516 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Caspase 3 Monoclonal Antibody (3CSP01 (7.1.44))

catalog :

MA5-11516

quantity :

500 µL

price :

US 475

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3CSP01 (7.1.44)

reactivity :

squamates, human, rat, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; domestic rabbit western blot; domestic rabbit	Vose L, Vinukonda G, Jo S, Miry O, Diamond D, Korumilli R, et al. Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage. J Neurosci. 2013;33:17232-46 pubmed publisher
immunohistochemistry; rat; 1:100	Koroglu T, Yilmaz O, Gokmen N, Tugyan K, Baskin H, Egrilmez M. Erythropoietin prevents lymphoid apoptosis but has no effect on survival in experimental sepsis. Pediatr Res. 2013;74:148-53 pubmed publisher
immunohistochemistry; rat; 1:400	Ding Z, Burghoff S, Buchheiser A, Kogler G, Schrader J. Survival, integration, and differentiation of unrestricted somatic stem cells in the heart. Cell Transplant. 2013;22:15-27 pubmed publisher
immunohistochemistry; rat	Qiao L, Xie L, Shi K, Zhou T, Hua Y, Liu H. Notch signaling change in pulmonary vascular remodeling in rats with pulmonary hypertension and its implication for therapeutic intervention. PLoS ONE. 2012;7:e51514 pubmed publisher
western blot; human; 1:100	Zheng J, Hu J, Chen Y, Chen B, Huang Y, Zheng Z, et al. Baicalin induces apoptosis in leukemia HL-60/ADR cells via possible down-regulation of the PI3K/Akt signaling pathway. Asian Pac J Cancer Prev. 2012;13:1119-24 pubmed
immunocytochemistry; human; 1:300	Rzayev Z, Turk M, Söylemez E. Bioengineering functional copolymers. XXI. Synthesis of a novel end carboxyl-trithiocarbonate functionalized poly(maleic anhydride) and its interaction with cancer cells. Bioorg Med Chem. 2012;20:5053-61 pubmed publisher
immunohistochemistry; rat; 1:100	Baykara B, Micili S, Tugyan K, Tekmen I, Bagriyanik H, Sonmez U, et al. The protective effects of carnosine in alcohol-induced hepatic injury in rats. Toxicol Ind Health. 2014;30:25-32 pubmed publisher
immunohistochemistry; human; 1:50	Fan C, Lin X, Wang E. Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study. Tumour Biol. 2012;33:1045-52 pubmed
immunohistochemistry; rat; 1:100	Fouad A, Jresat I. Captopril and telmisartan treatments attenuate cadmium-induced testicular toxicity in rats. Fundam Clin Pharmacol. 2013;27:152-60 pubmed publisher
immunocytochemistry; human immunohistochemistry; human; 1:50	Markovic O, Marisavljevic D, Cemerikic V, Perunicic M, Savic S, Filipovic B, et al. Clinical and prognostic significance of apoptotic profile in patients with newly diagnosed nodal diffuse large B-cell lymphoma (DLBCL). Eur J Haematol. 2011;86:246-55 pubmed publisher
immunocytochemistry; human; 1:300	Turk M, Rzayev Z, Khalilova S. Bioengineering functional copolymers. XIV. Synthesis and interaction of poly(N-isopropylacrylamide-co-3,4-dihydro-2H-pyran-alt-maleic anhydride)s with SCLC cancer cells. Bioorg Med Chem. 2010;18:7975-84 pubmed publisher
immunohistochemistry; squamates; 1:100	Ferrandino I, Favorito R, Annunziata M, Grimaldi M. Cadmium induces apoptosis in the pituitary gland of Podarcis sicula. Ann N Y Acad Sci. 2009;1163:386-8 pubmed publisher
	Chen Q, Ma K, Liu X, Chen S, Li P, Yu Y, et al. Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis. Cell Discov. 2022;8:3 pubmed publisher
	Mir Coll J, Moede T, Paschen M, Neelakandhan A, Valladolid Acebes I, Leibiger B, et al. Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes. Int J Mol Sci. 2021;22: pubmed publisher
	Olorundare O, Adeneye A, Akinsola A, Ajayi A, Agede O, Soyemi S, et al. Therapeutic Potentials of Selected Antihypertensive Agents and Their Fixed-Dose Combinations Against Trastuzumab-Mediated Cardiotoxicity. Front Pharmacol. 2020;11:610331 pubmed publisher
	Sharif M, Whitehouse A, Sharman P, Perry M, Adams M. Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3. Arthritis Rheum. 2004;50:507-15 pubmed

image

image 1 :

Formalin-fixed, paraffin-embedded human tonsil stained with Caspase 3 antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic and nuclear staining of lymphoid cells.

product information

Product Type :

Antibody

Product Name :

Caspase 3 Monoclonal Antibody (3CSP01 (7.1.44))

Catalog # :

MA5-11516

Quantity :

500 µL

Pricing :

US 475

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:50-1:100, Immunoprecipitation: 1:25-1:50, Western Blot: 1:25-1:50

Species :

Human

Clone :

3CSP01 (7.1.44)

Isotype :

IgG2a

Storage :

4° C

Description :

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Immunogen :

Recombinant full length human Caspase 3 protein

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:100, Immunoprecipitation: 1:25-1:50, Western Blot: 1:25-1:50

Aliases :

A830040C14Rik; AC-3; Apopain; Apopain precursor; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase3; caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; Caspase-3-like protein; CC3; Cpp32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; cysteine protease; CPP32; apopain; ICE3; IRP; LICE; mldy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein

more info or order :

Invitrogen product webpage