E-cadherin Monoclonal Antibody (DH01 (DCS-266)) | Invitrogen MA5-11496 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

E-cadherin Monoclonal Antibody (DH01 (DCS-266))

catalog :

MA5-11496

quantity :

500 µL

price :

US 449.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DH01 (DCS-266)

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 15

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 5d	Matsuura K, Huang N, Cocce K, Zhang L, Kornbluth S. Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin. Oncogene. 2017;36:1698-1706 pubmed publisher
western blot; human; 1:500; fig s2	Feringa F, Krenning L, Koch A, van den Berg J, van den Broek B, Jalink K, et al. Hypersensitivity to DNA damage in antephase as a safeguard for genome stability. Nat Commun. 2016;7:12618 pubmed publisher
western blot; human	Voets E, Wolthuis R. MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C. Biol Open. 2015;4:484-95 pubmed publisher
immunoprecipitation; human; 1:500	Boekhout M, Wolthuis R. Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20. J Cell Sci. 2015;128:1639-53 pubmed publisher
western blot; mouse	Naoe H, Chiyoda T, Ishizawa J, Masuda K, Saya H, Kuninaka S. The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells. Biochem Biophys Res Commun. 2013;430:757-62 pubmed publisher
western blot; human	Burrows A, Prokop J, Summers M. Skp1-Cul1-F-box ubiquitin ligase (SCF(?TrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry. J Biol Chem. 2012;287:39021-9 pubmed publisher
western blot; human	Binné U, Classon M, Dick F, Wei W, Rape M, Kaelin W, et al. Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat Cell Biol. 2007;9:225-32 pubmed
western blot; human; 1:1000	Cheung H, Chun A, Wang Q, Deng W, Hu L, Guan X, et al. Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agents. Cancer Res. 2006;66:4357-67 pubmed
western blot; human	Wiebusch L, Bach M, Uecker R, Hagemeier C. Human cytomegalovirus inactivates the G0/G1-APC/C ubiquitin ligase by Cdh1 dissociation. Cell Cycle. 2005;4:1435-9 pubmed
western blot; human	Huang X, Tran T, Zhang L, Hatcher R, Zhang P. DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint. Proc Natl Acad Sci U S A. 2005;102:1065-70 pubmed
	Yu R, Garcia R. NRAS mutant E132K identified in young-onset sporadic colorectal cancer and the canonical mutants G12D and Q61K affect distinct oncogenic phenotypes. Sci Rep. 2020;10:11028 pubmed publisher
	Dasgupta P, Kulkarni P, Majid S, Shahryari V, Hashimoto Y, Bhat N, et al. MicroRNA-203 Inhibits Long Noncoding RNA HOTAIR and Regulates Tumorigenesis through Epithelial-to-mesenchymal Transition Pathway in Renal Cell Carcinoma. Mol Cancer Ther. 2018;17:1061-1069 pubmed publisher
	Bhat N, Colden M, Dar A, Saini S, Arora P, Shahryari V, et al. MicroRNA-720 Regulates E-cadherin-?E-catenin Complex and Promotes Renal Cell Carcinoma. Mol Cancer Ther. 2017;16:2840-2848 pubmed publisher
	Lafranchi L, de Boer H, de Vries E, Ong S, Sartori A, van Vugt M. APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage. EMBO J. 2014;33:2860-79 pubmed publisher
	Parrillas V, Martínez Muñoz L, Holgado B, Kumar A, Cascio G, Lucas P, et al. Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells. Cell Mol Life Sci. 2013;70:545-58 pubmed publisher

product information

Product Type :

Antibody

Product Name :

E-cadherin Monoclonal Antibody (DH01 (DCS-266))

Catalog # :

MA5-11496

Quantity :

500 µL

Price :

US 449.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 1-2 µg/mL, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1-2 µg/mL

Species :

Human

Clone :

DH01 (DCS-266)

Isotype :

IgG1, kappa

Storage :

4° C

Description :

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.

Immunogen :

Recombinant human cdh1 protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1-2 µg/mL, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1-2 µg/mL

Aliases :

AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin