BCL6 Monoclonal Antibody (BL6.02 (PG-B6p)) | Invitrogen MA5-11493 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

BCL6 Monoclonal Antibody (BL6.02 (PG-B6p))

catalog :

MA5-11493

quantity :

500 µL

price :

US 430

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

BL6.02 (PG-B6p)

reactivity :

human, mouse, rat, bovine, pigs , domestic sheep, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig s2a	Lu H, Wang T, Li J, Fedele C, Liu Q, Zhang J, et al. αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor. Cancer Res. 2016;76:5163-74 pubmed publisher
immunohistochemistry; human; 1:20	Akay O, Aras B, Isiksoy S, Toprak C, Mutlu F, Artan S, et al. BCL2, BCL6, IGH, TP53, and MYC protein expression and gene rearrangements as prognostic markers in diffuse large B-cell lymphoma: a study of 44 Turkish patients. Cancer Genet. 2014;207:87-93 pubmed publisher
immunohistochemistry; human; 1:100	Demirkesen C, Tuzuner N, Esen T, Lebe B, Ozkal S. The expression of IgM is helpful in the differentiation of primary cutaneous diffuse large B cell lymphoma and follicle center lymphoma. Leuk Res. 2011;35:1269-72 pubmed publisher
immunohistochemistry; human	Ferrara G, Chiarelli C, Simonetti S. B-cell lymphofollicular infiltrates in mycosis fungoides. Tumori. 2010;96:487-91 pubmed
immunohistochemistry - paraffin section; human; 1:20; fig 1 immunohistochemistry; human; 1:20	Liu T, Chen S, Kuo S, Cheng A, Lin C. E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response. Mod Pathol. 2010;23:1507-17 pubmed publisher
immunohistochemistry; human	Smit L, Hallaert D, Spijker R, de Goeij B, Jaspers A, Kater A, et al. Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity. Blood. 2007;109:1660-8 pubmed
immunocytochemistry; human	Kukreja A, Hutchinson A, Dhodapkar K, Mazumder A, Vesole D, Angitapalli R, et al. Enhancement of clonogenicity of human multiple myeloma by dendritic cells. J Exp Med. 2006;203:1859-65 pubmed
immunohistochemistry; human	Vaiphei K, Kumari N, Sinha S, Dutta U, Nagi B, Joshi K, et al. Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease. World J Gastroenterol. 2006;12:3602-8 pubmed
	Srivastava S, Makala H, Sharma V, Suri V, Sarkar C, Kulshreshtha R. MED12 is overexpressed in glioblastoma patients and serves as an oncogene by targeting the VDR/BCL6/p53 axis. Cell Mol Life Sci. 2022;79:104 pubmed publisher
	Kurth J, Hansmann M, Rajewsky K, Kuppers R. Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction. Proc Natl Acad Sci U S A. 2003;100:4730-5 pubmed
	Wlodarska I, Nooyen P, Maes B, Martin Subero J, Siebert R, Pauwels P, et al. Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma. Blood. 2003;101:706-10 pubmed

image

image 1 :

Formalin-fixed, paraffin-embedded human tonsil stained with Bcl-6 antibody using peroxidase-conjugate and AEC chromogen. Note nuclear staining of lymphocytes in the germinal center.

product information

Product Type :

Antibody

Product Name :

BCL6 Monoclonal Antibody (BL6.02 (PG-B6p))

Catalog # :

MA5-11493

Quantity :

500 µL

Pricing :

US 430

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Bovine, Human, Mouse, Ovine, Porcine, Rabbit, Rat

Applications :

Immunohistochemistry (Paraffin): 1:20, Western Blot: 1:10-1:100

Species :

Bovine, Human, Mouse, Ovine, Porcine, Rabbit, Rat

Clone :

BL6.02 (PG-B6p)

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.

Immunogen :

Recombinant protein corresponding to amino acids 3-484 of the human Bcl-6 protein

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:20, Western Blot: 1:10-1:100

Aliases :

B cell CLL/lymphoma 6; B cell leukemia/lymphoma 6; B-cell CLL/lymphoma 6; B-cell CLL/lymphoma 6 (zinc finger protein 51); B-cell leukemia/lymphoma 5; B-cell leukemia/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein homolog; B-cell lymphoma 6 protein transcript; BCL5; BCL-5; Bcl6; Bcl-6; BCL6 transcription repressor; BCL6A; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ3; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; protein LAZ-3; ZBTB27; zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S; ZNF51

more info or order :

Invitrogen product webpage