CDK1 Monoclonal Antibody (A17.1.1) | Invitrogen MA5-11472 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CDK1 Monoclonal Antibody (A17.1.1)

catalog :

MA5-11472

quantity :

500 uL

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A17.1.1

reactivity :

guinea pig, human, mouse, rat, chicken, Xenopus laevis

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 22

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; loading ...; fig 3a	Schwermer M, Dreesmann S, Eggert A, Althoff K, Steenpass L, Schramm A, et al. Pharmaceutically inhibiting polo-like kinase 1 exerts a broad anti-tumour activity in retinoblastoma cell lines. Clin Exp Ophthalmol. 2017;45:288-296 pubmed publisher
western blot; rat; fig 2	Zhang Y, Yu J, Lee C, Xu B, Sartor M, Koenig R. Genomic binding and regulation of gene expression by the thyroid carcinoma-associated PAX8-PPARG fusion protein. Oncotarget. 2015;6:40418-32 pubmed publisher
immunoprecipitation; human; fig 1	Jirawatnotai S, Sharma S, Michowski W, Suktitipat B, Geng Y, Quackenbush J, et al. The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis. Cell Cycle. 2014;13:2889-900 pubmed publisher
immunoprecipitation; mouse western blot; mouse; 1:200; fig 3e	Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour M, et al. Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014;16:1080-91 pubmed publisher
immunohistochemistry - paraffin section; human; 1:500	Silva A, Santos A, Farfel J, Grinberg L, Ferretti R, Campos A, et al. Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease. PLoS ONE. 2014;9:e99897 pubmed publisher
immunohistochemistry; human	Cinti C, Vindigni C, Zamparelli A, La Sala D, Epistolato M, Marrelli D, et al. Activated Akt as an indicator of prognosis in gastric cancer. Virchows Arch. 2008;453:449-55 pubmed publisher
western blot; human	Choi J, Murillo G, Su B, Pezzuto J, Kinghorn A, Mehta R. Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells. FEBS J. 2006;273:5714-23 pubmed
immunohistochemistry; human; 1:500	Nakamura N, Yamamoto H, Yao T, Oda Y, Nishiyama K, Imamura M, et al. Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk grade. Hum Pathol. 2005;36:828-37 pubmed
western blot; human; 1:200	Raynaud F, Whittaker S, Fischer P, McClue S, Walton M, Barrie S, et al. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clin Cancer Res. 2005;11:4875-87 pubmed
	Zhao Y, Yang Y, Wu X, Zhang L, Cai X, Ji J, et al. CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification. JCI Insight. 2024;9: pubmed publisher
	Han Z, Jia Q, Zhang J, Chen M, Wang L, Tong K, et al. Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis. J Exp Clin Cancer Res. 2023;42:228 pubmed publisher
	Kawaguchi K, Kohashi K, Iwasaki T, Yamamoto T, Ishihara S, Toda Y, et al. Prognostic value of nuclear morphometry in myxoid liposarcoma. Cancer Sci. 2023;114:2178-2188 pubmed publisher
	Kicuntod J, H xe4 ge S, Hahn F, Sticht H, Marschall M. The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors. Viruses. 2022;14: pubmed publisher
	Caller L, Davies C, Antrobus R, Lehner P, Weekes M, Crump C. Temporal proteomic analysis of BK polyomavirus infection reveals virus-induced G2 arrest and highly effective evasion of innate immune sensing. J Virol. 2019;: pubmed publisher
	Hsieh W, Huang Y, Wang T, Ming Y, Tsai C, Pang J. IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes. Cell Prolif. 2015;48:187-97 pubmed publisher
	Whittaker S, Walton M, Garrett M, Workman P. The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. Cancer Res. 2004;64:262-72 pubmed
	Sheen J, Woo J, Dickson R. c-Myc alters the DNA damage-induced G2/M arrest in human mammary epithelial cells. Br J Cancer. 2003;89:1479-85 pubmed
	Petermann A, Pippin J, Hiromura K, Monkawa T, Durvasula R, Couser W, et al. Mitotic cell cycle proteins increase in podocytes despite lack of proliferation. Kidney Int. 2003;63:113-22 pubmed
	Sandal T, Stapnes C, Kleivdal H, Hedin L, Døskeland S. A novel, extraneuronal role for cyclin-dependent protein kinase 5 (CDK5): modulation of cAMP-induced apoptosis in rat leukemia cells. J Biol Chem. 2002;277:20783-93 pubmed
	Leoncini L, Lazzi S, Scano D, Mura A, Onida A, Massarelli G, et al. Expression of the ALK protein by anaplastic large-cell lymphomas correlates with high proliferative activity. Int J Cancer. 2000;86:777-81 pubmed
	Leoncini L, Bellan C, Cossu A, Claudio P, Lazzi S, Cinti C, et al. Retinoblastoma-related p107 and pRb2/p130 proteins in malignant lymphomas: distinct mechanisms of cell growth control. Clin Cancer Res. 1999;5:4065-72 pubmed
	Leoncini L, Cossu A, Megha T, Bellan C, Lazzi S, Luzi P, et al. Expression of p34(cdc2) and cyclins A and B compared to other proliferative features of non-Hodgkin's lymphomas: a multivariate cluster analysis. Int J Cancer. 1999;83:203-9 pubmed

product information

Product Type :

Antibody

Product Name :

CDK1 Monoclonal Antibody (A17.1.1)

Catalog # :

MA5-11472

Quantity :

500 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Chicken, Guinea Pig, Human, Mouse, Rat, Rodent, Xenopus laevis

Applications :

Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Paraffin): 2-4 ug/mL, Immunoprecipitation: 2 ug/mg protein lysate, Western Blot: 1-2 ug/mL

Species :

Chicken, Guinea Pig, Human, Mouse, Rat, Rodent, Xenopus laevis

Clone :

A17.1.1

Isotype :

IgG2a, kappa

Storage :

4 C

Description :

CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.

Immunogen :

C-Terminal 2/3 of Xenopus CDC2 expressed in E. coli

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Paraffin): 2-4 ug/mL, Immunoprecipitation: 2 ug/mg protein lysate, Western Blot: 1-2 ug/mL

Aliases :

5363; ABL1; cdc; CDC2; cdc-2; cdc2 kinase; CDC28A; Cdc2a; cdc2-a; cdc2Dm; cdc2x1.1; CDCDm; CDK1; Cdk-1; cdk1.S; CDK1/CDC2; CDK1-A; cdk1-b; Cdk1-PA; CDKN1; cell cycle controller CDC2; cell cycle p34 CDC2 kinase protein; cell division control; cell division control protein 2 homolog; Cell division control protein 2 homolog 1; cell division control protein 2-A; cell division cycle 2 homolog A; cell division cycle 2 like; cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division cycle control protein 2a; cell division protein kinase 1; Cell division protein kinase 1-A; CG5363; CG5363-PA; cyclin dependent kinase; cyclin dependent kinase 1; cyclin-dependent kinase; Cyclin-dependent kinase 1; cyclin-dependent kinase 1 S homeolog; cyclin-dependent kinase 1-A; D2366; Dcdc2; dCdk1; DKFZp686L20222; Dm cdc2; Dmcdc2; DmCdk1; Dmel CG5363; Dmel_CG5363; DNA polymerase delta catalytic subunit; DNA polymerase III; DNA-directed DNA polymerase delta POL3; group 4; HPR6; KCIP-1; l(2)31Eh; LD38718p; maturation-promoting factor; MGC111195; MGC53829; MPF; OTTHUMP00000019660; P34 CDK1; P34 MGC111195; p34 protein kinase; p34 protein kinase 1; p34 ; p34cdc2; p34-cdc2 homologue; POL3; Protein 1054; protein 2; PSTAIR; TEX1; unnamed protein product; xcdc2; XELAEV_18036802mg; YDL102W

more info or order :

Invitrogen product webpage